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Prpf19
Gene Detail
 Symbol
Name
ID
Prpf19
PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)
MGI:106247
Synonyms D19Wsu55e, Prp19, PSO4, Snev
Feature Type protein coding gene
Genetic Map
Chromosome 19
7.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr19:10895231-10909559 bp, + strand
From NCBI annotation of GRCm38

  14329 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6421  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Prpf19

Human
homologs
Human Homolog PRPF19, pre-mRNA processing factor 19
NCBI Gene ID 27339
neXtProt AC  NX_Q9UMS4
Human Synonyms  hPSO4, NMP200, PRP19, PSO4, SNEV, UBOX4
Human Chr (Location)  11q12.2; chr11:60890547-60906589 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(8) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele die prior to implantation and have defective cell proliferation.
 
Interactions
Prpf19 interacts with 385 markers (Mir7-1, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process cellular response to DNA damage stimulus, DNA repair, ...
Component catalytic step 2 spliceosome, cytoplasm, ...
Function DNA binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (27)    Tissues (20)    Images (5)
Theiler Stages: 11, 17, 20
Assay TypeResults
RNA in situ 21
RT-PCR 6
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000024735 (Evidence)
Entrez Gene28000 (Evidence)
DFCITC1573212, TC1586094, TC1621894, TC1761880, TC1766154
DoTSDT.101148091, DT.101393573, DT.101713028, DT.94189594, DT.94189638, DT.94268265, DT.97415665, DT.97415669
NIA Mouse Gene IndexU019168, U019169, U261803
Consensus CDS ProjectCCDS57135.1, CCDS57136.1
International Mouse Knockout Project StatusPrpf19
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 28000 NCBI Gene Model | MGI Sequence Detail 14329 C57BL/6J ±  kb
transcript NM_001253843 RefSeq | MGI Sequence Detail 6218 C57BL/6 
polypeptide Q99KP6 UniProt | EBI | MGI Sequence Detail 504 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(104 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020472 G-protein beta WD-40 repeat
InterPro IPR013915 Pre-mRNA-splicing factor 19
InterPro IPR000772 Ricin B lectin domain
InterPro IPR003613 U box domain
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000013277 pre-mRNA-processing factor 19
Graphical View of Protein Domain Structure
References (Earliest) J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(43)
Other
accession IDs
MGD-MRK-33939, MGI:2147181, MGI:2147631

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory