About   Help   FAQ
Myo1c Gene Detail
Summary
  • Symbol
    Myo1c
  • Name
    myosin IC
  • Synonyms
    C80397, mm1beta, myosin-Ibeta, myr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:106612
    NCBI Gene: 17913
  • Gene Overview
    MyGene.info: MYO1C
Location & Maps
more
  • Sequence Map
    Chr11:75650504-75673910 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23407 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 45.92 cM, cytoband C-E1
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    MYO1C, myosin IC
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MYO1C, myosin IC
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MMIb, MMI-beta, myr2, NMI
  • Links
    NCBI Gene ID: 4641
    neXtProt AC: NX_O00159

  • Chr Location
    17p13.3; chr17:1464186-1492707 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    28
  • Chemically induced (other)
    1
  • Gene trapped
    20
  • Targeted
    7
  • Genomic Mutations
    2 involving Myo1c
  • Incidental Mutations
Mice homozygous for a knock-in (Y61G) mutation that sensitizes to N6-modified ADP analogs display altered fast adaption in vestibular hair cells. Mice homozygous for a nuclear isoform-specifc knock-out allele exhibit minor changes in bone marrow density and red blood cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006212 VEGA Gene Model | MGI Sequence Detail 23407 C57BL/6J ±  kb
transcript OTTMUST00000014011 VEGA | MGI Sequence Detail 4652 Not Applicable  
polypeptide OTTMUSP00000006509 VEGA | MGI Sequence Detail 1063 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    83 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 234
    Genomic 4
    cDNA 228
    Primer pair 1
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-35069, MGI:2144662
References
more
  • Summaries
    All 58
    Developmental Gene Expression 1
    Gene Ontology 12
    Phenotypes 16
  • Earliest
    J:35477 Hasson T, et al., Mapping of unconventional myosins in mouse and human. Genomics. 1996 Sep 15;36(3):431-9
  • Latest
    J:235308 Yu NK, et al., A transducible nuclear/nucleolar protein, mLLP, regulates neuronal morphogenesis and synaptic transmission. Sci Rep. 2016;6:22892

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/29/2016
MGI 6.06
The Jackson Laboratory