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Cbx1
Gene Detail
Symbol

Name
ID
Cbx1
chromobox 1
MGI:105369
Synonyms
Cbx-rs2, E430007M08Rik, HP1B, Hp1beta, M31, MOD1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
60.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr11:96789127-96808640 bp, + strand
From VEGA annotation of GRCm38

  19514 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:89116  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: heterochromatin protein 1 (HP1)
Gene Tree: Cbx1

Human
homologs
Human Homolog CBX1, chromobox homolog 1
NCBI Gene ID 10951
neXtProt AC  NX_P83916
Human Synonyms  CBX, HP1-BETA, HP1Hsbeta, HP1Hs-beta, M31, MOD1, p25beta
Human Chr (Location)  17q21.32; chr17:48070052-48101521 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(245) : Gene trapped(242) Targeted(3)
Incidental mutations (data from APF )
 
An uncharacterized gene trap insertion does not result in an obvious phenotype during the observation period early in life, although abnormalities may still develop at older age.
 
Interactions
Cbx1 interacts with 131 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process negative regulation of transcription, DNA-templated
Component chromatin, chromocenter, ...
Function enzyme binding, histone methyltransferase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (273)    Tissues (142)    Images (45)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 243
Northern blot 25
RT-PCR 5
cDNA source data(98)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(103) Genomic(1) cDNA(99) Primer pair(3)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000001636 (Evidence)
Ensembl Gene ModelENSMUSG00000018666 (Evidence)
Entrez Gene12412 (Evidence)
UniGene29055
DFCITC1596325, TC1588693, TC1578046, TC1606437, TC1693672, TC1686040, TC1660965
DoTSDT.101407718, DT.101407721, DT.91286147, DT.101736428, DT.99860555, DT.94338009
NIA Mouse Gene IndexU013257
PDB1S4Z, 1GUW, 1DZ1, 1AP0
Consensus CDS ProjectCCDS25303.1
International Mouse Knockout Project StatusCbx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001636 VEGA Gene Model | MGI Sequence Detail 19514 C57BL/6J ±  kb
transcript OTTMUST00000003219 VEGA | MGI Sequence Detail 1251 Not Applicable 
polypeptide OTTMUSP00000001556 VEGA | MGI Sequence Detail 185 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(15) UniProt(5)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023780 Chromo domain
InterPro IPR023779 Chromo domain, conserved site
InterPro IPR016197 Chromo domain-like
InterPro IPR000953 Chromo domain/shadow
InterPro IPR017984 Chromo domain subgroup
InterPro IPR008251 Chromo shadow domain
Protein Ontology PR:000005082 chromobox protein homolog 1
References
(Earliest) J:32398 Singh PB, et al., A sequence motif found in a Drosophila heterochromatin protein is conserved in animals and plants. Nucleic Acids Res. 1991 Feb 25;19(4):789-94
(Latest) J:201469 Sridharan R, et al., Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1gamma in reprogramming to pluripotency. Nat Cell Biol. 2013 Jul;15(7):872-82
All references(74)
Other
accession IDs
MGD-MRK-1790, MGD-MRK-33038, MGI:2442882

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory