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Ctss Gene Detail
Summary
  • Symbol
    Ctss
  • Name
    cathepsin S
  • Synonyms
    Cat S
  • Feature Type
    protein coding gene
  • IDs
    MGI:107341
    NCBI Gene: 13040
  • Alliance
    genome feature page
  • Transcription Start Sites
    38 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:95434097-95463714 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 40.74 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    965 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107341
 protein coding gene Chr3:95434097-95463716 (+)
129S1/SvImJ ENSMUSG00200041497
 protein coding gene Chr3:92090358-92119846 (+)
A/J ENSMUSG00195042285
 protein coding gene Chr3:92416953-92446570 (+)
AKR/J ENSMUSG00220038975
 protein coding gene Chr3:90804008-90833631 (+)
BALB/cJ ENSMUSG00180039260
 protein coding gene Chr3:92416206-92445898 (+)
C3H/HeJ ENSMUSG00175025544
 protein coding gene Chr3:92060632-92090245 (+)
C57BL/6NJ ENSMUSG00215029966
 protein coding gene Chr3:92779459-92809067 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025345
 protein coding gene Chr3:89597306-89640044 (+)
CAST/EiJ ENSTCUG00005041763
 protein coding gene Chr3:92610864-92641142 (+)
CBA/J ENSMUSG00210050857
 protein coding gene Chr3:92598097-92627705 (+)
DBA/2J ENSMUSG00185041789
 protein coding gene Chr3:93014725-93044308 (+)
FVB/NJ ENSMUSG00205033812
 protein coding gene Chr3:91711359-91740975 (+)
JF1/MsJ ENSUMUG00000045078
 protein coding gene Chr3:91904221-91934493 (+)
LP/J ENSMUSG00230042027
 protein coding gene Chr3:94953797-94983287 (+)
NOD/ShiLtJ ENSMUSG00190045096
 protein coding gene Chr3:93111512-93141031 (+)
NZO/HlLtJ ENSMUSG00225012225
 protein coding gene Chr3:97378175-97407791 (+)
PWK/PhJ ENSLUMG00010049885
 protein coding gene Chr3:91884523-91914498 (+)
SPRET/EiJ ENSMSPG00010044974
 protein coding gene Chr3:92187583-92217717 (+)
WSB/EiJ ENSIUOG00005027088
 protein coding gene Chr3:92530886-92561065 (+)



Homology
more
  • Human Ortholog
    CTSS, cathepsin S
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTSS, cathepsin S
  • Links
    NCBI Gene ID: 1520
    UniProt: P25774

  • Chr Location
    1q21.3; chr1:150730079-150765957 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ctss mouse models; 3 with human CTSS associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 5 alleles in 6 genetic backgrounds
    19 phenotypes from multigenic genotypes
    72 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are resistant to the development of experimental autoimmune myasthenia gravis and showed reduced T and B cell responses to acetylcholine receptor.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    655
  • Tissues
    18
  • cDNA Data
    135
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038642 Ensembl Gene Model | MGI Sequence Detail 29618 C57BL/6J ±  kb
    transcript ENSMUST00000015667 Ensembl | MGI Sequence Detail 1355 Not Applicable  
    polypeptide ENSMUSP00000015667 Ensembl | MGI Sequence Detail 341 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 138
      cDNA 135
      Primer pair 3
      Antibodies 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35807
    References
    more
    • Summaries
      All 152
      Developmental Gene Expression 12
      Diseases 2
      Gene Ontology 15
      Phenotypes 72
    • Earliest
      J:47501 Shi GP, et al., Human cathepsin S: chromosomal localization, gene structure, and tissue distribution. J Biol Chem. 1994 Apr 15;269(15):11530-6
    • Latest
      J:387312 Pandey SP, et al., Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity. Immunity. 2025 Oct 14;58(10):2439-2455.e8
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory