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Zic3 Gene Detail
Summary
  • Symbol
    Zic3
  • Name
    zinc finger protein of the cerebellum 3
  • Synonyms
    Ka
  • Feature Type
    protein coding gene
  • IDs
    MGI:106676
    NCBI Gene: 22773
  • Gene Overview
    MyGene.info: ZIC3
Location & Maps
more
  • Sequence Map
    ChrX:58022700-58041736 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19037 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 32.56 cM
  • Mapping Data
    35 experiments
Homology
more
  • Human Ortholog
    ZIC3, Zic family member 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ZIC3, Zic family member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HTX, HTX1, VACTERLX, ZNF203
  • Links
    NCBI Gene ID: 7547
    neXtProt AC: NX_O60481

  • Chr Location
    Xq26.2; chrX:137566187-137572100 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Zic3 mouse models; 2 with human ZIC3 associations

Human Disease Mouse Models
       Heterotaxy, Visceral, 1, X-Linked; HTX1   OMIM: 306955 View 6 models
       Hemifacial Microsomia; HFM   OMIM: 164210 View 2 models
       Vacterl Association, X-Linked, with or without Hydrocephalus; VACTERLX   OMIM: 314390
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    111 phenotypes from 6 alleles in 18 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    43
  • Gene trapped
    33
  • Spontaneous
    2
  • Targeted
    8
  • Genomic Mutations
    1 involving Zic3
  • Incidental Mutations
    APF
Mutants show incomplete penetrance varying by genetic background and allele. Phenotypes range from bent tail/skeletal abnormalities to severe defects in embryo turning, cardiac development and neural tube closure resulting in death at embryonic day 18.5
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017528 VEGA Gene Model | MGI Sequence Detail 19037 C57BL/6J ±  kb
transcript OTTMUST00000042579 VEGA | MGI Sequence Detail 3949 Not Applicable  
polypeptide OTTMUSP00000019133 VEGA | MGI Sequence Detail 466 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    973 from dbSNP Build 142
  • PCR
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000017667 zinc finger protein ZIC 3
  • InterPro Domains
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 36
    Genomic 2
    cDNA 28
    Primer pair 5
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-1607, MGD-MRK-35135, MGI:3043027, MGI:88185
References
more
  • Summaries
    All 99
    Developmental Gene Expression 41
    Diseases 7
    Gene Ontology 10
    Phenotypes 28
  • Earliest
    J:13124 Garber ED, 'Bent-Tail,' A Dominant, Sex-Linked Mutation in the Mouse. Proc Natl Acad Sci U S A. 1952 Oct;38(10):876-9
  • Latest
    J:231595 Gurdziel K, et al., Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Dev Dyn. 2016 May;245(5):614-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory