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Ahr Gene Detail
Summary
  • Symbol
    Ahr
  • Name
    aryl-hydrocarbon receptor
  • Synonyms
    Ah, Ahh, Ahre, bHLHe76, dioxin receptor, In
  • Feature Type
    protein coding gene
  • IDs
    MGI:105043
    NCBI Gene: 11622
  • Gene Overview
    MyGene.info: AHR
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:35497979-35534989 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 15.78 cM
  • Mapping Data
    37 experiments
Strain
Comparison
more
  • SNPs within 2kb
    592 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105043
protein coding gene Chr12:35497974-35535038 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019684
protein coding gene Chr12:33704146-33739715 (-)
A/J MGP_AJ_G0019650
protein coding gene Chr12:32653614-32690786 (-)
AKR/J MGP_AKRJ_G0019621
protein coding gene Chr12:33679101-33714583 (-)
BALB/cJ MGP_BALBcJ_G0019628
protein coding gene Chr12:32854836-32890748 (-)
C3H/HeJ MGP_C3HHeJ_G0019432
protein coding gene Chr12:33593828-33630332 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020075
protein coding gene Chr12:34648560-34688914 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017700
protein coding gene Chr12:31790715-31822696 (-)
CAST/EiJ MGP_CASTEiJ_G0018986
protein coding gene Chr12:28659191-28696008 (-)
CBA/J MGP_CBAJ_G0019404
protein coding gene Chr12:35800254-35838163 (-)
DBA/2J MGP_DBA2J_G0019517
protein coding gene Chr12:32500547-32536239 (-)
FVB/NJ MGP_FVBNJ_G0019506
protein coding gene Chr12:32225792-32264124 (-)
LP/J MGP_LPJ_G0019587
protein coding gene Chr12:33777886-33816155 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019542
protein coding gene Chr12:35467603-35515249 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020115
protein coding gene Chr12:33185712-33222388 (-)
PWK/PhJ MGP_PWKPhJ_G0018753
protein coding gene Chr12:27194283-27230508 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018542
protein coding gene Chr12:27808596-27846055 (-)
WSB/EiJ MGP_WSBEiJ_G0019036
protein coding gene Chr12:33433057-33468926 (-)



Homology
more
  • Human Ortholog
    AHR, aryl hydrocarbon receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AHR, aryl hydrocarbon receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bHLHe76
  • Links
    NCBI Gene ID: 196
    neXtProt AC: NX_P35869
    UniProt: P35869

  • Chr Location
    7p21.1; chr7:17298652-17346151 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1224
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: AHR
  • Gene Tree
    Ahr
Human Diseases
more
  • Diseases
    1 with Ahr mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    139 phenotypes from 12 alleles in 26 genetic backgrounds
    10 phenotypes from multigenic genotypes
    8 images
    254 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for null or hypomorphic alleles do not respond to cyclic compounds (e.g., dioxin) and are resistant to their teratogenic effects. Depending on the allele, null mutants may also have liver defects, impaired female fertility, neonatal or postnatal lethality, and spleen abnormalities. Conditional homozygous KO in the retina leads to retinal degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11622 NCBI Gene Model | MGI Sequence Detail 37011 C57BL/6J ±  kb
    transcript NM_013464 RefSeq | MGI Sequence Detail 5494 C57BL/6  
    polypeptide Q8R4S5 UniProt | EBI | MGI Sequence Detail 883 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 88
      Genomic 10
      cDNA 73
      Primer pair 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11402, MGD-MRK-1198, MGD-MRK-1219, MGD-MRK-32082, MGI:895073
    References
    more
    • Summaries
      All 484
      Developmental Gene Expression 22
      Diseases 1
      Gene Ontology 34
      Phenotypes 254
    • Earliest
      J:84245 Poel WE, et al., Comparative susceptibilities of seven inbred strains of mice to qualified applications of 3, 4-benzpyrene. Proc Am Assoc Cancer Res. 1958;2:335
    • Latest
      J:266163 Seo GY, et al., LIGHT-HVEM Signaling in Innate Lymphoid Cell Subsets Protects Against Enteric Bacterial Infection. Cell Host Microbe. 2018 Aug 8;24(2):249-260.e4

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory