Ctss MGI Mouse Gene Detail - MGI:107341

Ctss Gene Detail

Symbol

Ctss
Name

cathepsin S
Synonyms

Cat S

Feature Type

protein coding gene
IDs

MGI:107341
NCBI Gene: 13040
Gene Overview

MyGene.info: CTSS

Sequence Map

Chr3:95526786-95556400 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

29615 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 40.74 cM
Mapping Data

6 experiments

Human Ortholog

CTSS, cathepsin S

Vertebrate Orthologs

11

Human Ortholog

CTSS, cathepsin S
Orthology source: HomoloGene, HGNC
Links

HGNC:2545

NCBI Gene ID: 1520

neXtProt AC: NX_P25774

UniProt: P25774
Chr Location

1q21.3; chr1:150730196-150765957 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 20867
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: CTSS
Gene Tree

Ctss

Diseases

1 with Ctss mouse models

Human Disease

Mouse Models

Duchenne muscular dystrophy

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

2 with disease annotations

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Phenotype Summary

21 phenotypes from 3 alleles in 4 genetic backgrounds
19 phenotypes from multigenic genotypes
41 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Gene trapped

7
Radiation induced

1
Targeted

5
Transgenic

1
Genomic Mutations

2 involving Ctss
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available

Homozygous null mice are resistant to the development of experimental autoimmune myasthenia gravis and showed reduced T and B cell responses to acetylcholine receptor.

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All GO Annotations

34
GO References

9

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

45
Tissues

8
cDNA Data

134
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ctss

ZFIN ctss1, ctss2.1, ctss2.2

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Ctss interacts with 34 markers (Mir10b, Mir15b, Mir23b, ...) View All

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All Sequences

39
RefSeq

6
UniProt

7
CCDS

CCDS50992.1, CCDS71291.1
UniGene

3619

			Length	Strain/Species	Flank
genomic	OTTMUSG00000022029	VEGA Gene Model \| MGI Sequence Detail	29615	C57BL/6J	± kb
transcript	OTTMUST00000052297	VEGA \| MGI Sequence Detail	1355	Not Applicable
polypeptide	OTTMUSP00000024772	VEGA \| MGI Sequence Detail	341	Not Applicable

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SNPs within 2kb

231 from dbSNP Build 142

RFLP

1

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UniProt

7 Sequences
Protein Ontology

PR:000006033 cathepsin S

(term hierarchy)
PDB

1M0H, 4BPV, 4BQV, 4BS5, 4BS6, 4BSQ, 4MZO, 4MZS
EC

3.4.22.27
InterPro Domains

IPR013201 Cathepsin propeptide inhibitor domain (I29)

IPR025661 Cysteine peptidase, asparagine active site

IPR000169 Cysteine peptidase, cysteine active site

IPR025660 Cysteine peptidase, histidine active site

IPR013128 Peptidase C1A

IPR000668 Peptidase C1A, papain C-terminal

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All nucleic 137

cDNA 134

Primer pair 3

Microarray probesets 3

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MGD-MRK-35807

Summaries

All 90

Developmental Gene Expression 5

Diseases 2

Gene Ontology 9

Phenotypes 41
Earliest

J:47501 Shi GP, et al., Human cathepsin S: chromosomal localization, gene structure, and tissue distribution. J Biol Chem. 1994 Apr 15;269(15):11530-6
Latest

J:238995 Yan D, et al., STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1alpha Activation. Cell Rep. 2016 Sep 13;16(11):2914-27

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 07/11/2017 MGI 6.10