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Sin3a Gene Detail
Summary
  • Symbol
    Sin3a
  • Name
    transcriptional regulator, SIN3A (yeast)
  • Synonyms
    mSin3A, Sin3
  • Feature Type
    protein coding gene
  • IDs
    MGI:107157
    NCBI Gene: 20466
  • Gene Overview
    MyGene.info: SIN3A
Location & Maps
more
  • Sequence Map
    Chr9:57072040-57128366 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      56327 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 30.89 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SIN3A, SIN3 transcription regulator family member A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SIN3A, SIN3 transcription regulator family member A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    WITKOS
  • Links
    NCBI Gene ID: 25942
    neXtProt AC: NX_Q96ST3

  • Chr Location
    15q24.2; chr15:75369379-75455815 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SIN3A associations

Human Disease Mouse Models
       Witteveen-Kolk Syndrome; WITKOS   OMIM: 613406
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    55
  • Gene trapped
    50
  • Targeted
    5
  • Incidental Mutations
Targeted disruption of this gene results in early embryonic lethality. Homozygous null MEFs display poor cell proliferation, reduced S-phase and increased G2/M fractions, a block in DNA replication, and enhanced apoptosis; however, no increase in chromosomal instability is observed.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036738 VEGA Gene Model | MGI Sequence Detail 56327 C57BL/6J ±  kb
transcript OTTMUST00000094224 VEGA | MGI Sequence Detail 5086 Not Applicable  
polypeptide OTTMUSP00000052360 VEGA | MGI Sequence Detail 1277 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    123 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 164
    cDNA 161
    Primer pair 2
    Other 1

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-24169, MGD-MRK-35618, MGI:2143326
References
more
  • Summaries
    All 96
    Developmental Gene Expression 14
    Gene Ontology 39
    Phenotypes 15
  • Earliest
    J:28926 Halleck MS, et al., A widely distributed putative mammalian transcriptional regulator containing multiple paired amphipathic helices, with similarity to yeast SIN3. Genomics. 1995 Mar 20;26(2):403-6
  • Latest
    J:233096 Childress P, et al., Genome-Wide Mapping and Interrogation of the Nmp4 Antianabolic Bone Axis. Mol Endocrinol. 2015 Sep;29(9):1269-85

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory