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Lama5
Gene Detail
Symbol

Name
ID
Lama5
laminin, alpha 5
MGI:105382
Synonyms
mKIAA0533
Feature Type
protein coding gene
Genetic Map
Chromosome 2
102.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr2:180176373-180225859 bp, - strand
From VEGA annotation of GRCm38

  49487 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4060  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Lama5

Human
homologs
Human Homolog LAMA5, laminin, alpha 5
NCBI Gene ID 3911
neXtProt AC  NX_O15230
Human Chr (Location)  20q13.2-q13.3; chr20:62309060-62367312 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(50) : Gene trapped(44) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit disrupted basal laminae leading to exencephaly, syndactyly, placentopathy, kidney defects, abnormal lobar septation with absence of a visceral pleural membrane, and lethality in late gestation.
 
Phenotype Images(4)
Interactions
Lama5 interacts with 120 markers (Mir7-2, Mir7b, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process branching involved in salivary gland morphogenesis, branching involved in ureteric bud morphogenesis, ...
Component basal lamina, basement membrane, ...
Function integrin binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (76 records)
Data Summary: Results (313)    Tissues (101)    Images (40)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 32
RNA in situ 281
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) Genomic(4) cDNA(18) Primer pair(2) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000016271 (Evidence)
Ensembl Gene ModelENSMUSG00000015647 (Evidence)
Entrez Gene16776 (Evidence)
DFCITC1602784, TC1597526
DoTSDT.102549031, DT.101376710, DT.40181881, DT.490136, DT.97372921
NIA Mouse Gene IndexU023758
PDB2Y38
Consensus CDS ProjectCCDS38375.1
International Mouse Knockout Project StatusLama5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016271 VEGA Gene Model | MGI Sequence Detail 49487 C57BL/6J ±  kb
transcript OTTMUST00000039036 VEGA | MGI Sequence Detail 11388 Not Applicable 
polypeptide OTTMUSP00000017438 VEGA | MGI Sequence Detail 3718 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(6) UniProt(7)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(323 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR013032 EGF-like, conserved site
InterPro IPR002049 EGF-like, laminin
InterPro IPR018031 Laminin B, subgroup
InterPro IPR000034 Laminin B type IV
InterPro IPR001791 Laminin G domain
InterPro IPR009254 Laminin I
InterPro IPR010307 Laminin II
InterPro IPR008211 Laminin, N-terminal
Protein Ontology PR:000009654 laminin subunit alpha-5
References
(Earliest) J:29907 Miner JH, et al., Molecular cloning of a novel laminin chain, alpha 5, and widespread expression in adult mouse tissues. J Biol Chem. 1995 Dec 1;270(48):28523-6
(Latest) J:203643 Radmanesh F, et al., Mutations in LAMB1 cause cobblestone brain malformation without muscular or ocular abnormalities. Am J Hum Genet. 2013 Mar 7;92(3):468-74
All references(146)
Other
accession IDs
MGD-MRK-33051, MGI:2138757, MGI:2138758, MGI:2139098

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory