Numb
Gene Detail

Symbol Name ID

Numb numb gene homolog (Drosophila) MGI:107423

Synonyms

m-numb

Feature Type

protein coding gene

Genetic Map

Chromosome 12

38.89 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr12:83794034-83921934 bp, - strand From VEGA annotation of GRCm38   127901 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2775  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: numb/numb-like protein
Gene Tree: Numb

Human homologs

Human Homolog		NUMB, numb homolog (Drosophila)
NCBI Gene ID		8650
neXtProt AC		NX_P49757
Human Synonyms		c14_5527, C14orf41, S171
Human Chr (Location)		14q24.3; chr14:73275205-73458582 (-)  GRCh38

Alleles and phenotypes

All alleles(54) : Gene trapped(47) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a null allele die at ~E11.5 with neural tube closure defects and precocious cortical neurogenesis. Mice homozygous for another null allele show impaired axial rotation, neural tube closure, angiogenic remodeling, placenta formation, and motor and sensory neuron differentiation.

 

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	adherens junction organization, axonogenesis, ...
Component	apical part of cell, basolateral plasma membrane, ...
Function	alpha-catenin binding, beta-catenin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (36 records)

Data Summary: Results (117)    Tissues (60)    Images (37)
Theiler Stages: 16, 18, 19, 20, 21, 23, 25, 28

Assay Type	Results
Immunohistochemistry	9
RNA in situ	77
Western blot	31

cDNA source data(79)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(81) Genomic(1) cDNA(79) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000031495 (Evidence)
Ensembl Gene Model	ENSMUSG00000021224 (Evidence)
Entrez Gene	18222 (Evidence)
UniGene	4390
DFCI	TC1576911, TC1603162, TC1604865, TC1659573, TC1750840, TC1771071
DoTS	DT.101389097, DT.60118656, DT.91329925, DT.91380996, DT.94366598, DT.96085500, DT.97376639, DT.97376640
NIA Mouse Gene Index	U034155
PDB	1WJ1
Consensus CDS Project	CCDS26032.1, CCDS49108.1, CCDS70400.1, CCDS70401.1
International Mouse Knockout Project Status	Numb

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031495	VEGA Gene Model | MGI Sequence Detail	127901	C57BL/6J
transcript	OTTMUST00000078072	VEGA | MGI Sequence Detail	1962	Not Applicable
polypeptide	OTTMUSP00000041442	VEGA | MGI Sequence Detail	653	Not Applicable

All sequences(103) RefSeq(24) UniProt(7)

Polymorphisms

SNPs within 2kb(834 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR010449	NUMB domain
InterPro	IPR016698	Numb/numb-like
InterPro	IPR006020	Phosphotyrosine interaction domain
InterPro	IPR011993	Pleckstrin homology-like domain
Protein Ontology	PR:000011504	protein numb

References

(Earliest) J:34328 Zhong W, et al., Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis. Neuron. 1996 Jul;17(1):43-53
(Latest) J:206589 Zhao C, et al., Numb family proteins are essential for cardiac morphogenesis and progenitor differentiation. Development. 2014 Jan;141(2):281-95
All references(83)

Other accession IDs

MGD-MRK-35893