Targeted disruption of this gene results in early embryonic lethality. Homozygous null MEFs display poor cell proliferation, reduced S-phase and increased G2/M fractions, a block in DNA replication, and enhanced apoptosis; however, no increase in chromosomal instability is observed.
|VEGA Gene Model||OTTMUSG00000036738 (Evidence)|
|Ensembl Gene Model||ENSMUSG00000042557 (Evidence)|
|Entrez Gene||20466 (Evidence)|
|DFCI||TC1576405, TC1584598, TC1601425|
|NIA Mouse Gene Index||U010537|
|PDB||1G1E, 1S5Q, 1S5R, 2L9S, 2LD7, 2RMR, 2RMS|
|Consensus CDS Project||CCDS23216.1, CCDS52805.1|
|International Mouse Phenotyping Consortium Status||Sin3a|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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