Dvl2
Gene Detail

Symbol Name ID

Dvl2 dishevelled 2, dsh homolog (Drosophila) MGI:106613

Feature Type

protein coding gene

Genetic Map

Chromosome 11

42.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr11:70000595-70012301 bp, + strand From VEGA annotation of GRCm38   11707 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20927  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: segment polarity protein dishevelled homolog DVL
Gene Tree: Dvl2

Human homologs

Human Homolog		DVL2, dishevelled, dsh homolog 2 (Drosophila)
NCBI Gene ID		1856
neXtProt AC		NX_O14641
Human Chr (Location)		17p13.1; chr17:7128661-7137863 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(11) : Targeted(3) Gene trapped(8)
 

Homozygous mice show incomplete penetrance of perinatal lethality with surviving mice being predominantly female. Defects include cardiovascular outflow and neural tube abnormalities, malformations of vertebrae and ribs, and irregular somite segmentation.

 
Human Diseases Modeled Using Mouse Dvl2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (70 annotations)

Process	canonical Wnt receptor signaling pathway, canonical Wnt receptor signaling pathway involved in regulation of cell proliferation, ...
Component	apical part of cell, cell cortex, ...
Function	frizzled binding, identical protein binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (28 records)
Data Summary: Results (198)    Tissues (141)    Images (29)
Theiler Stages: 1, 2, 3, 4, 5, 17, 19, 20, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	5
RNA in situ	129
RT-PCR	64

cDNA source data(81)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(89) Genomic(2) cDNA(82) Primer pair(5)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000006016 (Evidence)
Ensembl Gene Model	ENSMUSG00000020888 (Evidence)
Entrez Gene	13543 (Evidence)
UniGene	5114
DFCI	TC1574779
DoTS	DT.110532258, DT.492472, DT.94273101
NIA Mouse Gene Index	U108773
PDB	3ML6
Consensus CDS Project	CCDS24930.1
International Mouse Knockout Project Status	Dvl2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006016	VEGA Gene Model | MGI Sequence Detail	11707	C57BL/6J
transcript	OTTMUST00000013481	VEGA | MGI Sequence Detail	2968	Not Applicable
polypeptide	OTTMUSP00000006246	VEGA | MGI Sequence Detail	736	Not Applicable

All sequences(43) RefSeq(2) UniProt(3)

Polymorphisms

All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs(46 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000591	DEP domain
InterPro	IPR008341	Dishevelled-2
InterPro	IPR024580	Dishevelled C-terminal
InterPro	IPR008339	Dishevelled family
InterPro	IPR003351	Dishevelled protein domain
InterPro	IPR015506	Dishevelled-related protein
InterPro	IPR001158	DIX domain
InterPro	IPR001478	PDZ domain
InterPro	IPR011991	Winged helix-turn-helix DNA-binding domain
Protein Ontology	PR:000006767	segment polarity protein dishevelled DVL-2

References

(Earliest) J:33550 Greco TL, et al., Dishevelled-2 maps to human chromosome 17 and distal to Wnt3a and vestigial tail (vt) on mouse chromosome 11. Mamm Genome. 1996 Jun;7(6):475-6
(Latest) J:192848 Cajanek L, et al., Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons. Mol Cell Biol. 2013 Jan;33(1):59-70
All references(91)

Other accession IDs

MGD-MRK-35070