Ctss
Gene Detail

Symbol

Name
ID

Ctss
cathepsin S
MGI:107341

Synonyms

Cat S

Feature Type

protein coding gene

Genetic Map

Chromosome 3
40.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr3:95526786-95556400 bp, + strand From VEGA annotation of GRCm38   29615 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:20867  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Ctss

Human
homologs

Human Homolog		CTSS, cathepsin S
NCBI Gene ID		1520
neXtProt AC		NX_P25774
Human Chr (Location)		1q21; chr1:150730196-150765957 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(12) : Gene trapped(7) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous null mice are resistant to the development of experimental autoimmune myasthenia gravis and showed reduced T and B cell responses to acetylcholine receptor.

 

Interactions

Ctss interacts with 34 markers (Mir10b, Mir15b, Mir23b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (23 annotations)

Process	basement membrane disassembly, bone resorption, ...
Component	cell surface, extracellular space, ...
Function	collagen binding, cysteine-type endopeptidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)

Data Summary: Results (45)    Tissues (8)    Images (21)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	7
RNA in situ	21
RT-PCR	17

cDNA source data(134)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(137) cDNA(134) Primer pair(3)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000022029 (Evidence)
Ensembl Gene Model	ENSMUSG00000038642 (Evidence)
Entrez Gene	13040 (Evidence)
UniGene	3619
DFCI	TC1574527
DoTS	DT.97367723, DT.111053799
NIA Mouse Gene Index	U003571
EC	3.4.22.27
PDB	4BPV, 1M0H, 4BQV, 4MZS, 4MZO, 4BSQ, 4BS5, 4BS6
Consensus CDS Project	CCDS50992.1, CCDS71291.1
International Mouse Knockout Project Status	Ctss

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022029	VEGA Gene Model | MGI Sequence Detail	29615	C57BL/6J
transcript	OTTMUST00000052297	VEGA | MGI Sequence Detail	1355	Not Applicable
polypeptide	OTTMUSP00000024772	VEGA | MGI Sequence Detail	341	Not Applicable

All sequences(43) RefSeq(6) UniProt(7)

Polymorphisms

RFLP(1) : SNPs within 2kb(236 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR025661	Cysteine peptidase, asparagine active site
InterPro	IPR000169	Cysteine peptidase, cysteine active site
InterPro	IPR025660	Cysteine peptidase, histidine active site
InterPro	IPR013128	Peptidase C1A, papain
InterPro	IPR000668	Peptidase C1A, papain C-terminal
InterPro	IPR013201	Proteinase inhibitor I29, cathepsin propeptide
Protein Ontology	PR:000006033	cathepsin S

References

(Earliest) J:47501 Shi GP, et al., Human cathepsin S: chromosomal localization, gene structure, and tissue distribution. J Biol Chem. 1994 Apr 15;269(15):11530-6
(Latest) J:214746 Lafarge JC, et al., Cathepsin S inhibition lowers blood glucose levels in mice. Diabetologia. 2014 Aug;57(8):1674-83
All references(79)

Other
accession IDs

MGD-MRK-35807