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Sin3a
Gene Detail
Symbol

Name
ID
Sin3a
transcriptional regulator, SIN3A (yeast)
MGI:107157
Synonyms
mSin3A, Sin3
Feature Type
protein coding gene
Genetic Map
Chromosome 9
30.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:57072040-57128366 bp, + strand
From VEGA annotation of GRCm38

  56327 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32124  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: SIN3A
Gene Tree: Sin3a

Human
homologs
SIN3A, SIN3 transcription regulator family member A
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 25942
neXtProt AC: NX_Q96ST3

Human Chr (Location): 15q24.2; chr15:75369379-75455815 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(55) : Gene trapped(50) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted disruption of this gene results in early embryonic lethality. Homozygous null MEFs display poor cell proliferation, reduced S-phase and increased G2/M fractions, a block in DNA replication, and enhanced apoptosis; however, no increase in chromosomal instability is observed.
 
Interactions
Sin3a interacts with 237 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (81 annotations)
Process activation of innate immune response, aging, ...
Component chromatin, cytoplasm, ...
Function chromatin binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (83)    Tissues (80)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 74
RT-PCR 7
RNase protection 2
cDNA source data(160)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA SIN3A ; Xenbase sin3a    NEW 
Molecular
reagents
All nucleic(164) cDNA(161) Primer pair(2) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000036738 (Evidence)
Ensembl Gene Model ENSMUSG00000042557 (Evidence)
Entrez Gene 20466 (Evidence)
UniGene 15755
DFCI TC1576405, TC1584598, TC1601425
NIA Mouse Gene Index U010537
PDB 2RMS, 1G1E, 1S5Q, 2RMR, 2L9S, 1S5R, 2LD7
Consensus CDS Project CCDS23216.1, CCDS52805.1
International Mouse Phenotyping Consortium Status Sin3a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036738 VEGA Gene Model | MGI Sequence Detail 56327 C57BL/6J ±  kb
transcript OTTMUST00000094224 VEGA | MGI Sequence Detail 5086 Not Applicable 
polypeptide OTTMUSP00000052360 VEGA | MGI Sequence Detail 1277 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(22) UniProt(4)
Polymorphisms
SNPs within 2kb(123 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013194 Histone deacetylase interacting
InterPro IPR003822 Paired amphipathic helix
Protein Ontology PR:000014877 paired amphipathic helix protein Sin3a
References
(Earliest) J:28926 Halleck MS, et al., A widely distributed putative mammalian transcriptional regulator containing multiple paired amphipathic helices, with similarity to yeast SIN3. Genomics. 1995 Mar 20;26(2):403-6
(Latest) J:218801 Solaimani P, et al., SIN3A, generally regarded as a transcriptional repressor, is required for induction of gene transcription by the aryl hydrocarbon receptor. J Biol Chem. 2014 Nov 28;289(48):33655-62
All references(92)
Other
accession IDs
MGD-MRK-24169, MGD-MRK-35618, MGI:2143326

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory