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Aff3
Gene Detail
Symbol

Name
ID
Aff3
AF4/FMR2 family, member 3
MGI:106927
Synonyms
3222402O04Rik, Laf4, LAF-4
Feature Type
protein coding gene
Genetic Map
Chromosome 1
16.58 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:38177326-38664955 bp, - strand
From VEGA annotation of GRCm38

  487630 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1718  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: AFF3
Gene Tree: Aff3

Human
homologs
AFF3, AF4/FMR2 family, member 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3899
neXtProt AC: NX_P51826

Human Synonyms: LAF4, MLLT2-like

Human Chr (Location): 2q11.2-q12; chr2:99545864-100142583 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(3) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Aff3 interacts with 282 markers (Mir7-1, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process embryonic hindlimb morphogenesis, regulation of transcription, DNA-templated, ...
Component cytoplasm, nucleoplasm, ...
Function DNA binding, double-stranded DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (235)    Tissues (212)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 220
Northern blot 15
cDNA source data(71)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase aff3 ; ZFIN aff3    NEW 
Molecular
reagents
All nucleic(74) cDNA(72) Primer pair(1) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000019698 (Evidence)
Ensembl Gene Model ENSMUSG00000037138 (Evidence)
Entrez Gene 16764 (Evidence)
UniGene 336679
DFCI TC1695288, TC1678796, TC1611241, TC1585465, TC1604020
DoTS DT.87039962, DT.55122602, DT.40174367, DT.490970
NIA Mouse Gene Index U021256
Consensus CDS Project CCDS48243.1, CCDS69884.1
International Mouse Phenotyping Consortium Status Aff3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019698 VEGA Gene Model | MGI Sequence Detail 487630 C57BL/6J ±  kb
transcript OTTMUST00000047164 VEGA | MGI Sequence Detail 5857 Not Applicable 
polypeptide OTTMUSP00000021301 VEGA | MGI Sequence Detail 1229 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(15) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(4328 from dbSNP Build 137)    SNPs within 2kb including multiple locations(4330)
Protein-related
information
ResourceIDDescription
InterPro IPR007797 Transcription factor AF4/FMR2
Protein Ontology PR:000003805 AF4/FMR2 family member 3
References
(Earliest) J:30625 Ma C, et al., LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias. Blood. 1996 Jan 15;87(2):734-45
(Latest) J:219240 Moore JM, et al., Laf4/Aff3, a gene involved in intellectual disability, is required for cellular migration in the mouse cerebral cortex. PLoS One. 2014;9(8):e105933
All references(43)
Other
accession IDs
MGD-MRK-35388, MGI:1918018

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory