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Cbx1 Gene Detail
Summary
  • Symbol
    Cbx1
  • Name
    chromobox 1
  • Synonyms
    Cbx-rs2, E430007M08Rik, HP1B, Hp1beta, M31, MOD1
  • Feature Type
    protein coding gene
  • IDs
    MGI:105369
    NCBI Gene: 12412
  • Gene Overview
    MyGene.info: CBX1
Location & Maps
more
  • Sequence Map
    Chr11:96789127-96808640 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19514 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 60.11 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    CBX1, chromobox 1
  • Vertebrate Orthologs
    12
  • Human Ortholog
    CBX1, chromobox 1
    Orthology source: HomoloGene
  • Synonyms
    CBX, HP1-BETA, HP1Hsbeta, HP1Hs-beta, M31, MOD1, p25beta
  • Links
    NCBI Gene ID: 10951
    neXtProt AC: NX_P83916

  • Chr Location
    17q21.32; chr17:48070052-48101521 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    247
  • Gene trapped
    243
  • Targeted
    4
  • Genomic Mutations
    1 involving Cbx1
  • Incidental Mutations
    APF
An uncharacterized gene trap insertion does not result in an obvious phenotype during the observation period early in life, although abnormalities may still develop at older age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001636 VEGA Gene Model | MGI Sequence Detail 19514 C57BL/6J ±  kb
transcript OTTMUST00000003219 VEGA | MGI Sequence Detail 1251 Not Applicable  
polypeptide OTTMUSP00000001556 VEGA | MGI Sequence Detail 185 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    149 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 103
    Genomic 1
    cDNA 99
    Primer pair 3

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-1790, MGD-MRK-33038, MGI:2442882
References
more
  • Summaries
    All 73
    Developmental Gene Expression 17
    Gene Ontology 15
    Phenotypes 17
  • Earliest
    J:32398 Singh PB, et al., A sequence motif found in a Drosophila heterochromatin protein is conserved in animals and plants. Nucleic Acids Res. 1991 Feb 25;19(4):789-94
  • Latest
    J:228085 Hein MY, et al., A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances. Cell. 2015 Oct 22;163(3):712-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory