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Dvl2
Gene Detail
 Symbol
Name
ID
Dvl2
dishevelled 2, dsh homolog (Drosophila)
MGI:106613
Feature Type protein coding gene
Genetic Map
Chromosome 11
42.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:70000595-70012301 bp, + strand
From VEGA annotation of GRCm38

  11707 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20927  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: segment polarity protein dishevelled homolog DVL
Gene Tree: Dvl2

Human
homologs
Human Homolog DVL2, dishevelled segment polarity protein 2
NCBI Gene ID 1856
neXtProt AC  NX_O14641
Human Chr (Location)  17p13.1; chr17:7225342-7234548 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(8) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mice show incomplete penetrance of perinatal lethality with surviving mice being predominantly female. Defects include cardiovascular outflow and neural tube abnormalities, malformations of vertebrae and ribs, and irregular somite segmentation.
 
Human Diseases Modeled Using Mouse Dvl2 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Dvl2 interacts with 243 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (69 annotations)
Process canonical Wnt signaling pathway, canonical Wnt signaling pathway involved in regulation of cell proliferation, ...
Component apical part of cell, cell cortex, ...
Function frizzled binding, identical protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (33 records)
Data Summary: Results (194)    Tissues (137)    Images (29)
Theiler Stages: 1, 2, 3, 5, 17, 19, 20, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 5
RNA in situ 129
RT-PCR 60
cDNA source data(82)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(90) Genomic(2) cDNA(83) Primer pair(5)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000006016 (Evidence)
Ensembl Gene ModelENSMUSG00000020888 (Evidence)
Entrez Gene13543 (Evidence)
UniGene5114
DFCITC1574779
DoTSDT.110532258, DT.492472, DT.94273101
NIA Mouse Gene IndexU108773
PDB3ML6
Consensus CDS ProjectCCDS24930.1
International Mouse Knockout Project StatusDvl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006016 VEGA Gene Model | MGI Sequence Detail 11707 C57BL/6J ±  kb
transcript OTTMUST00000013481 VEGA | MGI Sequence Detail 2968 Not Applicable 
polypeptide OTTMUSP00000006246 VEGA | MGI Sequence Detail 736 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(2) UniProt(3)
Polymorphisms All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(90 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000591 DEP domain
InterPro IPR008341 Dishevelled-2
InterPro IPR024580 Dishevelled C-terminal
InterPro IPR008339 Dishevelled family
InterPro IPR003351 Dishevelled protein domain
InterPro IPR015506 Dishevelled-related protein
InterPro IPR001158 DIX domain
InterPro IPR001478 PDZ domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000006767 segment polarity protein dishevelled DVL-2
References (Earliest) J:33550 Greco TL, et al., Dishevelled-2 maps to human chromosome 17 and distal to Wnt3a and vestigial tail (vt) on mouse chromosome 11. Mamm Genome. 1996 Jun;7(6):475-6
(Latest) J:205338 Kuss P, et al., Regulation of cell polarity in the cartilage growth plate and perichondrium of metacarpal elements by HOXD13 and WNT5A. Dev Biol. 2014 Jan 1;385(1):83-93
All references(101)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-35070

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory