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Efs Gene Detail
Summary
  • Symbol
    Efs
  • Name
    embryonal Fyn-associated substrate
  • Feature Type
    protein coding gene
  • IDs
    MGI:105311
    NCBI Gene: 13644
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:54916535-54926126 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9592 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 27.99 cM, cytoband C1
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    EFS, embryonal Fyn-associated substrate
  • Vertebrate Orthologs
    7
  • Human Ortholog
    EFS, embryonal Fyn-associated substrate
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAS3, CASS3, EFS1, EFS2, HEFS, SIN
  • Links
    NCBI Gene ID: 10278
    neXtProt AC: NX_O43281
    UniProt: O43281

  • Chr Location
    14q11.2; chr14:23356400-23365633 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Efs mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene display an increased inflammatory response characterized by excessive T cell responses, enhanced cytokine secretion and antibody production, and intestinal, kidney, liver, and lung inflammation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022203 Ensembl Gene Model | MGI Sequence Detail 9592 C57BL/6J ±  kb
    transcript ENSMUST00000022813 Ensembl | MGI Sequence Detail 2705 Not Applicable  
    polypeptide ENSMUSP00000022813 Ensembl | MGI Sequence Detail 560 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      76 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 75
      cDNA 74
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-32352
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 5
      Phenotypes 7
    • Earliest
      J:30264 Ishino M, et al., Molecular cloning of a cDNA encoding a phosphoprotein, Efs, which contains a Src homology 3 domain and associates with Fyn. Oncogene. 1995 Dec 7;11(11):2331-8
    • Latest
      J:241012 Lee M, et al., Tcf7l2 plays crucial roles in forebrain development through regulation of thalamic and habenular neuron identity and connectivity. Dev Biol. 2017 Apr 01;424(1):62-76

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory