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Dvl2 Gene Detail
Summary
  • Symbol
    Dvl2
  • Name
    dishevelled segment polarity protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:106613
    NCBI Gene: 13543
  • Alliance
  • Transcription Start Sites
    5 TSS
  • Candidate for QTL
    8 QTL
Location &
Maps
more
  • Sequence Map
    Chr11:69891418-69900935 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.96 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    73 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106613
protein coding gene Chr11:69891418-69903127 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018577
protein coding gene Chr11:70500178-70511884 (+)
A/J MGP_AJ_G0018545
protein coding gene Chr11:67825532-67837238 (+)
AKR/J MGP_AKRJ_G0018514
protein coding gene Chr11:69846718-69858424 (+)
BALB/cJ MGP_BALBcJ_G0018517
protein coding gene Chr11:68154287-68165992 (+)
C3H/HeJ MGP_C3HHeJ_G0018330
protein coding gene Chr11:69885604-69897310 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018968
protein coding gene Chr11:72617137-72628866 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016613
protein coding gene Chr11:64749832-64761545 (+)
CAST/EiJ MGP_CASTEiJ_G0017885
protein coding gene Chr11:70129476-70141129 (+)
CBA/J MGP_CBAJ_G0018302
protein coding gene Chr11:75876568-75888274 (+)
DBA/2J MGP_DBA2J_G0018412
protein coding gene Chr11:67409870-67421569 (+)
FVB/NJ MGP_FVBNJ_G0018402
protein coding gene Chr11:67057136-67068826 (+)
LP/J MGP_LPJ_G0018482
protein coding gene Chr11:71076072-71088257 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018425
protein coding gene Chr11:76469777-76482440 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019010
protein coding gene Chr11:70121835-70133568 (+)
PWK/PhJ MGP_PWKPhJ_G0017659
protein coding gene Chr11:68062792-68074481 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017449
protein coding gene Chr11:69937285-69948222 (+)
WSB/EiJ MGP_WSBEiJ_G0017939
protein coding gene Chr11:69785849-69797519 (+)



Homology
more
  • Human Ortholog
    DVL2, dishevelled segment polarity protein 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DVL2, dishevelled segment polarity protein 2
  • Links
    NCBI Gene ID: 1856
    neXtProt AC: NX_O14641
    UniProt: O14641

  • Chr Location
    17p13.1; chr17:7225342-7234517 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with Dvl2 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 3 genetic backgrounds
    43 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice show incomplete penetrance of perinatal lethality with surviving mice being predominantly female. Defects include cardiovascular outflow and neural tube abnormalities, malformations of vertebrae and ribs, and irregular somite segmentation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13543 NCBI Gene Model | MGI Sequence Detail 9518 C57BL/6J ±  kb
    transcript NM_007888 RefSeq | MGI Sequence Detail 2969 ZRU/MplStud  
    polypeptide Q60838 UniProt | EBI | MGI Sequence Detail 736 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 101
      Genomic 2
      cDNA 86
      Primer pair 11
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-35070
    References
    more
    • Summaries
      All 161
      Developmental Gene Expression 63
      Diseases 1
      Gene Ontology 47
      Phenotypes 31
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:331972 Hummel D, et al., Celsr1 suppresses Wnt5a-mediated chemoattraction to prevent incorrect rostral migration of facial branchiomotor neurons. Development. 2022 Nov 15;149(22):dev200553

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory