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Sin3a Gene Detail
Summary
  • Symbol
    Sin3a
  • Name
    transcriptional regulator, SIN3A (yeast)
  • Synonyms
    mSin3A, Sin3
  • Feature Type
    protein coding gene
  • IDs
    MGI:107157
    NCBI Gene: 20466
  • Gene Overview
    MyGene.info: SIN3A
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:57072040-57128366 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 30.89 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    123 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107157
protein coding gene Chr9:57071991-57128368 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034858
protein coding gene Chr9:56241514-56297422 (+)
A/J MGP_AJ_G0034839
protein coding gene Chr9:54428658-54485400 (+)
AKR/J MGP_AKRJ_G0034768
protein coding gene Chr9:55684512-55742473 (+)
BALB/cJ MGP_BALBcJ_G0034831
protein coding gene Chr9:54231106-54287444 (+)
C3H/HeJ MGP_C3HHeJ_G0034541
protein coding gene Chr9:56157580-56216073 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035350
protein coding gene Chr9:57827879-57886157 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032261
protein coding gene Chr9:53766203-53824586 (+)
CAST/EiJ MGP_CASTEiJ_G0033862
protein coding gene Chr9:56243976-56297834 (+)
CBA/J MGP_CBAJ_G0034512
protein coding gene Chr9:59841046-59906052 (+)
DBA/2J MGP_DBA2J_G0034671
protein coding gene Chr9:54309881-54367015 (+)
FVB/NJ MGP_FVBNJ_G0034613
protein coding gene Chr9:53532137-53589192 (+)
LP/J MGP_LPJ_G0034754
protein coding gene Chr9:56532503-56591030 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034656
protein coding gene Chr9:61317356-61376533 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035372
protein coding gene Chr9:55697969-55758411 (+)
PWK/PhJ MGP_PWKPhJ_G0033567
protein coding gene Chr9:54340449-54396237 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033401
protein coding gene Chr9:55995972-56051191 (+)
WSB/EiJ MGP_WSBEiJ_G0033975
protein coding gene Chr9:55637726-55695861 (+)



Homology
more
  • Human Ortholog
    SIN3A, SIN3 transcription regulator family member A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SIN3A, SIN3 transcription regulator family member A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    WITKOS
  • Links
    NCBI Gene ID: 25942
    neXtProt AC: NX_Q96ST3
    UniProt: Q96ST3

  • Chr Location
    15q24.2; chr15:75369379-75455819 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human SIN3A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Targeted disruption of this gene results in early embryonic lethality. Homozygous null MEFs display poor cell proliferation, reduced S-phase and increased G2/M fractions, a block in DNA replication, and enhanced apoptosis; however, no increase in chromosomal instability is observed.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042557 Ensembl Gene Model | MGI Sequence Detail 56327 C57BL/6J ±  kb
transcript ENSMUST00000168177 Ensembl | MGI Sequence Detail 5086 Not Applicable  
polypeptide ENSMUSP00000130221 Ensembl | MGI Sequence Detail 1277 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 165
    cDNA 162
    Primer pair 2
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-24169, MGD-MRK-35618, MGI:2143326
References
more
  • Summaries
    All 122
    Developmental Gene Expression 16
    Gene Ontology 47
    Phenotypes 17
  • Earliest
    J:28926 Halleck MS, et al., A widely distributed putative mammalian transcriptional regulator containing multiple paired amphipathic helices, with similarity to yeast SIN3. Genomics. 1995 Mar 20;26(2):403-6
  • Latest
    J:252277 Langlet F, et al., Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling. Cell. 2017 Nov 02;171(4):824-835.e18

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory