About   Help   FAQ
Numb
Gene Detail
 Symbol
Name
ID
Numb
numb gene homolog (Drosophila)
MGI:107423
Synonyms m-numb
Feature Type protein coding gene
Genetic Map
Chromosome 12
38.89 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:83794034-83921934 bp, - strand
From VEGA annotation of GRCm38

  127901 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2775  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: numb/numb-like protein
Gene Tree: Numb

Human
homologs
Human Homolog NUMB, numb homolog (Drosophila)
NCBI Gene ID 8650
neXtProt AC  NX_P49757
Human Synonyms  c14_5527, C14orf41, S171
Human Chr (Location)  14q24.3; chr14:73275205-73458582 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(54) : Gene trapped(47) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele die at ~E11.5 with neural tube closure defects and precocious cortical neurogenesis. Mice homozygous for another null allele show impaired axial rotation, neural tube closure, angiogenic remodeling, placenta formation, and motor and sensory neuron differentiation.
 
Interactions
Numb interacts with 382 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process adherens junction organization, axonogenesis, ...
Component apical part of cell, basolateral plasma membrane, ...
Function alpha-catenin binding, beta-catenin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (36 records)
Data Summary: Results (117)    Tissues (61)    Images (37)
Theiler Stages: 16, 18, 19, 20, 21, 23, 25, 27, 28
Assay TypeResults
Immunohistochemistry 9
RNA in situ 77
Western blot 31
cDNA source data(79)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(81) Genomic(1) cDNA(79) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000031495 (Evidence)
Ensembl Gene ModelENSMUSG00000021224 (Evidence)
Entrez Gene18222 (Evidence)
UniGene4390
DFCITC1576911, TC1603162, TC1604865, TC1659573, TC1750840, TC1771071
DoTSDT.101389097, DT.60118656, DT.91329925, DT.91380996, DT.94366598, DT.96085500, DT.97376639, DT.97376640
NIA Mouse Gene IndexU034155
PDB1WJ1
Consensus CDS ProjectCCDS26032.1, CCDS49108.1, CCDS70400.1, CCDS70401.1
International Mouse Knockout Project StatusNumb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031495 VEGA Gene Model | MGI Sequence Detail 127901 C57BL/6J ±  kb
transcript OTTMUST00000078072 VEGA | MGI Sequence Detail 1962 Not Applicable 
polypeptide OTTMUSP00000041442 VEGA | MGI Sequence Detail 653 Not Applicable 

For the selected sequences
All sequences(103) RefSeq(24) UniProt(7)
Polymorphisms SNPs within 2kb(834 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010449 NUMB domain
InterPro IPR016698 Numb/numb-like
InterPro IPR006020 Phosphotyrosine interaction domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000011504 protein numb
References (Earliest) J:34328 Zhong W, et al., Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis. Neuron. 1996 Jul;17(1):43-53
(Latest) J:206589 Zhao C, et al., Numb family proteins are essential for cardiac morphogenesis and progenitor differentiation. Development. 2014 Jan;141(2):281-95
All references(84)
Other
accession IDs
MGD-MRK-35893

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory