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Atp2b2
Gene Detail
Symbol

Name
ID
Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
MGI:105368
Synonyms
D6Abb2e, Gena300, jog, PMCA2, Tmy, wms
Feature Type
protein coding gene
Genetic Map
Chromosome 6
52.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(23)
Sequence Map
Chr6:113745669-114042613 bp, - strand
From VEGA annotation of GRCm38

  296945 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56150  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ATP2B2
Protein SuperFamily: Na(+)/K(+)-transporting ATPase alpha chain
Gene Tree: Atp2b2

Human
homologs
ATP2B2, ATPase, Ca++ transporting, plasma membrane 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 491
neXtProt AC: NX_Q01814

Human Synonyms: PMCA2, PMCA2a, PMCA2i

Human Chr (Location): 3p25.3; chr3:10324023-10707993 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ATP2B2

Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Chemically induced (ENU)(7) Gene trapped(2) Spontaneous(8) Targeted(3)
Genomic Mutations involving Atp2b2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutants exhibit slower growth, balance problems, and deafness, associated with cerebellar abnormalities, an absence of otoconia, and abnormalities of the organ of Corti. Heterozygotes exhibit appreciable age-dependent hearing loss.
 
Phenotype Images(4)
Interactions
Atp2b2 interacts with 391 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (87 annotations)
Process auditory receptor cell stereocilium organization, calcium ion export, ...
Component apical plasma membrane, cell, ...
Function acetylcholine receptor binding, ATP binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (167)    Tissues (107)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 155
Western blot 5
RT-PCR 7
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase atp2b4 ; ZFIN atp2b2    NEW 
Molecular
reagents
All nucleic(22) Genomic(9) cDNA(11) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000018967 (Evidence)
Ensembl Gene Model ENSMUSG00000030302 (Evidence)
Entrez Gene 11941 (Evidence)
DFCI TC1653818, TC1623719, TC1580453
DoTS DT.94171484, DT.91322618, DT.60105276, DT.55210906, DT.110498239, DT.103564295, DT.97332447
NIA Mouse Gene Index U027743
EC 3.6.3.8
Consensus CDS Project CCDS20433.1
International Mouse Phenotyping Consortium Status Atp2b2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018967 VEGA Gene Model | MGI Sequence Detail 296945 C57BL/6J ±  kb
transcript OTTMUST00000045567 VEGA | MGI Sequence Detail 4586 Not Applicable 
polypeptide OTTMUSP00000020493 VEGA | MGI Sequence Detail 1243 Not Applicable 

For the selected sequences
All sequences(88) RefSeq(26) UniProt(7)
Polymorphisms
SNPs within 2kb(2267 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022141 Calcium transporting P-type ATPase, C-terminal, plasma membrane
InterPro IPR006408 Calcium-transporting P-type ATPase, subfamily IIB
InterPro IPR001757 Cation-transporting P-type ATPase
InterPro IPR006068 Cation-transporting P-type ATPase, C-terminal
InterPro IPR004014 Cation-transporting P-type ATPase, N-terminal
InterPro IPR023214 HAD-like domain
InterPro IPR008250 P-type ATPase, A domain
InterPro IPR023299 P-type ATPase, cytoplasmic domain N
InterPro IPR018303 P-type ATPase, phosphorylation site
InterPro IPR023298 P-type ATPase, transmembrane domain
Protein Ontology PR:000004446 plasma membrane calcium-transporting ATPase 2
References
(Earliest) J:14114 Lane PW, Deaf waddler (dfw). Mouse News Lett. 1987;77:129
(Latest) J:220660 Watson CJ, et al., A new Atp2b2 deafwaddler allele, dfw(i5), interacts strongly with Cdh23 and other auditory modifiers. Hear Res. 2013 Oct;304:41-8
All references(97)
Other
accession IDs
MGD-MRK-15437, MGD-MRK-15460, MGD-MRK-32111, MGD-MRK-33037, MGD-MRK-8835, MGI:2158365, MGI:3664090, MGI:5490332, MGI:94888, MGI:98965

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory