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Ctss
Gene Detail
Symbol

Name
ID
Ctss
cathepsin S
MGI:107341
Synonyms
Cat S
Feature Type
protein coding gene
Genetic Map
Chromosome 3
40.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr3:95526786-95556400 bp, + strand
From VEGA annotation of GRCm38

  29615 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20867  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: CTSS
Gene Tree: Ctss

Human
homologs
CTSS, cathepsin S
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1520
neXtProt AC: NX_P25774

Human Chr (Location): 1q21; chr1:150730196-150765957 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(7) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are resistant to the development of experimental autoimmune myasthenia gravis and showed reduced T and B cell responses to acetylcholine receptor.
 
Interactions
Ctss interacts with 34 markers (Mir10b, Mir15b, Mir23b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (45)    Tissues (8)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 21
RT-PCR 17
cDNA source data(134)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ctss ; ZFIN ctssa, ctssb.1, ctssb.2    NEW 
Molecular
reagents
All nucleic(137) cDNA(134) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000022029 (Evidence)
Ensembl Gene Model ENSMUSG00000038642 (Evidence)
Entrez Gene 13040 (Evidence)
UniGene 3619
DFCI TC1574527
DoTS DT.97367723, DT.111053799
NIA Mouse Gene Index U003571
EC 3.4.22.27
PDB 1M0H, 4MZO, 4BSQ, 4BQV, 4BPV, 4MZS, 4BS5, 4BS6
Consensus CDS Project CCDS50992.1, CCDS71291.1
International Mouse Phenotyping Consortium Status Ctss
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022029 VEGA Gene Model | MGI Sequence Detail 29615 C57BL/6J ±  kb
transcript OTTMUST00000052297 VEGA | MGI Sequence Detail 1355 Not Applicable 
polypeptide OTTMUSP00000024772 VEGA | MGI Sequence Detail 341 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(6) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(236 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025661 Cysteine peptidase, asparagine active site
InterPro IPR000169 Cysteine peptidase, cysteine active site
InterPro IPR025660 Cysteine peptidase, histidine active site
InterPro IPR013128 Peptidase C1A, papain
InterPro IPR000668 Peptidase C1A, papain C-terminal
InterPro IPR013201 Proteinase inhibitor I29, cathepsin propeptide
Protein Ontology PR:000006033 cathepsin S
References
(Earliest) J:47501 Shi GP, et al., Human cathepsin S: chromosomal localization, gene structure, and tissue distribution. J Biol Chem. 1994 Apr 15;269(15):11530-6
(Latest) J:220057 Shi HT, et al., Cathepsin S contributes to macrophage migration via degradation of elastic fibre integrity to facilitate vein graft neointimal hyperplasia. Cardiovasc Res. 2014 Mar 1;101(3):454-63
All references(81)
Other
accession IDs
MGD-MRK-35807

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory