Zic3
Gene Detail

Symbol Name ID

Zic3 zinc finger protein of the cerebellum 3 MGI:106676

Feature Type

protein coding gene

Genetic Map

Chromosome X

32.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(34)

Sequence Map

ChrX:58022700-58041736 bp, + strand From VEGA annotation of GRCm38   19037 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55742  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Zic3

Human homologs

Human Homolog		ZIC3, Zic family member 3
NCBI Gene ID		7547
neXtProt AC		NX_O60481
Human Synonyms		HTX, HTX1, VACTERLX, ZNF203
Human Chr (Location)		Xq26.2; chrX:136648346-136654259 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human ZIC3

Alleles and phenotypes

All alleles(42) : Targeted(8) Gene trapped(33) Spontaneous(1)
 

Mutants show incomplete penetrance varying by genetic background and allele. Phenotypes range from bent tail/skeletal abnormalities to severe defects in embryo turning, cardiac development and neural tube closure resulting in death at embryonic day 18.5

 
Human Diseases Modeled Using Mouse Zic3 (2)    Alleles Annotated to Human Diseases(3)   

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	anterior/posterior pattern specification, cell differentiation, ...
Component	cytoplasm, nucleus
Function	DNA binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (32 records)
Data Summary: Results (372)    Tissues (254)    Images (55)
Theiler Stages: 2, 3, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	299
In situ reporter (knock in)	1
Northern blot	1
RT-PCR	47
RNase protection	24

cDNA source data(27)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(35) Genomic(2) cDNA(28) Primer pair(4) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000017528 (Evidence)
Ensembl Gene Model	ENSMUSG00000067860 (Evidence)
Entrez Gene	22773 (Evidence)
UniGene	255890
DFCI	TC1582638, TC1588896, TC1633550
DoTS	DT.101344050, DT.50316029, DT.55163466, DT.99841158
NIA Mouse Gene Index	U043760
Consensus CDS Project	CCDS30155.1
International Mouse Knockout Project Status	Zic3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017528	VEGA Gene Model | MGI Sequence Detail	19037	C57BL/6J
transcript	OTTMUST00000042579	VEGA | MGI Sequence Detail	3949	Not Applicable
polypeptide	OTTMUSP00000019133	VEGA | MGI Sequence Detail	466	Not Applicable

All sequences(44) RefSeq(2) UniProt(5)

Polymorphisms

PCR(1) : SNPs(13 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000017667	zinc finger protein ZIC 3

References

(Earliest) J:13124 Garber ED, 'Bent-Tail,' A Dominant, Sex-Linked Mutation in the Mouse. Proc Natl Acad Sci U S A. 1952 Oct;38(10):876-9
(Latest) J:194989 Sutherland MJ, et al., Zic3 is required in the migrating primitive streak for node morphogenesis and left-right patterning. Hum Mol Genet. 2013 May 15;22(10):1913-23
All references(95)

Other accession IDs

MGD-MRK-1607, MGD-MRK-35135, MGI:88185