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Ahr Gene Detail
Summary
  • Symbol
    Ahr
  • Name
    aryl-hydrocarbon receptor
  • Synonyms
    Ah, Ahh, Ahre, bHLHe76, dioxin receptor, In
  • Feature Type
    protein coding gene
  • IDs
    MGI:105043
    NCBI Gene: 11622
  • Gene Overview
    MyGene.info: AHR
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr12:35497974-35535038 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      37065 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 15.78 cM
  • Mapping Data
    37 experiments
Homology
more
  • Human Ortholog
    AHR, aryl hydrocarbon receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AHR, aryl hydrocarbon receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bHLHe76
  • Links
    NCBI Gene ID: 196
    neXtProt AC: NX_P35869
    UniProt: P35869

  • Chr Location
    7p21.1; chr7:17298652-17346151 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1224
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: AHR
  • Gene Tree
    Ahr
Human Diseases
more
  • Diseases
    1 with Ahr mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    132 phenotypes from 13 alleles in 27 genetic backgrounds
    10 phenotypes from multigenic genotypes
    8 images
    239 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for null or hypomorphic alleles do not respond to cyclic compounds (e.g., dioxin) and are resistant to their teratogenic effects. Depending on the allele, null mutants may also have liver defects, impaired female fertility, neonatal or postnatal lethality, and spleen abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000036999 VEGA Gene Model | MGI Sequence Detail 37065 C57BL/6J ±  kb
    transcript OTTMUST00000095140 VEGA | MGI Sequence Detail 5548 Not Applicable  
    polypeptide OTTMUSP00000053052 VEGA | MGI Sequence Detail 805 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      592 from dbSNP Build 142
    • PCR
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 87
      Genomic 10
      cDNA 72
      Primer pair 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11402, MGD-MRK-1198, MGD-MRK-1219, MGD-MRK-32082, MGI:895073
    References
    more
    • Summaries
      All 465
      Developmental Gene Expression 20
      Diseases 1
      Gene Ontology 31
      Phenotypes 239
    • Earliest
      J:84245 Poel WE, et al., Comparative susceptibilities of seven inbred strains of mice to qualified applications of 3, 4-benzpyrene. Proc Am Assoc Cancer Res. 1958;2:335
    • Latest
      J:259801 Klinefelter K, et al., Genetic differences in the aryl hydrocarbon receptor and CYP1A2 affect sensitivity to developmental polychlorinated biphenyl exposure in mice: relevance to studies of human neurological disorders. Mamm Genome. 2018 Feb;29(1-2):112-127

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory