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Hmx3
Gene Detail
Symbol

Name
ID
Hmx3
H6 homeobox 3
MGI:107160
Synonyms
Nkx5-1, Nkx5.1
Feature Type
protein coding gene
Genetic Map
Chromosome 7
74.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr7:131542867-131544925 bp, + strand
From VEGA annotation of GRCm38

  2059 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40612  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HMX3
Gene Tree: Hmx3

Human
homologs
HMX3, H6 family homeobox 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 340784
neXtProt AC: NX_A6NHT5

Human Synonyms: Nkx5-1, NKX-5.1, NKX5.1

Human Chr (Location): 10q26.13; chr10:123136051-123137731 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit hyperactivity and circling behavior, and severe vestibular defects. Mutant females are infertile due to failure of implantation.
 
Interactions
Hmx3 interacts with 40 markers (Mir7-1, Mir7-2, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process brain development, cell differentiation, ...
Component nucleus
Function DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (52 records)
Data Summary: Results (258)    Tissues (201)    Images (84)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 228
In situ reporter (knock in) 26
RNase protection 4
cDNA source data(10)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase hmx3 ; ZFIN hmx3a    NEW 
Molecular
reagents
All nucleic(24) Genomic(7) cDNA(12) Primer pair(1) Other(4)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000037286 (Evidence)
Ensembl Gene Model ENSMUSG00000040148 (Evidence)
Entrez Gene 15373 (Evidence)
UniGene 323562
DFCI TC1599408, TC1590168
DoTS DT.97394936, DT.94333998
Consensus CDS Project CCDS21917.1
International Mouse Phenotyping Consortium Status Hmx3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037286 VEGA Gene Model | MGI Sequence Detail 2059 C57BL/6J ±  kb
transcript OTTMUST00000096191 VEGA | MGI Sequence Detail 1457 Not Applicable 
polypeptide OTTMUSP00000053714 VEGA | MGI Sequence Detail 356 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(8) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(9 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008648 homeobox protein HMX3
References
(Earliest) J:17126 Bober E, et al., A novel NK-related mouse homeobox gene: expression in central and peripheral nervous structures during embryonic development. Dev Biol. 1994 Mar;162(1):288-303
(Latest) J:215487 Thompson CL, et al., A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
All references(82)
Other
accession IDs
MGD-MRK-12895, MGD-MRK-35621

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory