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Nin Gene Detail
Summary
  • Symbol
    Nin
  • Name
    ninein
  • Synonyms
    3110068G20Rik, mKIAA1565
  • Feature Type
    protein coding gene
  • IDs
    MGI:105108
    NCBI Gene: 18080
  • Gene Overview
    MyGene.info: NIN
Location & Maps
more
  • Sequence Map
    Chr12:70011435-70102854 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      91420 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 28.94 cM, cytoband C3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    NIN, ninein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NIN, ninein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SCKL7
  • Links
    NCBI Gene ID: 51199
    neXtProt AC: NX_Q8N4C6

  • Chr Location
    14q22.1; chr14:50719763-50831165 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 40632
    1 human;1 mouse;2 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog
  • HCOP
    human homology predictions: NIN
  • Gene Tree
    Nin
Human Diseases
more
  • Diseases
    1 with human NIN associations

Human Disease Mouse Models
       Seckel Syndrome 7; SCKL7   OMIM: 614851
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Nin
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037170 VEGA Gene Model | MGI Sequence Detail 91420 C57BL/6J ±  kb
transcript OTTMUST00000095750 VEGA | MGI Sequence Detail 9654 Not Applicable  
polypeptide OTTMUSP00000053440 VEGA | MGI Sequence Detail 2113 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1324 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 119
    cDNA 118
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-32148, MGI:1920448, MGI:2144801, MGI:2144962
References
more
  • Summaries
    All 51
    Developmental Gene Expression 10
    Gene Ontology 19
    Phenotypes 4
  • Earliest
    J:31172 Bouckson-Castaing V, et al., Molecular characterisation of ninein, a new coiled-coil protein of the centrosome. J Cell Sci. 1996 Jan;109(Pt 1):179-90
  • Latest
    J:225786 Waters AM, et al., The kinetochore protein, CENPF, is mutated in human ciliopathy and microcephaly phenotypes. J Med Genet. 2015 Mar;52(3):147-56

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory