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Numb Gene Detail
Summary
  • Symbol
    Numb
  • Name
    NUMB endocytic adaptor protein
  • Synonyms
    m-numb
  • Feature Type
    protein coding gene
  • IDs
    MGI:107423
    NCBI Gene: 18222
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:83840808-83968708 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 38.89 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    829 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107423
 protein coding gene Chr12:83840808-83968713 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019918
 protein coding gene Chr12:84447792-84586916 (-)
A/J MGP_AJ_G0019875
 protein coding gene Chr12:81251460-81381899 (-)
AKR/J MGP_AKRJ_G0019851
 protein coding gene Chr12:83453105-83586359 (-)
BALB/cJ MGP_BALBcJ_G0019855
 protein coding gene Chr12:81598304-81725943 (-)
C3H/HeJ MGP_C3HHeJ_G0019661
 protein coding gene Chr12:83915228-84046702 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020307
 protein coding gene Chr12:86862699-86999289 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017924
 protein coding gene Chr12:78171262-78305126 (-)
CAST/EiJ MGP_CASTEiJ_G0019210
 protein coding gene Chr12:78846617-78986760 (-)
CBA/J MGP_CBAJ_G0019632
 protein coding gene Chr12:90205689-90340822 (-)
DBA/2J MGP_DBA2J_G0019747
 protein coding gene Chr12:80794991-80925082 (-)
FVB/NJ MGP_FVBNJ_G0019733
 protein coding gene Chr12:79744115-79872854 (-)
LP/J MGP_LPJ_G0019819
 protein coding gene Chr12:84319292-84460846 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019772
 protein coding gene Chr12:93180920-93320297 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020341
 protein coding gene Chr12:83041362-83174401 (-)
PWK/PhJ MGP_PWKPhJ_G0018974
 protein coding gene Chr12:75267813-75404200 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018769
 protein coding gene Chr12:77517644-77666864 (-)
WSB/EiJ MGP_WSBEiJ_G0019262
 protein coding gene Chr12:83713228-83858432 (-)



Homology
more
  • Human Ortholog
    NUMB, NUMB endocytic adaptor protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NUMB, NUMB endocytic adaptor protein
  • Synonyms
    c14_5527, C14orf41, S171
  • Links
    NCBI Gene ID: 8650
    neXtProt AC: NX_P49757
    UniProt: P49757

  • Chr Location
    14q24.2-q24.3; chr14:73275210-73458580 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 4 alleles in 5 genetic backgrounds
    35 phenotypes from multigenic genotypes
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die at ~E11.5 with neural tube closure defects and precocious cortical neurogenesis. Mice homozygous for another null allele show impaired axial rotation, neural tube closure, angiogenic remodeling, placenta formation, and motor and sensory neuron differentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    814
  • Tissues
    72
  • cDNA Data
    80
  • Literature Summary
    60
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021224 Ensembl Gene Model | MGI Sequence Detail 127901 C57BL/6J ±  kb
    transcript ENSMUST00000129335 Ensembl | MGI Sequence Detail 1962 Not Applicable  
    polypeptide ENSMUSP00000119303 Ensembl | MGI Sequence Detail 653 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 82
      Genomic 1
      cDNA 80
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-35893
    References
    more
    • Summaries
      All 141
      Developmental Gene Expression 60
      Gene Ontology 21
      Phenotypes 49
    • Earliest
      J:34328 Zhong W, et al., Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis. Neuron. 1996 Jul;17(1):43-53
    • Latest
      J:322948 Li MR, et al., MAD2B promotes podocyte injury through regulating Numb-dependent Notch 1 pathway in diabetic nephropathy. Int J Biol Sci. 2022;18(5):1896-1911
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/28/2022
    MGI 6.20     		The Jackson Laboratory