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Numb
Gene Detail
Symbol

Name
ID
Numb
numb gene homolog (Drosophila)
MGI:107423
Synonyms
m-numb
Feature Type
protein coding gene
Genetic Map
Chromosome 12
38.89 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:83794034-83921934 bp, - strand
From VEGA annotation of GRCm38

  127901 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2775  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NUMB
Protein SuperFamily: numb/numb-like protein
Gene Tree: Numb

Human
homologs
NUMB, numb homolog (Drosophila)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8650
neXtProt AC: NX_P49757

Human Synonyms: c14_5527, C14orf41, S171

Human Chr (Location): 14q24.3; chr14:73275154-73458582 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(54) : Gene trapped(47) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele die at ~E11.5 with neural tube closure defects and precocious cortical neurogenesis. Mice homozygous for another null allele show impaired axial rotation, neural tube closure, angiogenic remodeling, placenta formation, and motor and sensory neuron differentiation.
 
Interactions
Numb interacts with 381 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process adherens junction organization, axonogenesis, ...
Component apical part of cell, basolateral plasma membrane, ...
Function alpha-catenin binding, beta-catenin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (40 records)
Data Summary: Results (120)    Tissues (64)    Images (37)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 12
RNA in situ 77
Western blot 31
cDNA source data(79)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA NUMB ; Xenbase numb ; ZFIN numb    NEW 
Molecular
reagents
All nucleic(81) Genomic(1) cDNA(79) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000031495 (Evidence)
Ensembl Gene Model ENSMUSG00000021224 (Evidence)
Entrez Gene 18222 (Evidence)
UniGene 4390
DFCI TC1604865, TC1603162, TC1576911, TC1771071, TC1750840, TC1659573
DoTS DT.96085500, DT.94366598, DT.91380996, DT.91329925, DT.60118656, DT.101389097, DT.97376639, DT.97376640
NIA Mouse Gene Index U034155
PDB 1WJ1
Consensus CDS Project CCDS26032.1, CCDS49108.1, CCDS70400.1, CCDS70401.1
International Mouse Phenotyping Consortium Status Numb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031495 VEGA Gene Model | MGI Sequence Detail 127901 C57BL/6J ±  kb
transcript OTTMUST00000078072 VEGA | MGI Sequence Detail 1962 Not Applicable 
polypeptide OTTMUSP00000041442 VEGA | MGI Sequence Detail 653 Not Applicable 

For the selected sequences
All sequences(105) RefSeq(26) UniProt(7)
Polymorphisms
SNPs within 2kb(834 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010449 NUMB domain
InterPro IPR016698 Numb/numb-like
InterPro IPR006020 Phosphotyrosine interaction domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000011504 protein numb
References
(Earliest) J:34328 Zhong W, et al., Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis. Neuron. 1996 Jul;17(1):43-53
(Latest) J:218238 Swarnkar G, et al., Osteopetrosis in TAK1-deficient mice owing to defective NF-kappaB and NOTCH signaling. Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):154-9
All references(90)
Other
accession IDs
MGD-MRK-35893

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory