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Prpf19
Gene Detail
Symbol

Name
ID
Prpf19
PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)
MGI:106247
Synonyms
D19Wsu55e, Prp19, PSO4, Snev
Feature Type
protein coding gene
Genetic Map
Chromosome 19
7.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr19:10895231-10909559 bp, + strand
From VEGA annotation of GRCm38

  14329 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6421  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PRPF19
Gene Tree: Prpf19

Human
homologs
PRPF19, pre-mRNA processing factor 19
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 27339
neXtProt AC: NX_Q9UMS4

Human Synonyms: hPSO4, NMP200, PRP19, PSO4, SNEV, UBOX4

Human Chr (Location): 11q12.2; chr11:60890547-60906589 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(8) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele die prior to implantation and have defective cell proliferation.
 
Interactions
Prpf19 interacts with 384 markers (Mir7-1, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (27)    Tissues (20)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 21
RT-PCR 6
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase prpf19    NEW 
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000046847 (Evidence)
Ensembl Gene Model ENSMUSG00000024735 (Evidence)
Entrez Gene 28000 (Evidence)
DFCI TC1586094, TC1573212, TC1621894, TC1766154, TC1761880
DoTS DT.101393573, DT.101713028, DT.101148091, DT.94189638, DT.94189594, DT.94268265, DT.97415669, DT.97415665
NIA Mouse Gene Index U019169, U019168, U261803
EC 6.3.2.-
Consensus CDS Project CCDS57135.1, CCDS57136.1
International Mouse Phenotyping Consortium Status Prpf19
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046847 VEGA Gene Model | MGI Sequence Detail 14329 C57BL/6J ±  kb
transcript OTTMUST00000121505 VEGA | MGI Sequence Detail 6035 Not Applicable 
polypeptide OTTMUSP00000066932 VEGA | MGI Sequence Detail 523 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(104 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020472 G-protein beta WD-40 repeat
InterPro IPR013915 Pre-mRNA-splicing factor 19
InterPro IPR000772 Ricin B lectin domain
InterPro IPR003613 U box domain
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000013277 pre-mRNA-processing factor 19
References
(Earliest) J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(45)
Other
accession IDs
MGD-MRK-33939, MGI:2147181, MGI:2147631

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory