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Sin3a
Gene Detail
Symbol

Name
ID
Sin3a
transcriptional regulator, SIN3A (yeast)
MGI:107157
Synonyms
mSin3A, Sin3
Feature Type
protein coding gene
Genetic Map
Chromosome 9
30.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:57072040-57128366 bp, + strand
From VEGA annotation of GRCm38

  56327 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32124  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Sin3a

Human
homologs
Human Homolog SIN3A, SIN3 transcription regulator family member A
NCBI Gene ID 25942
neXtProt AC  NX_Q96ST3
Human Chr (Location)  15q24.2; chr15:75369379-75455815 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(55) : Gene trapped(50) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted disruption of this gene results in early embryonic lethality. Homozygous null MEFs display poor cell proliferation, reduced S-phase and increased G2/M fractions, a block in DNA replication, and enhanced apoptosis; however, no increase in chromosomal instability is observed.
 
Interactions
Sin3a interacts with 238 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (77 annotations)
Process activation of innate immune response, aging, ...
Component chromatin, cytoplasm, ...
Function chromatin binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (83)    Tissues (80)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 74
RT-PCR 7
RNase protection 2
cDNA source data(160)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(164) cDNA(161) Primer pair(2) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000036738 (Evidence)
Ensembl Gene ModelENSMUSG00000042557 (Evidence)
Entrez Gene20466 (Evidence)
UniGene15755
DFCITC1576405, TC1584598, TC1601425
NIA Mouse Gene IndexU010537
PDB1G1E, 1S5Q, 1S5R, 2L9S, 2RMR, 2RMS, 2LD7
Consensus CDS ProjectCCDS23216.1, CCDS52805.1
International Mouse Knockout Project StatusSin3a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036738 VEGA Gene Model | MGI Sequence Detail 56327 C57BL/6J ±  kb
transcript OTTMUST00000094224 VEGA | MGI Sequence Detail 5086 Not Applicable 
polypeptide OTTMUSP00000052360 VEGA | MGI Sequence Detail 1277 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(14) UniProt(4)
Polymorphisms
SNPs within 2kb(123 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013194 Histone deacetylase interacting
InterPro IPR003822 Paired amphipathic helix
Protein Ontology PR:000014877 paired amphipathic helix protein Sin3a
References
(Earliest) J:28926 Halleck MS, et al., A widely distributed putative mammalian transcriptional regulator containing multiple paired amphipathic helices, with similarity to yeast SIN3. Genomics. 1995 Mar 20;26(2):403-6
(Latest) J:202604 Nagamachi A, et al., Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Cancer Cell. 2013 Sep 9;24(3):305-17
All references(91)
Other
accession IDs
MGD-MRK-24169, MGD-MRK-35618, MGI:2143326

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory