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Capza3
Gene Detail
 Symbol
Name
ID
Capza3
capping protein (actin filament) muscle Z-line, alpha 3
MGI:106221
Synonyms 510-4, Cappa3, cp alpha3, Gsg3, repro32, Tex8
Feature Type protein coding gene
Genetic Map
Chromosome 6
69.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr6:140041557-140042778 bp, + strand
From VEGA annotation of GRCm38

  1222 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7253  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: actin-capping protein alpha chain
Gene Tree: Capza3

Human
homologs
Human Homolog CAPZA3, capping protein (actin filament) muscle Z-line, alpha 3
NCBI Gene ID 93661
neXtProt AC  NX_Q96KX2
Human Synonyms  CAPPA3, Gsg3
Human Chr (Location)  12p12.3; chr12:18738111-18739188 (+)  GRCh38
Alleles
and
phenotypes
All alleles(1) : Chemically induced (ENU)(1)
 
Males homozygous for an ENU-induced mutation are infertile, exhibit low epididymal sperm concentrations, and produce sperm with abnormally shaped heads and poor motility.
 
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process actin cytoskeleton organization, actin filament capping, ...
Component acrosomal vesicle, cortical cytoskeleton, ...
Function actin binding
External Resources: FuncBase
Expression
cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(11) Genomic(1) cDNA(10)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000023675 (Evidence)
Ensembl Gene ModelENSMUSG00000041791 (Evidence)
Entrez Gene12344 (Evidence)
UniGene12817
DFCITC1584833
DoTSDT.40139924
NIA Mouse Gene IndexU007512
Consensus CDS ProjectCCDS20672.1
International Mouse Knockout Project StatusCapza3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023675 VEGA Gene Model | MGI Sequence Detail 1222 C57BL/6J ±  kb
transcript OTTMUST00000057789 VEGA | MGI Sequence Detail 1222 Not Applicable 
polypeptide OTTMUSP00000027928 VEGA | MGI Sequence Detail 299 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms RFLP(2) : SNPs within 2kb(54 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017865 F-actin capping protein, alpha subunit, conserved site
InterPro IPR002189 WASH complex, F-actin capping protein, alpha subunit
Protein Ontology PR:000005031 F-actin-capping protein subunit alpha-3
References (Earliest) J:21735 Tanaka H, et al., Isolation and characterization of cDNA clones specifically expressed in testicular germ cells. FEBS Lett. 1994 Nov 21;355(1):4-10
(Latest) J:149233 Geyer CB, et al., A missense mutation in the Capza3 gene and disruption of F-actin organization in spermatids of repro32 infertile male mice. Dev Biol. 2009 Jun 1;330(1):142-52
All references(36)
Other
accession IDs
MGD-MRK-23797, MGD-MRK-33913, MGI:3590184

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory