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Atp2b2
Gene Detail
Symbol

Name
ID
Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
MGI:105368
Synonyms
D6Abb2e, Gena300, jog, PMCA2, Tmy, wms
Feature Type
protein coding gene
Genetic Map
Chromosome 6
52.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(23)
Sequence Map
Chr6:113745669-114042613 bp, - strand
From VEGA annotation of GRCm38

  296945 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56150  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Na(+)/K(+)-transporting ATPase alpha chain
Gene Tree: Atp2b2

Human
homologs
Human Homolog ATP2B2, ATPase, Ca++ transporting, plasma membrane 2
NCBI Gene ID 491
neXtProt AC  NX_Q01814
Human Synonyms  PMCA2, PMCA2a, PMCA2i
Human Chr (Location)  3p25.3; chr3:10324023-10707955 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ATP2B2
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Chemically induced (ENU)(5) Gene trapped(2) Spontaneous(7) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants exhibit slower growth, balance problems, and deafness, associated with cerebellar abnormalities, an absence of otoconia, and abnormalities of the organ of Corti. Heterozygotes exhibit appreciable age-dependent hearing loss.
 
Phenotype Images(3)
Interactions
Atp2b2 interacts with 392 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (84 annotations)
Process ATP catabolic process, auditory receptor cell stereocilium organization, ...
Component apical plasma membrane, cell, ...
Function acetylcholine receptor binding, ATP binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (167)    Tissues (107)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 155
Western blot 5
RT-PCR 7
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(9) cDNA(11) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000018967 (Evidence)
Ensembl Gene ModelENSMUSG00000030302 (Evidence)
Entrez Gene11941 (Evidence)
DFCITC1580453, TC1623719, TC1653818
DoTSDT.103564295, DT.110498239, DT.55210906, DT.60105276, DT.91322618, DT.94171484, DT.97332447
NIA Mouse Gene IndexU027743
EC3.6.3.8
Consensus CDS ProjectCCDS20433.1
International Mouse Knockout Project StatusAtp2b2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018967 VEGA Gene Model | MGI Sequence Detail 296945 C57BL/6J ±  kb
transcript OTTMUST00000045567 VEGA | MGI Sequence Detail 4586 Not Applicable 
polypeptide OTTMUSP00000020493 VEGA | MGI Sequence Detail 1243 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(4) UniProt(7)
Polymorphisms
SNPs within 2kb(2267 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022141 Calcium transporting P-type ATPase, C-terminal, plasma membrane
InterPro IPR006408 Calcium-transporting P-type ATPase, subfamily IIB
InterPro IPR001757 Cation-transporting P-type ATPase
InterPro IPR006068 Cation-transporting P-type ATPase, C-terminal
InterPro IPR004014 Cation-transporting P-type ATPase, N-terminal
InterPro IPR023214 HAD-like domain
InterPro IPR008250 P-type ATPase, A domain
InterPro IPR023299 P-type ATPase, cytoplasmic domain N
InterPro IPR018303 P-type ATPase, phosphorylation site
InterPro IPR023298 P-type ATPase, transmembrane domain
Protein Ontology PR:000004446 plasma membrane calcium-transporting ATPase 2
References
(Earliest) J:14114 Lane PW, Deaf waddler (dfw). Mouse News Lett. 1987;77:129
(Latest) J:199859 Carpinelli MR, et al., Two ENU-induced alleles of Atp2b2 cause deafness in mice. PLoS One. 2013;8(6):e67479
All references(95)
Other
accession IDs
MGD-MRK-15437, MGD-MRK-15460, MGD-MRK-32111, MGD-MRK-33037, MGD-MRK-8835, MGI:2158365, MGI:3664090, MGI:5490332, MGI:94888, MGI:98965

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory