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Zic3 Gene Detail
Summary
  • Symbol
    Zic3
  • Name
    zinc finger protein of the cerebellum 3
  • Synonyms
    Ka
  • Feature Type
    protein coding gene
  • IDs
    MGI:106676
    NCBI Gene: 22773
  • Gene Overview
    MyGene.info: ZIC3
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:58022700-58041736 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 32.56 cM
  • Mapping Data
    35 experiments
Strain
Comparison
more
  • SNPs within 2kb
    973 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106676
protein coding gene ChrX:58021464-58041736 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035751
protein coding gene ChrX:53367807-53386827 (+)
A/J MGP_AJ_G0035734
protein coding gene ChrX:53579561-53599863 (+)
AKR/J MGP_AKRJ_G0035654
protein coding gene ChrX:54976971-54995703 (+)
BALB/cJ MGP_BALBcJ_G0035721
protein coding gene ChrX:52981172-53000982 (+)
C3H/HeJ MGP_C3HHeJ_G0035423
protein coding gene ChrX:53908027-53928158 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036250
protein coding gene ChrX:54769776-54790505 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033101
protein coding gene ChrX:52912426-52931336 (+)
CAST/EiJ MGP_CASTEiJ_G0034716
protein coding gene ChrX:39759065-39831087 (+)
CBA/J MGP_CBAJ_G0035398
protein coding gene ChrX:56402712-56421746 (+)
DBA/2J MGP_DBA2J_G0035552
protein coding gene ChrX:53121403-53140309 (+)
FVB/NJ MGP_FVBNJ_G0035502
protein coding gene ChrX:52726008-52744992 (+)
LP/J MGP_LPJ_G0035640
protein coding gene ChrX:53935651-53954794 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035538
protein coding gene ChrX:57908110-57936951 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036266
protein coding gene ChrX:53379842-53399403 (+)
PWK/PhJ MGP_PWKPhJ_G0034411
protein coding gene ChrX:37977504-37996511 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034256
protein coding gene ChrX:40519554-40591860 (+)
WSB/EiJ MGP_WSBEiJ_G0034859
protein coding gene ChrX:52910151-52929160 (+)



Homology
more
  • Human Ortholog
    ZIC3, Zic family member 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ZIC3, Zic family member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HTX, HTX1, VACTERLX, ZNF203
  • Links
    NCBI Gene ID: 7547
    neXtProt AC: NX_O60481
    UniProt: O60481

  • Chr Location
    Xq26.3; chrX:137566187-137577691 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Zic3 mouse models; 1 with human ZIC3 associations

Human Disease Mouse Models
      
IDs
View 6 models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    112 phenotypes from 6 alleles in 18 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutants show incomplete penetrance varying by genetic background and allele. Phenotypes range from bent tail/skeletal abnormalities to severe defects in embryo turning, cardiac development and neural tube closure resulting in death at embryonic day 18.5
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000067860 Ensembl Gene Model | MGI Sequence Detail 19037 C57BL/6J ±  kb
    transcript ENSMUST00000088627 Ensembl | MGI Sequence Detail 3949 Not Applicable  
    polypeptide ENSMUSP00000085999 Ensembl | MGI Sequence Detail 466 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      Genomic 2
      cDNA 30
      Primer pair 5
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1607, MGD-MRK-35135, MGI:3043027, MGI:88185
    References
    more
    • Summaries
      All 106
      Developmental Gene Expression 44
      Diseases 7
      Gene Ontology 12
      Phenotypes 29
    • Earliest
      J:13124 Garber ED, 'Bent-Tail,' A Dominant, Sex-Linked Mutation in the Mouse. Proc Natl Acad Sci U S A. 1952 Oct;38(10):876-9
    • Latest
      J:256767 Sone M, et al., Hybrid Cellular Metabolism Coordinated by Zic3 and Esrrb Synergistically Enhances Induction of Naive Pluripotency. Cell Metab. 2017 May 2;25(5):1103-1117.e6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory