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Myo1c Gene Detail
Summary
  • Symbol
    Myo1c
  • Name
    myosin IC
  • Synonyms
    C80397, mm1beta, myosin-Ibeta, myr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:106612
    NCBI Gene: 17913
  • Alliance
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:75541330-75564736 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 45.92 cM, cytoband C-E1
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    83 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106612
protein coding gene Chr11:75541330-75565450 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018720
protein coding gene Chr11:76416121-76440627 (+)
A/J MGP_AJ_G0018686
protein coding gene Chr11:73568576-73591967 (+)
AKR/J MGP_AKRJ_G0018656
protein coding gene Chr11:75795155-75818638 (+)
BALB/cJ MGP_BALBcJ_G0018660
protein coding gene Chr11:73948546-73972706 (+)
C3H/HeJ MGP_C3HHeJ_G0018473
protein coding gene Chr11:75814090-75838438 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019111
protein coding gene Chr11:78829044-78859268 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016746
protein coding gene Chr11:70581232-70604565 (+)
CAST/EiJ MGP_CASTEiJ_G0018027
protein coding gene Chr11:76208986-76232878 (+)
CBA/J MGP_CBAJ_G0018443
protein coding gene Chr11:82278561-82304100 (+)
DBA/2J MGP_DBA2J_G0018552
protein coding gene Chr11:73172131-73196235 (+)
FVB/NJ MGP_FVBNJ_G0018542
protein coding gene Chr11:72735466-72759336 (+)
LP/J MGP_LPJ_G0018623
protein coding gene Chr11:76999207-77023000 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018568
protein coding gene Chr11:82816290-82841715 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019151
protein coding gene Chr11:76012338-76036079 (+)
PWK/PhJ MGP_PWKPhJ_G0017798
protein coding gene Chr11:73878938-73903157 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017589
protein coding gene Chr11:75563877-75587541 (+)
WSB/EiJ MGP_WSBEiJ_G0018080
protein coding gene Chr11:75823415-75848856 (+)



Homology
more
  • Human Ortholog
    MYO1C, myosin IC
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYO1C, myosin IC
  • Synonyms
    MMIb, MMI-beta, MyoIC, myr2, NMI
  • Links
    NCBI Gene ID: 4641
    neXtProt AC: NX_O00159
    UniProt: O00159

  • Chr Location
    17p13.3; chr17:1464186-1492686 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-in (Y61G) mutation that sensitizes to N6-modified ADP analogs display altered fast adaption in vestibular hair cells. Mice homozygous for a nuclear isoform-specifc knock-out allele exhibit minor changes in bone marrow density and red blood cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000017774 Ensembl Gene Model | MGI Sequence Detail 23407 C57BL/6J ±  kb
    transcript ENSMUST00000102505 Ensembl | MGI Sequence Detail 4652 Not Applicable  
    polypeptide ENSMUSP00000099563 Ensembl | MGI Sequence Detail 1063 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 235
      Genomic 4
      cDNA 229
      Primer pair 1
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-35069, MGI:2144662
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 1
      Gene Ontology 17
      Phenotypes 19
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory