Spink3
Gene Detail

Symbol Name ID

Spink3 serine peptidase inhibitor, Kazal type 3 MGI:106202

Synonyms

p12, prostatic secretory glycoprotein

Feature Type

protein coding gene

Genetic Map

Chromosome 18

23.47 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr18:43728069-43737237 bp, - strand From NCBI annotation of GRCm38   9169 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68300  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: pancreatic secretory trypsin inhibitor
Gene Tree: Spink3

Human homologs

Human Homolog		SPINK1, serine peptidase inhibitor, Kazal type 1
NCBI Gene ID		6690
neXtProt AC		NX_P00995
Human Synonyms		PCTT, PSTI, Spink3, TATI, TCP
Human Chr (Location)		5q32; chr5:147204143-147211260 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human SPINK1

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a disruption in this gene results in postnatal lethality, growth retardation, dehydration, autophagic degeneration of acinar cells resulting in pancreas trophy, small intestine degeneration, and a small spleen.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	negative regulation of calcium ion import, negative regulation of nitric oxide mediated signal transduction, ...
Component	extracellular region
Function	endopeptidase inhibitor activity, peptidase inhibitor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (20)    Tissues (11)    Images (14)
Theiler Stages: 13, 22, 23, 28

Assay Type	Results
RNA in situ	17
RT-PCR	3

cDNA source data(59)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(64) Genomic(2) cDNA(59) Primer pair(2) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000024503 (Evidence)
Entrez Gene	20730 (Evidence)
UniGene	272
DFCI	TC1573763, TC1629392
DoTS	DT.110786196, DT.110786233, DT.493884, DT.55206253, DT.99844877
Consensus CDS Project	CCDS37803.1
International Mouse Knockout Project Status	Spink3

Sequences

Length	Strain/Species
genomic	20730	NCBI Gene Model | MGI Sequence Detail	9169	C57BL/6J
transcript	NM_009258	RefSeq | MGI Sequence Detail	422	C57BL/6
polypeptide	P09036	UniProt | EBI | MGI Sequence Detail	80	Not Applicable

All sequences(23) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(122 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002350	Kazal domain
InterPro	IPR001239	Proteinase inhibitor I1, Kazal metazoa
Protein Ontology	PR:000015532	pancreatic secretory trypsin inhibitor

Graphical View of Protein Domain Structure

References

(Earliest) J:52103 Small JA, et al., Early regions of JC virus and BK virus induce distinct and tissue-specific tumors in transgenic mice. Proc Natl Acad Sci U S A. 1986 Nov;83(21):8288-92
(Latest) J:185331 Zalazar L, et al., SPINK3 modulates mouse sperm physiology through the reduction of nitric oxide level independently of its trypsin inhibitory activity. Reproduction. 2012 Mar;143(3):281-95
All references(39)

Other accession IDs

MGD-MRK-33893