Numb MGI Mouse Gene Detail - MGI:107423 - NUMB endocytic adaptor protein

Numb Gene Detail

Symbol

Numb
Name

NUMB endocytic adaptor protein
Synonyms

m-numb

Feature Type

protein coding gene
IDs

MGI:107423
NCBI Gene: 18222
Gene Overview

MyGene.info: NUMB
Alliance

gene page

Sequence Map

Chr12:83794034-83921934 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

127901 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 38.89 cM, cytoband D3
Mapping Data

2 experiments

Human Ortholog

NUMB, NUMB, endocytic adaptor protein

Vertebrate Orthologs

10

Human Ortholog

NUMB, NUMB, endocytic adaptor protein
Orthology source: HomoloGene, HGNC
Synonyms

c14_5527, C14orf41, S171
Links

HGNC:8060

NCBI Gene ID: 8650

neXtProt AC: NX_P49757

UniProt: P49757
Chr Location

14q24.2-q24.3; chr14:73275210-73458580 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 2775
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: NUMB
Protein SuperFamily

numb/numb-like protein
Gene Tree

Numb

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Phenotype Summary

38 phenotypes from 4 alleles in 5 genetic backgrounds
35 phenotypes from multigenic genotypes
39 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

55
Chemically induced (other)

1
Gene trapped

47
Targeted

7
Genomic Mutations

1 involving Numb
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

46 strains or lines available

Mice homozygous for a null allele die at ~E11.5 with neural tube closure defects and precocious cortical neurogenesis. Mice homozygous for another null allele show impaired axial rotation, neural tube closure, angiogenic remodeling, placenta formation, and motor and sensory neuron differentiation.

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All GO Annotations

39
GO References

19

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

122
Tissues

66
cDNA Data

79
Literature Summary

49

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA NUMB

Xenbase numb

ZFIN numb

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Numb interacts with 381 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

93
RefSeq

26
UniProt

8
CCDS

CCDS26032.1, CCDS49108.1, CCDS70400.1, CCDS70401.1
UniGene

4390

			Length	Strain/Species	Flank
genomic	OTTMUSG00000031495	VEGA Gene Model \| MGI Sequence Detail	127901	C57BL/6J	± kb
transcript	OTTMUST00000078072	VEGA \| MGI Sequence Detail	1962	Not Applicable
polypeptide	OTTMUSP00000041442	VEGA \| MGI Sequence Detail	653	Not Applicable

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SNPs within 2kb

833 from dbSNP Build 142

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UniProt

8 Sequences
Protein Ontology

PR:000011504 protein numb

(term hierarchy)
PDB

1WJ1, 5YQG
InterPro Domains

IPR010449 NUMB domain

IPR016698 Numb/numb-like

IPR011993 PH-like domain superfamily

IPR006020 PTB/PI domain

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All nucleic 81

Genomic 1

cDNA 79

Other 1

Microarray probesets 5

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MGD-MRK-35893

Summaries

All 116

Developmental Gene Expression 49

Gene Ontology 19

Phenotypes 39
Earliest

J:34328 Zhong W, et al., Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis. Neuron. 1996 Jul;17(1):43-53
Latest

J:255488 Premarathne S, et al., Loss of Usp9x disrupts cell adhesion, and components of the Wnt and Notch signaling pathways in neural progenitors. Sci Rep. 2017 Aug 14;7(1):8109

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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