Numb MGI Mouse Gene Detail - MGI:107423 - NUMB endocytic adaptor protein

Symbol

Numb
Name

NUMB endocytic adaptor protein
Synonyms

m-numb

Feature Type

protein coding gene
IDs

MGI:107423
NCBI Gene: 18222
Gene Overview

MyGene.info: NUMB
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr12:83794034-83921934 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 38.89 cM, cytoband D3
Mapping Data

2 experiments

SNPs within 2kb

833 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107423	protein coding gene	Chr12:83794034-83921934 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019918	protein coding gene	Chr12:84447792-84586916 (-)
A/J	MGP_AJ_G0019875	protein coding gene	Chr12:81251460-81381899 (-)
AKR/J	MGP_AKRJ_G0019851	protein coding gene	Chr12:83453105-83586359 (-)
BALB/cJ	MGP_BALBcJ_G0019855	protein coding gene	Chr12:81598304-81725943 (-)
C3H/HeJ	MGP_C3HHeJ_G0019661	protein coding gene	Chr12:83915228-84046702 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020307	protein coding gene	Chr12:86862699-86999289 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017924	protein coding gene	Chr12:78171262-78305126 (-)
CAST/EiJ	MGP_CASTEiJ_G0019210	protein coding gene	Chr12:78846617-78986760 (-)
CBA/J	MGP_CBAJ_G0019632	protein coding gene	Chr12:90205689-90340822 (-)
DBA/2J	MGP_DBA2J_G0019747	protein coding gene	Chr12:80794991-80925082 (-)
FVB/NJ	MGP_FVBNJ_G0019733	protein coding gene	Chr12:79744115-79872854 (-)
LP/J	MGP_LPJ_G0019819	protein coding gene	Chr12:84319292-84460846 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019772	protein coding gene	Chr12:93180920-93320297 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020341	protein coding gene	Chr12:83041362-83174401 (-)
PWK/PhJ	MGP_PWKPhJ_G0018974	protein coding gene	Chr12:75267813-75404200 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018769	protein coding gene	Chr12:77517644-77666864 (-)
WSB/EiJ	MGP_WSBEiJ_G0019262	protein coding gene	Chr12:83713228-83858432 (-)

Human Ortholog

NUMB, NUMB, endocytic adaptor protein

Vertebrate Orthologs

10

Human Ortholog

NUMB, NUMB, endocytic adaptor protein
Orthology source: HomoloGene, HGNC
Synonyms

c14_5527, C14orf41, S171
Links

HGNC:8060

NCBI Gene ID: 8650

neXtProt AC: NX_P49757

UniProt: P49757
Chr Location

14q24.2-q24.3; chr14:73275210-73458580 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 2775
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: NUMB
Protein SuperFamily

numb/numb-like protein
Gene Tree

Numb

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Phenotype Summary

38 phenotypes from 4 alleles in 5 genetic backgrounds
35 phenotypes from multigenic genotypes
39 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

55
Chemically induced (other)

1
Gene trapped

47
Targeted

7
Genomic Mutations

1 involving Numb
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

48 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele die at ~E11.5 with neural tube closure defects and precocious cortical neurogenesis. Mice homozygous for another null allele show impaired axial rotation, neural tube closure, angiogenic remodeling, placenta formation, and motor and sensory neuron differentiation.

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All GO Annotations

43
GO References

18

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

131
Tissues

70
cDNA Data

80
Literature Summary

50

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA NUMB

Xenbase numb

ZFIN numb

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Numb interacts with 381 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

89
RefSeq

26
UniProt

8
CCDS

CCDS26032.1, CCDS49108.1, CCDS70400.1, CCDS70401.1
UniGene

4390

Ensembl

ENSMUSG00000021224 (Evidence)
NCBI Gene

18222

			Length	Strain/Species	Flank
genomic	18222	NCBI Gene Model \| MGI Sequence Detail	127901	C57BL/6J	± kb
transcript	NR_073564	RefSeq \| MGI Sequence Detail	3595	C57BL/6
polypeptide	Q9QZS3	UniProt \| EBI \| MGI Sequence Detail	653	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000011504 protein numb

(term hierarchy)
PDB

1WJ1, 5YQG
InterPro Domains

IPR010449 NUMB domain

IPR016698 Numb/numb-like

IPR011993 PH-like domain superfamily

IPR006020 PTB/PI domain

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All nucleic 82

Genomic 1

cDNA 80

Other 1

Microarray probesets 5

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MGD-MRK-35893

Summaries

All 118

Developmental Gene Expression 50

Gene Ontology 18

Phenotypes 39
Earliest

J:34328 Zhong W, et al., Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis. Neuron. 1996 Jul;17(1):43-53
Latest

J:255488 Premarathne S, et al., Loss of Usp9x disrupts cell adhesion, and components of the Wnt and Notch signaling pathways in neural progenitors. Sci Rep. 2017 Aug 14;7(1):8109

TSS for Numb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr116974	Chr12:83921899-83921912 (-)	28 bp
Tssr116973	Chr12:83921809-83921898 (-)	80 bp
Tssr116971	Chr12:83827618-83827645 (-)	94,302 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/15/2019 MGI 6.13