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Ctss Gene Detail
Summary
  • Symbol
    Ctss
  • Name
    cathepsin S
  • Synonyms
    Cat S
  • Feature Type
    protein coding gene
  • IDs
    MGI:107341
    NCBI Gene: 13040
  • Gene Overview
    MyGene.info: CTSS
Location & Maps
more
  • Sequence Map
    Chr3:95526786-95556400 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      29615 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 40.74 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    CTSS, cathepsin S
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CTSS, cathepsin S
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 1520
    neXtProt AC: NX_P25774
    UniProt: P25774

  • Chr Location
    1q21.3; chr1:150730196-150765957 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 20867
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CTSS
  • Gene Tree
    Ctss
Human Diseases
more
  • Diseases
    1 with Ctss mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 4 genetic backgrounds
    19 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are resistant to the development of experimental autoimmune myasthenia gravis and showed reduced T and B cell responses to acetylcholine receptor.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    34
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    45
  • Tissues
    8
  • cDNA Data
    134
  • Literature Summary
    5
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022029 VEGA Gene Model | MGI Sequence Detail 29615 C57BL/6J ±  kb
transcript OTTMUST00000052297 VEGA | MGI Sequence Detail 1355 Not Applicable  
polypeptide OTTMUSP00000024772 VEGA | MGI Sequence Detail 341 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    231 from dbSNP Build 142
  • RFLP
    1
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 137
    cDNA 134
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35807
References
more
  • Summaries
    All 90
    Developmental Gene Expression 5
    Diseases 2
    Gene Ontology 9
    Phenotypes 41
  • Earliest
    J:47501 Shi GP, et al., Human cathepsin S: chromosomal localization, gene structure, and tissue distribution. J Biol Chem. 1994 Apr 15;269(15):11530-6
  • Latest
    J:238995 Yan D, et al., STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1alpha Activation. Cell Rep. 2016 Sep 13;16(11):2914-27
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/13/2017
MGI 6.10 		The Jackson Laboratory