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Numb Gene Detail
Summary
  • Symbol
    Numb
  • Name
    NUMB endocytic adaptor protein
  • Synonyms
    m-numb
  • Feature Type
    protein coding gene
  • IDs
    MGI:107423
    NCBI Gene: 18222
  • Gene Overview
    MyGene.info: NUMB
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:83794034-83921934 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 38.89 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    833 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107423
protein coding gene Chr12:83794034-83921934 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019918
protein coding gene Chr12:84447792-84586916 (-)
A/J MGP_AJ_G0019875
protein coding gene Chr12:81251460-81381899 (-)
AKR/J MGP_AKRJ_G0019851
protein coding gene Chr12:83453105-83586359 (-)
BALB/cJ MGP_BALBcJ_G0019855
protein coding gene Chr12:81598304-81725943 (-)
C3H/HeJ MGP_C3HHeJ_G0019661
protein coding gene Chr12:83915228-84046702 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020307
protein coding gene Chr12:86862699-86999289 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017924
protein coding gene Chr12:78171262-78305126 (-)
CAST/EiJ MGP_CASTEiJ_G0019210
protein coding gene Chr12:78846617-78986760 (-)
CBA/J MGP_CBAJ_G0019632
protein coding gene Chr12:90205689-90340822 (-)
DBA/2J MGP_DBA2J_G0019747
protein coding gene Chr12:80794991-80925082 (-)
FVB/NJ MGP_FVBNJ_G0019733
protein coding gene Chr12:79744115-79872854 (-)
LP/J MGP_LPJ_G0019819
protein coding gene Chr12:84319292-84460846 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019772
protein coding gene Chr12:93180920-93320297 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020341
protein coding gene Chr12:83041362-83174401 (-)
PWK/PhJ MGP_PWKPhJ_G0018974
protein coding gene Chr12:75267813-75404200 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018769
protein coding gene Chr12:77517644-77666864 (-)
WSB/EiJ MGP_WSBEiJ_G0019262
protein coding gene Chr12:83713228-83858432 (-)



Homology
more
  • Human Ortholog
    NUMB, NUMB, endocytic adaptor protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NUMB, NUMB, endocytic adaptor protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    c14_5527, C14orf41, S171
  • Links
    NCBI Gene ID: 8650
    neXtProt AC: NX_P49757
    UniProt: P49757

  • Chr Location
    14q24.2-q24.3; chr14:73275210-73458580 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 4 alleles in 5 genetic backgrounds
    35 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die at ~E11.5 with neural tube closure defects and precocious cortical neurogenesis. Mice homozygous for another null allele show impaired axial rotation, neural tube closure, angiogenic remodeling, placenta formation, and motor and sensory neuron differentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18222 NCBI Gene Model | MGI Sequence Detail 127901 C57BL/6J ±  kb
    transcript NR_073564 RefSeq | MGI Sequence Detail 3595 C57BL/6  
    polypeptide Q9QZS3 UniProt | EBI | MGI Sequence Detail 653 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 82
      Genomic 1
      cDNA 80
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-35893
    References
    more
    • Summaries
      All 117
      Developmental Gene Expression 50
      Gene Ontology 18
      Phenotypes 39
    • Earliest
      J:34328 Zhong W, et al., Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis. Neuron. 1996 Jul;17(1):43-53
    • Latest
      J:255488 Premarathne S, et al., Loss of Usp9x disrupts cell adhesion, and components of the Wnt and Notch signaling pathways in neural progenitors. Sci Rep. 2017 Aug 14;7(1):8109

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory