About   Help   FAQ
Efs Gene Detail
Summary
  • Symbol
    Efs
  • Name
    embryonal Fyn-associated substrate
  • Feature Type
    protein coding gene
  • IDs
    MGI:105311
    NCBI Gene: 13644
Location & Maps
more
  • Sequence Map
    Chr14:54916543-54926788 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10246 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 27.99 cM, cytoband C1
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    EFS, embryonal Fyn-associated substrate
  • Vertebrate Orthologs
    7
  • Human Ortholog
    EFS, embryonal Fyn-associated substrate
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CAS3, CASS3, EFS1, EFS2, HEFS, SIN
  • Links
    NCBI Gene ID: 10278
    neXtProt AC: NX_O43281

  • Chr Location
    14q11.2; chr14:23356400-23365633 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    1
  • Genomic Mutations
    1 involving Efs
  • Incidental Mutations
Mice homozygous for a disruption in this gene display an increased inflammatory response characterized by excessive T cell responses, enhanced cytokine secretion and antibody production, and intestinal, kidney, liver, and lung inflammation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 13644 NCBI Gene Model | MGI Sequence Detail 10246 C57BL/6J ±  kb
transcript NM_010112 RefSeq | MGI Sequence Detail 3571 C57BL/6  
polypeptide Q64355 UniProt | EBI | MGI Sequence Detail 560 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    76 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 75
    cDNA 74
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-32352
References
more
  • Summaries
    All 28
    Developmental Gene Expression 6
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:30264 Ishino M, et al., Molecular cloning of a cDNA encoding a phosphoprotein, Efs, which contains a Src homology 3 domain and associates with Fyn. Oncogene. 1995 Dec 7;11(11):2331-8
  • Latest
    J:231595 Gurdziel K, et al., Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Dev Dyn. 2016 May;245(5):614-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory