Ctss MGI Mouse Gene Detail - MGI:107341

Symbol

Ctss
Name

cathepsin S
Synonyms

Cat S

Feature Type

protein coding gene
IDs

MGI:107341
NCBI Gene: 13040
Gene Overview

MyGene.info: CTSS
Alliance

gene page
Transcription Start Sites

20 TSS

Sequence Map

Chr3:95526786-95556403 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 40.74 cM
Mapping Data

6 experiments

SNPs within 2kb

231 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107341	protein coding gene	Chr3:95526786-95556405 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027586	protein coding gene	Chr3:96271948-96309678 (+)
A/J	MGP_AJ_G0027545	protein coding gene	Chr3:93274878-93305432 (+)
AKR/J	MGP_AKRJ_G0027512	protein coding gene	Chr3:95445698-95478498 (+)
BALB/cJ	MGP_BALBcJ_G0027557	protein coding gene	Chr3:93055128-93085279 (+)
C3H/HeJ	MGP_C3HHeJ_G0027290	protein coding gene	Chr3:95734908-95765335 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028005	protein coding gene	Chr3:99827026-99861070 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025345	protein coding gene	Chr3:89597306-89640044 (+)
CAST/EiJ	MGP_CASTEiJ_G0026740	protein coding gene	Chr3:95002876-95035832 (+)
CBA/J	MGP_CBAJ_G0027267	protein coding gene	Chr3:103476728-103506676 (+)
DBA/2J	MGP_DBA2J_G0027406	protein coding gene	Chr3:92562132-92592703 (+)
FVB/NJ	MGP_FVBNJ_G0027377	protein coding gene	Chr3:90641443-90670616 (+)
LP/J	MGP_LPJ_G0027515	protein coding gene	Chr3:97576544-97612193 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027404	protein coding gene	Chr3:109582131-109619561 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028059	protein coding gene	Chr3:95083754-95116602 (+)
PWK/PhJ	MGP_PWKPhJ_G0026468	protein coding gene	Chr3:92447917-92481438 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026289	protein coding gene	Chr3:93371284-93407201 (+)
WSB/EiJ	MGP_WSBEiJ_G0026822	protein coding gene	Chr3:95474848-95508907 (+)

Human Ortholog

CTSS, cathepsin S

Vertebrate Orthologs

11

Human Ortholog

CTSS, cathepsin S
Orthology source: HomoloGene, HGNC
Links

HGNC:2545

NCBI Gene ID: 1520

neXtProt AC: NX_P25774

UniProt: P25774
Chr Location

1q21.3; chr1:150730196-150765957 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 20867
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: CTSS
Gene Tree

Ctss

Diseases

1 with Ctss mouse models

Human Disease

Mouse Models

Duchenne muscular dystrophy

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

2 with disease annotations

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Phenotype Summary

22 phenotypes from 4 alleles in 5 genetic backgrounds
19 phenotypes from multigenic genotypes
46 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (ENU)

1
Chemically induced (other)

1
Gene trapped

7
Radiation induced

1
Targeted

5
Transgenic

1
Genomic Mutations

2 involving Ctss
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice are resistant to the development of experimental autoimmune myasthenia gravis and showed reduced T and B cell responses to acetylcholine receptor.

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All GO Annotations

38
GO References

10

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

53
Tissues

14
cDNA Data

135
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ctss

ZFIN ctss1, ctss2.1, ctss2.2

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Ctss interacts with 34 markers (Mir10b, Mir15b, Mir23b, ...) View All

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All Sequences

54
RefSeq

6
UniProt

7
CCDS

CCDS50992.1, CCDS71291.1
UniGene

3619

Ensembl

ENSMUSG00000038642 (Evidence)
NCBI Gene

13040

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038642	Ensembl Gene Model \| MGI Sequence Detail	29618	C57BL/6J	± kb
transcript	ENSMUST00000015667	Ensembl \| MGI Sequence Detail	1355	Not Applicable
polypeptide	ENSMUSP00000015667	Ensembl \| MGI Sequence Detail	341	Not Applicable

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UniProt

7 Sequences
PDB

1M0H, 4BPV, 4BQV, 4BS5, 4BS6, 4BSQ, 4MZO, 4MZS
EC

3.4.22.27
InterPro Domains

IPR013201 Cathepsin propeptide inhibitor domain (I29)

IPR025661 Cysteine peptidase, asparagine active site

IPR000169 Cysteine peptidase, cysteine active site

IPR025660 Cysteine peptidase, histidine active site

IPR039417 Papain-like cysteine endopeptidase

IPR038765 Papain-like cysteine peptidase superfamily

IPR013128 Peptidase C1A

IPR000668 Peptidase C1A, papain C-terminal

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All nucleic 138

cDNA 135

Primer pair 3

Microarray probesets 3

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MGD-MRK-35807

Summaries

All 109

Developmental Gene Expression 8

Diseases 2

Gene Ontology 10

Phenotypes 46
Earliest

J:47501 Shi GP, et al., Human cathepsin S: chromosomal localization, gene structure, and tissue distribution. J Biol Chem. 1994 Apr 15;269(15):11530-6
Latest

J:264154 Ziegler PK, et al., Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis. Cell. 2018 Jun 28;174(1):88-101.e16

TSS for Ctss:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30563	Chr3:95526777-95526797 (+)	1 bp
Tssr30564	Chr3:95526800-95526811 (+)	20 bp
Tssr30565	Chr3:95526819-95526871 (+)	59 bp
Tssr30566	Chr3:95526878-95526889 (+)	98 bp
Tssr30567	Chr3:95529428-95529536 (+)	2,696 bp
Tssr30580	Chr3:95543009-95543137 (+)	16,287 bp
Tssr30581	Chr3:95545331-95545345 (+)	18,552 bp
Tssr30582	Chr3:95545346-95545352 (+)	18,563 bp
Tssr30583	Chr3:95545354-95545365 (+)	18,574 bp
Tssr30584	Chr3:95545368-95545387 (+)	18,592 bp
Tssr30585	Chr3:95545398-95545430 (+)	18,628 bp
Tssr30586	Chr3:95545459-95545471 (+)	18,679 bp
Tssr30587	Chr3:95545472-95545489 (+)	18,695 bp
Tssr30588	Chr3:95545498-95545513 (+)	18,720 bp
Tssr30589	Chr3:95545521-95545541 (+)	18,745 bp
Tssr30592	Chr3:95550048-95550060 (+)	23,268 bp
Tssr30593	Chr3:95550074-95550086 (+)	23,294 bp
Tssr970	Chr3:95550091-95550097 (+)	23,308 bp
Tssr30594	Chr3:95550101-95550119 (+)	23,324 bp
Tssr30595	Chr3:95550125-95550129 (+)	23,341 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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