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Aff3
Gene Detail
 Symbol
Name
ID
Aff3
AF4/FMR2 family, member 3
MGI:106927
Synonyms 3222402O04Rik, Laf4, LAF-4
Feature Type protein coding gene
Genetic Map
Chromosome 1
16.58 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:38177326-38664955 bp, - strand
From VEGA annotation of GRCm38

  487630 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1718  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Aff3

Human
homologs
Human Homolog AFF3, AF4/FMR2 family, member 3
NCBI Gene ID 3899
neXtProt AC  NX_P51826
Human Synonyms  LAF4, MLLT2-like
Human Chr (Location)  2q11.2-q12; chr2:99545864-100142575 (-)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Targeted(3) Gene trapped(3)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process embryonic hindlimb morphogenesis, regulation of transcription, DNA-templated, ...
Component nucleus
Function DNA binding, double-stranded DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (235)    Tissues (212)    Images (35)
Theiler Stages: 17, 19, 21, 22, 23, 28
Assay TypeResults
RNA in situ 220
Northern blot 15
cDNA source data(71)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(74) cDNA(72) Primer pair(1) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000019698 (Evidence)
Ensembl Gene ModelENSMUSG00000037138 (Evidence)
Entrez Gene16764 (Evidence)
UniGene336679
DFCITC1585465, TC1604020, TC1611241, TC1678796, TC1695288
DoTSDT.40174367, DT.490970, DT.55122602, DT.87039962
NIA Mouse Gene IndexU021256
Consensus CDS ProjectCCDS48243.1
International Mouse Knockout Project StatusAff3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019698 VEGA Gene Model | MGI Sequence Detail 487630 C57BL/6J ±  kb
transcript OTTMUST00000047164 VEGA | MGI Sequence Detail 5857 Not Applicable 
polypeptide OTTMUSP00000021301 VEGA | MGI Sequence Detail 1229 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(10) UniProt(7)
Polymorphisms RFLP(1) : SNPs within 2kb(4328 from dbSNP Build 137)    SNPs within 2kb including multiple locations(4330)
Protein-related
information
ResourceIDDescription
InterPro IPR007797 Transcription factor AF4/FMR2
Protein Ontology PR:000003805 AF4/FMR2 family member 3
References (Earliest) J:30625 Ma C, et al., LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias. Blood. 1996 Jan 15;87(2):734-45
(Latest) J:175761 Gyurjan I, et al., Analysis of the dynamics of limb transcriptomes during mouse development. BMC Dev Biol. 2011;11:47
All references(41)
Other
accession IDs
MGD-MRK-35388, MGI:1918018

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory