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Clgn
Gene Detail
Symbol

Name
ID
Clgn
calmegin
MGI:107472
Synonyms
4930459O04Rik, A2/6, calnexin-t, Cln
Feature Type
protein coding gene
Genetic Map
Chromosome 8
39.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:83389867-83428552 bp, + strand
From VEGA annotation of GRCm38

  38686 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68392  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: calnexin
Gene Tree: Clgn

Human
homologs
Human Homolog CLGN, calmegin
NCBI Gene ID 1047
neXtProt AC  NX_O14967
Human Chr (Location)  4q28.3-q31.1; chr4:140388453-140427661 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(10) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Males homozygous for a targeted null mutation exhibit severely impaired fertility associated with an apparent defect in either sperm/zona pellucida binding and/or sperm transit to the oviduct.
 
Interactions
Clgn interacts with 219 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process binding of sperm to zona pellucida, cell differentiation, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function calcium ion binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (94)    Tissues (45)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 94
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(12) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000022192 (Evidence)
Ensembl Gene ModelENSMUSG00000002190 (Evidence)
Entrez Gene12745 (Evidence)
DFCITC1645982, TC1584552
DoTSDT.55238179, DT.483454, DT.99851559
NIA Mouse Gene IndexU009552
Consensus CDS ProjectCCDS22452.1
International Mouse Knockout Project StatusClgn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022192 VEGA Gene Model | MGI Sequence Detail 38686 C57BL/6J ±  kb
transcript OTTMUST00000052718 VEGA | MGI Sequence Detail 3902 Not Applicable 
polypeptide OTTMUSP00000025033 VEGA | MGI Sequence Detail 611 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(8) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(518 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001580 Calreticulin/calnexin
InterPro IPR018124 Calreticulin/calnexin, conserved site
InterPro IPR009033 Calreticulin/calnexin, P domain
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
Protein Ontology PR:000005573 calmegin
References
(Earliest) J:17254 Watanabe D, et al., Molecular cloning of a novel Ca(2+)-binding protein (calmegin) specifically expressed during male meiotic germ cell development. J Biol Chem. 1994 Mar 11;269(10):7744-9
(Latest) J:202012 Pandey RR, et al., Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice. Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16492-7
All references(55)
Other
accession IDs
MGD-MRK-2017, MGD-MRK-36039, MGI:1922128, MGI:2142583

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory