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Spink1
Gene Detail
Symbol

Name
ID
Spink1
serine peptidase inhibitor, Kazal type 1
MGI:106202
Synonyms
p12, prostatic secretory glycoprotein, Spink3
Feature Type
protein coding gene
Genetic Map
Chromosome 18
23.47 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:43728069-43737237 bp, - strand
From NCBI annotation of GRCm38

  9169 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68300  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: SPINK1
Protein SuperFamily: pancreatic secretory trypsin inhibitor
Gene Tree: Spink1

Human
homologs
SPINK1, serine peptidase inhibitor, Kazal type 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6690
neXtProt AC: NX_P00995

Human Synonyms: PCTT, PSTI, Spink3, TATI, TCP

Human Chr (Location): 5q32; chr5:147824580-147839231 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human SPINK1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from APF )
 
Mice homozygous for a disruption in this gene results in postnatal lethality, growth retardation, dehydration, autophagic degeneration of acinar cells resulting in pancreas trophy, small intestine degeneration, and a small spleen.
 
Interactions
Spink1 interacts with 17 markers (Mir33, Mir181a-1, Mir181a-2, ...)
Expression
Literature Summary: (9 records)
Data Summary: Results (20)    Tissues (11)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 17
RT-PCR 3
cDNA source data(59)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(64) Genomic(2) cDNA(59) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000024503 (Evidence)
Entrez Gene 20730 (Evidence)
UniGene 272
DFCI TC1573763, TC1629392
DoTS DT.493884, DT.110786233, DT.110786196, DT.99844877, DT.55206253
Consensus CDS Project CCDS37803.1
International Mouse Phenotyping Consortium Status Spink1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20730 NCBI Gene Model | MGI Sequence Detail 9169 C57BL/6J ±  kb
transcript NM_009258 RefSeq | MGI Sequence Detail 422 C57BL/6 
polypeptide P09036 UniProt | EBI | MGI Sequence Detail 80 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(154 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002350 Kazal domain
InterPro IPR001239 Proteinase inhibitor I1, Kazal metazoa
Protein Ontology PR:000015532 pancreatic secretory trypsin inhibitor
Graphical View of Protein Domain Structure
References
(Earliest) J:52103 Small JA, et al., Early regions of JC virus and BK virus induce distinct and tissue-specific tumors in transgenic mice. Proc Natl Acad Sci U S A. 1986 Nov;83(21):8288-92
(Latest) J:219129 Ozaki N, et al., Autophagy regulation in pancreatic acinar cells is independent of epidermal growth factor receptor signaling. Biochem Biophys Res Commun. 2014 Mar 28;446(1):224-30
All references(43)
Other
accession IDs
MGD-MRK-33893

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory