Aff3
Gene Detail

Symbol Name ID

Aff3 AF4/FMR2 family, member 3 MGI:106927

Synonyms

3222402O04Rik, Laf4, LAF-4

Feature Type

protein coding gene

Genetic Map

Chromosome 1

16.58 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:38177326-38664955 bp, - strand From VEGA annotation of GRCm38   487630 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1718  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Aff3

Human homologs

Human Homolog		AFF3, AF4/FMR2 family, member 3
NCBI Gene ID		3899
neXtProt AC		NX_P51826
Human Synonyms		LAF4, MLLT2-like
Human Chr (Location)		2q11.2-q12; chr2:100163715-100759037 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(3) Gene trapped(3)

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	embryonic hindlimb morphogenesis, regulation of transcription, DNA-dependent, ...
Component	nucleolus, nucleus
Function	DNA binding, double-stranded DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (235)    Tissues (212)    Images (35)
Theiler Stages: 17, 19, 21, 22, 23, 28

Assay Type	Results
RNA in situ	220
Northern blot	15

cDNA source data(73)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(76) cDNA(74) Primer pair(1) Other(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000019698 (Evidence)
Ensembl Gene Model	ENSMUSG00000037138 (Evidence)
Entrez Gene	16764 (Evidence)
UniGene	336679
DFCI	TC1585465, TC1604020, TC1611241, TC1678796, TC1695288
DoTS	DT.40174367, DT.490970, DT.55122602, DT.87039962
NIA Mouse Gene Index	U021256
Consensus CDS Project	CCDS48243.1
International Mouse Knockout Project Status	Aff3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000019698	VEGA Gene Model | MGI Sequence Detail	487630	C57BL/6J
transcript	OTTMUST00000047164	VEGA | MGI Sequence Detail	5857	Not Applicable
polypeptide	OTTMUSP00000021301	VEGA | MGI Sequence Detail	1229	Not Applicable

All sequences(50) RefSeq(2) UniProt(7)

Polymorphisms

RFLP(1) : SNPs(3850 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007797	Transcription factor AF4/FMR2
Protein Ontology	PR:000003805	AF4/FMR2 family member 3

References

(Earliest) J:30625 Ma C, et al., LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias. Blood. 1996 Jan 15;87(2):734-45
(Latest) J:175761 Gyurjan I, et al., Analysis of the dynamics of limb transcriptomes during mouse development. BMC Dev Biol. 2011;11:47
All references(41)

Other accession IDs

MGD-MRK-35388, MGI:1918018