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Ahr
Gene Detail
Symbol

Name
ID
Ahr
aryl-hydrocarbon receptor
MGI:105043
Synonyms
Ah, Ahh, Ahre, bHLHe76, dioxin receptor, In
Feature Type
protein coding gene
Genetic Map
Chromosome 12
15.78 cM
Detailed Genetic Map ± 1 cM


Mapping data(37)
Sequence Map
Chr12:35497974-35535038 bp, - strand
From VEGA annotation of GRCm38

  37065 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1224  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AHR
Gene Tree: Ahr

Human
homologs
AHR, aryl hydrocarbon receptor
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 196
neXtProt AC: NX_P35869

Human Synonyms: bHLHe76

Human Chr (Location): 7p15; chr7:17298652-17346151 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Targeted(12)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for null or hypomorphic alleles do not respond to cyclic compounds (e.g., dioxin) and are resistant to their teratogenic effects. Depending on the allele, null mutants may also have liver defects, impaired female fertility, neonatal or postnatal lethality, and spleen abnormalities.
 
Phenotype Images(8)
Interactions
Ahr interacts with 380 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (103 annotations)
Process B-1 B cell homeostasis, B cell differentiation, ...
Component aryl hydrocarbon receptor complex, cytoplasm, ...
Function aryl hydrocarbon receptor activity, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (209)    Tissues (139)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 186
RT-PCR 23
cDNA source data(71)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA AHR ; Xenbase ahr ; ZFIN ahr1a    NEW 
Molecular
reagents
All nucleic(89) Genomic(10) cDNA(72) Primer pair(5) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000036999 (Evidence)
Ensembl Gene Model ENSMUSG00000019256 (Evidence)
Entrez Gene 11622 (Evidence)
UniGene 341377
DFCI TC1740581, TC1618782, TC1602896
DoTS DT.101135033, DT.101125370, DT.101353216, DT.94402283
NIA Mouse Gene Index U013861
PDB 4M4X
Consensus CDS Project CCDS36434.1
International Mouse Phenotyping Consortium Status Ahr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036999 VEGA Gene Model | MGI Sequence Detail 37065 C57BL/6J ±  kb
transcript OTTMUST00000095140 VEGA | MGI Sequence Detail 5548 Not Applicable 
polypeptide OTTMUSP00000053052 VEGA | MGI Sequence Detail 805 Not Applicable 

For the selected sequences
All sequences(84) RefSeq(2) UniProt(15)
Polymorphisms
PCR(1) : SNPs within 2kb(622 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR001610 PAC motif
InterPro IPR000014 PAS domain
InterPro IPR013767 PAS fold
InterPro IPR013655 PAS fold-3
Protein Ontology PR:000003858 aryl hydrocarbon receptor
References
(Earliest) J:84245 Poel WE, et al., Comparative susceptibilities of seven inbred strains of mice to qualified applications of 3, 4-benzpyrene. Proc Am Assoc Cancer Res. 1958;2:335
(Latest) J:221149 Lee YH, et al., Aryl hydrocarbon receptor mediates both proinflammatory and anti-inflammatory effects in lipopolysaccharide-activated microglia. Glia. 2015 Jul;63(7):1138-54
All references(388)
Other
accession IDs
MGD-MRK-11402, MGD-MRK-1198, MGD-MRK-1219, MGD-MRK-32082, MGI:895073

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory