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Dvl2 Gene Detail
Summary
  • Symbol
    Dvl2
  • Name
    dishevelled segment polarity protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:106613
    NCBI Gene: 13543
  • Gene Overview
    MyGene.info: DVL2
Location & Maps
more
  • Sequence Map
    Chr11:70000595-70012301 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11707 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.96 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    DVL2, dishevelled segment polarity protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DVL2, dishevelled segment polarity protein 2
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 1856
    neXtProt AC: NX_O14641

  • Chr Location
    17p13.1; chr17:7225342-7234548 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Dvl2 mouse models

Human Disease Mouse Models
       Transposition of the Great Arteries, Dextro-Looped 1; DTGA1   OMIM: 608808 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 2 alleles in 3 genetic backgrounds
    39 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    19
  • Chemically induced (other)
    1
  • Gene trapped
    8
  • Targeted
    5
  • Transgenic
    5
  • Genomic Mutations
    2 involving Dvl2
  • Incidental Mutations
Homozygous mice show incomplete penetrance of perinatal lethality with surviving mice being predominantly female. Defects include cardiovascular outflow and neural tube abnormalities, malformations of vertebrae and ribs, and irregular somite segmentation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006016 VEGA Gene Model | MGI Sequence Detail 11707 C57BL/6J ±  kb
transcript OTTMUST00000013481 VEGA | MGI Sequence Detail 2968 Not Applicable  
polypeptide OTTMUSP00000006246 VEGA | MGI Sequence Detail 736 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    90 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 92
    Genomic 2
    cDNA 84
    Primer pair 5
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-35070
References
more
  • Summaries
    All 109
    Developmental Gene Expression 40
    Diseases 1
    Gene Ontology 39
    Phenotypes 25
  • Earliest
    J:33550 Greco TL, et al., Dishevelled-2 maps to human chromosome 17 and distal to Wnt3a and vestigial tail (vt) on mouse chromosome 11. Mamm Genome. 1996 Jun;7(6):475-6
  • Latest
    J:227365 El-Hage P, et al., The Tumor-Suppressor WWOX and HDAC3 Inhibit the Transcriptional Activity of the beta-Catenin Coactivator BCL9-2 in Breast Cancer Cells. Mol Cancer Res. 2015 May;13(5):902-12

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory