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Zic3
Gene Detail
Symbol

Name
ID
Zic3
zinc finger protein of the cerebellum 3
MGI:106676
Synonyms
Ka
Feature Type
protein coding gene
Genetic Map
Chromosome X
32.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(35)
Sequence Map
ChrX:58022700-58041736 bp, + strand
From VEGA annotation of GRCm38

  19037 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55742  Vertebrate Homology Class
1 human; 1 mouse; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ZIC3
Gene Tree: Zic3

Human
homologs
ZIC3, Zic family member 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7547
neXtProt AC: NX_O60481

Human Synonyms: HTX, HTX1, VACTERLX, ZNF203

Human Chr (Location): Xq26.2; chrX:137566187-137572100 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human ZIC3

Mutations,
alleles, and
phenotypes
All mutations/alleles(43) : Gene trapped(33) Spontaneous(2) Targeted(8)
Incidental mutations (data from APF )
 
Mutants show incomplete penetrance varying by genetic background and allele. Phenotypes range from bent tail/skeletal abnormalities to severe defects in embryo turning, cardiac development and neural tube closure resulting in death at embryonic day 18.5
 
Human Diseases Modeled in Mice Using Zic3 (2)    Mutations Annotated to Human Diseases (3)   
Interactions
Zic3 interacts with 356 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process anterior/posterior pattern specification, cell differentiation, ...
Component cytoplasm, nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (38 records)
Data Summary: Results (382)    Tissues (267)    Images (59)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 309
In situ reporter (knock in) 1
Northern blot 1
RT-PCR 47
RNase protection 24
cDNA source data(27)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase zic3 ; ZFIN zic3    NEW 
Molecular
reagents
All nucleic(36) Genomic(2) cDNA(28) Primer pair(5) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000017528 (Evidence)
Ensembl Gene Model ENSMUSG00000067860 (Evidence)
Entrez Gene 22773 (Evidence)
UniGene 255890
DFCI TC1582638, TC1588896, TC1633550
DoTS DT.55163466, DT.50316029, DT.101344050, DT.99841158
NIA Mouse Gene Index U043760
Consensus CDS Project CCDS30155.1
International Mouse Phenotyping Consortium Status Zic3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017528 VEGA Gene Model | MGI Sequence Detail 19037 C57BL/6J ±  kb
transcript OTTMUST00000042579 VEGA | MGI Sequence Detail 3949 Not Applicable 
polypeptide OTTMUSP00000019133 VEGA | MGI Sequence Detail 466 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(12) UniProt(5)
Polymorphisms
PCR(1) : SNPs within 2kb(53 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017667 zinc finger protein ZIC 3
References
(Earliest) J:13124 Garber ED, 'Bent-Tail,' A Dominant, Sex-Linked Mutation in the Mouse. Proc Natl Acad Sci U S A. 1952 Oct;38(10):876-9
(Latest) J:214999 Pearton DJ, et al., Elf5 counteracts precocious trophoblast differentiation by maintaining Sox2 and 3 and inhibiting Hand1 expression. Dev Biol. 2014 Aug 15;392(2):344-57
All references(99)
Disease annotation references (7)
Other
accession IDs
MGD-MRK-1607, MGD-MRK-35135, MGI:3043027, MGI:88185

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory