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Clgn Gene Detail
Summary
  • Symbol
    Clgn
  • Name
    calmegin
  • Synonyms
    4930459O04Rik, A2/6, calnexin-t, Cln
  • Feature Type
    protein coding gene
  • IDs
    MGI:107472
    NCBI Gene: 12745
  • Gene Overview
    MyGene.info: CLGN
Location & Maps
more
  • Sequence Map
    Chr8:83389867-83428552 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      38686 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 39.97 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CLGN, calmegin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CLGN, calmegin
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 1047
    neXtProt AC: NX_O14967

  • Chr Location
    4q28.3-q31.1; chr4:140388453-140427661 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 68392
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: CLGN
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Chemically induced (other)
    1
  • Gene trapped
    10
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Clgn
  • Incidental Mutations
Males homozygous for a targeted null mutation exhibit severely impaired fertility associated with an apparent defect in either sperm/zona pellucida binding and/or sperm transit to the oviduct.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022192 VEGA Gene Model | MGI Sequence Detail 38686 C57BL/6J ±  kb
transcript OTTMUST00000052718 VEGA | MGI Sequence Detail 3902 Not Applicable  
polypeptide OTTMUSP00000025033 VEGA | MGI Sequence Detail 611 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    490 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000005573 calmegin
  • InterPro Domains
    IPR001580 Calreticulin/calnexin
    IPR018124 Calreticulin/calnexin, conserved site
    IPR009033 Calreticulin/calnexin, P domain
    IPR013320 Concanavalin A-like lectin/glucanase domain
Molecular
Reagents
less
  • All nucleic 14
    cDNA 12
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-2017, MGD-MRK-36039, MGI:1922128, MGI:2142583
References
more
  • Summaries
    All 50
    Developmental Gene Expression 10
    Gene Ontology 10
    Phenotypes 37
  • Earliest
    J:17254 Watanabe D, et al., Molecular cloning of a novel Ca(2+)-binding protein (calmegin) specifically expressed during male meiotic germ cell development. J Biol Chem. 1994 Mar 11;269(10):7744-9
  • Latest
    J:210341 Fujihara Y, et al., GPI-anchored protein complex, LY6K/TEX101, is required for sperm migration into the oviduct and male fertility in mice. Biol Reprod. 2014 Mar;90(3):60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory