About   Help   FAQ
Spink1 Gene Detail
Summary
  • Symbol
    Spink1
  • Name
    serine peptidase inhibitor, Kazal type 1
  • Synonyms
    p12, prostatic secretory glycoprotein, Spink3
  • Feature Type
    protein coding gene
  • IDs
    MGI:106202
    NCBI Gene: 20730
  • Gene Overview
    MyGene.info: SPINK1
Location & Maps
more
  • Sequence Map
    Chr18:43728069-43737237 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9169 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 23.47 cM, cytoband B3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SPINK1, serine peptidase inhibitor, Kazal type 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    SPINK1, serine peptidase inhibitor, Kazal type 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PCTT, PSTI, Spink3, TATI, TCP
  • Links
    NCBI Gene ID: 6690
    neXtProt AC: NX_P00995

  • Chr Location
    5q32; chr5:147824580-147839231 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human SPINK1 associations

Human Disease Mouse Models
       Pancreatitis, Hereditary; PCTT   OMIM: 167800
Tropical Calcific Pancreatitis   OMIM: 608189
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    5
  • Incidental Mutations
    APF
Mice homozygous for a disruption in this gene results in postnatal lethality, growth retardation, dehydration, autophagic degeneration of acinar cells resulting in pancreas trophy, small intestine degeneration, and a small spleen.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20730 NCBI Gene Model | MGI Sequence Detail 9169 C57BL/6J ±  kb
transcript NM_009258 RefSeq | MGI Sequence Detail 422 C57BL/6  
polypeptide P09036 UniProt | EBI | MGI Sequence Detail 80 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    154 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000015532 pancreatic secretory trypsin inhibitor
  • InterPro Domains
    IPR002350 Kazal domain
    IPR001239 Proteinase inhibitor I1, Kazal-type, metazoa
Molecular
Reagents
less
  • All nucleic 64
    Genomic 2
    cDNA 59
    Primer pair 2
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-33893
References
more
  • Summaries
    All 42
    Developmental Gene Expression 9
    Gene Ontology 8
    Phenotypes 7
  • Earliest
    J:52103 Small JA, et al., Early regions of JC virus and BK virus induce distinct and tissue-specific tumors in transgenic mice. Proc Natl Acad Sci U S A. 1986 Nov;83(21):8288-92
  • Latest
    J:219129 Ozaki N, et al., Autophagy regulation in pancreatic acinar cells is independent of epidermal growth factor receptor signaling. Biochem Biophys Res Commun. 2014 Mar 28;446(1):224-30

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory