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Cct5 Gene Detail
Summary
  • Symbol
    Cct5
  • Name
    chaperonin containing Tcp1, subunit 5 (epsilon)
  • Synonyms
    Ccte, mKIAA0098, TCPE
  • Feature Type
    protein coding gene
  • IDs
    MGI:107185
    NCBI Gene: 12465
  • Gene Overview
    MyGene.info: CCT5
Location & Maps
more
  • Sequence Map
    Chr15:31590800-31601847 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11048 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 13.02 cM, cytoband B3.2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CCT5, chaperonin containing TCP1 subunit 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CCT5, chaperonin containing TCP1 subunit 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CCTE, CCT-epsilon, HEL-S-69, PNAS-102, TCP-1-epsilon
  • Links
    NCBI Gene ID: 22948
    neXtProt AC: NX_P48643

  • Chr Location
    5p15.2; chr5:10250170-10266389 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 6287
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: CCT5
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human CCT5 associations

Human Disease Mouse Models
       Neuropathy, Hereditary Sensory, with Spastic Paraplegia, Autosomal Recessive   OMIM: 256840
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    2
  • Gene trapped
    6
  • Targeted
    1
  • Genomic Mutations
    2 involving Cct5
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030800 VEGA Gene Model | MGI Sequence Detail 11048 C57BL/6J ±  kb
transcript OTTMUST00000076216 VEGA | MGI Sequence Detail 1896 Not Applicable  
polypeptide OTTMUSP00000040095 VEGA | MGI Sequence Detail 541 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    102 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000005153 T-complex protein 1 subunit epsilon
  • InterPro Domains
    IPR017998 Chaperone tailless complex polypeptide 1 (TCP-1)
    IPR002423 Chaperonin Cpn60/TCP-1 family
    IPR002194 Chaperonin TCP-1, conserved site
    IPR027409 GroEL-like apical domain
    IPR027413 GroEL-like equatorial domain
    IPR012718 T-complex protein 1, epsilon subunit
    IPR027410 TCP-1-like chaperonin intermediate domain
Molecular
Reagents
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  • All nucleic 461
    cDNA 461

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-35646
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 11
    Phenotypes 11
  • Earliest
    J:25228 Kubota H, et al., Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin. Curr Biol. 1994 Feb 1;4(2):89-99
  • Latest
    J:205312 Tarkar A, et al., DYX1C1 is required for axonemal dynein assembly and ciliary motility. Nat Genet. 2013 Sep;45(9):995-1003

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory