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Spink3
Gene Detail
Symbol

Name
ID
Spink3
serine peptidase inhibitor, Kazal type 3
MGI:106202
Synonyms
p12, prostatic secretory glycoprotein
Feature Type
protein coding gene
Genetic Map
Chromosome 18
23.47 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:43728069-43737237 bp, - strand
From NCBI annotation of GRCm38

  9169 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68300  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: pancreatic secretory trypsin inhibitor
Gene Tree: Spink3

Human
homologs
Human Homolog SPINK1, serine peptidase inhibitor, Kazal type 1
NCBI Gene ID 6690
neXtProt AC  NX_P00995
Human Synonyms  PCTT, PSTI, Spink3, TATI, TCP
Human Chr (Location)  5q32; chr5:147824580-147839231 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human SPINK1
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from APF )
 
Mice homozygous for a disruption in this gene results in postnatal lethality, growth retardation, dehydration, autophagic degeneration of acinar cells resulting in pancreas trophy, small intestine degeneration, and a small spleen.
 
Interactions
Spink3 interacts with 17 markers (Mir33, Mir181a-1, Mir181a-2, ...)
Expression
Literature Summary: (8 records)
Data Summary: Results (20)    Tissues (11)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 17
RT-PCR 3
cDNA source data(59)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(64) Genomic(2) cDNA(59) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000024503 (Evidence)
Entrez Gene20730 (Evidence)
UniGene272
DFCITC1573763, TC1629392
DoTSDT.110786196, DT.110786233, DT.493884, DT.55206253, DT.99844877
Consensus CDS ProjectCCDS37803.1
International Mouse Knockout Project StatusSpink3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20730 NCBI Gene Model | MGI Sequence Detail 9169 C57BL/6J ±  kb
transcript NM_009258 RefSeq | MGI Sequence Detail 422 C57BL/6 
polypeptide P09036 UniProt | EBI | MGI Sequence Detail 80 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(154 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002350 Kazal domain
InterPro IPR001239 Proteinase inhibitor I1, Kazal metazoa
Protein Ontology PR:000015532 pancreatic secretory trypsin inhibitor
Graphical View of Protein Domain Structure
References
(Earliest) J:52103 Small JA, et al., Early regions of JC virus and BK virus induce distinct and tissue-specific tumors in transgenic mice. Proc Natl Acad Sci U S A. 1986 Nov;83(21):8288-92
(Latest) J:205182 Sakata K, et al., Generation and analysis of serine protease inhibitor kazal type 3-cre driver mice. Exp Anim. 2014;63(1):45-53
All references(41)
Other
accession IDs
MGD-MRK-33893

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory