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Ctss Gene Detail
Summary
  • Symbol
    Ctss
  • Name
    cathepsin S
  • Synonyms
    Cat S
  • Feature Type
    protein coding gene
  • IDs
    MGI:107341
    NCBI Gene: 13040
  • Gene Overview
    MyGene.info: CTSS
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:95526786-95556403 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 40.74 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    231 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107341
 protein coding gene Chr3:95526786-95556405 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027586
 protein coding gene Chr3:96271948-96309678 (+)
A/J MGP_AJ_G0027545
 protein coding gene Chr3:93274878-93305432 (+)
AKR/J MGP_AKRJ_G0027512
 protein coding gene Chr3:95445698-95478498 (+)
BALB/cJ MGP_BALBcJ_G0027557
 protein coding gene Chr3:93055128-93085279 (+)
C3H/HeJ MGP_C3HHeJ_G0027290
 protein coding gene Chr3:95734908-95765335 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028005
 protein coding gene Chr3:99827026-99861070 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025345
 protein coding gene Chr3:89597306-89640044 (+)
CAST/EiJ MGP_CASTEiJ_G0026740
 protein coding gene Chr3:95002876-95035832 (+)
CBA/J MGP_CBAJ_G0027267
 protein coding gene Chr3:103476728-103506676 (+)
DBA/2J MGP_DBA2J_G0027406
 protein coding gene Chr3:92562132-92592703 (+)
FVB/NJ MGP_FVBNJ_G0027377
 protein coding gene Chr3:90641443-90670616 (+)
LP/J MGP_LPJ_G0027515
 protein coding gene Chr3:97576544-97612193 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027404
 protein coding gene Chr3:109582131-109619561 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028059
 protein coding gene Chr3:95083754-95116602 (+)
PWK/PhJ MGP_PWKPhJ_G0026468
 protein coding gene Chr3:92447917-92481438 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026289
 protein coding gene Chr3:93371284-93407201 (+)
WSB/EiJ MGP_WSBEiJ_G0026822
 protein coding gene Chr3:95474848-95508907 (+)



Homology
more
  • Human Ortholog
    CTSS, cathepsin S
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CTSS, cathepsin S
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 1520
    neXtProt AC: NX_P25774
    UniProt: P25774

  • Chr Location
    1q21.3; chr1:150730196-150765957 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 20867
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CTSS
  • Gene Tree
    Ctss
Human Diseases
more
  • Diseases
    1 with Ctss mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 4 alleles in 5 genetic backgrounds
    19 phenotypes from multigenic genotypes
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice are resistant to the development of experimental autoimmune myasthenia gravis and showed reduced T and B cell responses to acetylcholine receptor.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    685
  • Tissues
    15
  • cDNA Data
    135
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038642 Ensembl Gene Model | MGI Sequence Detail 29618 C57BL/6J ±  kb
    transcript ENSMUST00000015667 Ensembl | MGI Sequence Detail 1355 Not Applicable  
    polypeptide ENSMUSP00000015667 Ensembl | MGI Sequence Detail 341 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 138
      cDNA 135
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35807
    References
    more
    • Summaries
      All 125
      Developmental Gene Expression 9
      Diseases 2
      Gene Ontology 10
      Phenotypes 57
    • Earliest
      J:47501 Shi GP, et al., Human cathepsin S: chromosomal localization, gene structure, and tissue distribution. J Biol Chem. 1994 Apr 15;269(15):11530-6
    • Latest
      J:301351 Flynn CM, et al., Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro. Sci Rep. 2020 Dec 10;10(1):21612
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/06/2021
    MGI 6.16     		The Jackson Laboratory