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Ahr
Gene Detail
Symbol

Name
ID
Ahr
aryl-hydrocarbon receptor
MGI:105043
Synonyms
Ah, Ahh, Ahre, bHLHe76, dioxin receptor, In
Feature Type
protein coding gene
Genetic Map
Chromosome 12
15.78 cM
Detailed Genetic Map ± 1 cM


Mapping data(36)
Sequence Map
Chr12:35497974-35535038 bp, - strand
From VEGA annotation of GRCm38

  37065 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1224  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ahr

Human
homologs
Human Homolog AHR, aryl hydrocarbon receptor
NCBI Gene ID 196
neXtProt AC  NX_P35869
Human Synonyms  bHLHe76
Human Chr (Location)  7p15; chr7:17298652-17346151 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for null or hypomorphic alleles do not respond to cyclic compounds (e.g., dioxin) and are resistant to their teratogenic effects. Depending on the allele, null mutants may also have liver defects, impaired female fertility, neonatal or postnatal lethality, and spleen abnormalities.
 
Phenotype Images(8)
Interactions
Ahr interacts with 380 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (104 annotations)
Process B-1 B cell homeostasis, B cell differentiation, ...
Component aryl hydrocarbon receptor complex, cytoplasm, ...
Function aryl hydrocarbon receptor activity, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (194)    Tissues (125)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 171
RT-PCR 23
cDNA source data(71)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(88) Genomic(10) cDNA(71) Primer pair(5) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000036999 (Evidence)
Ensembl Gene ModelENSMUSG00000019256 (Evidence)
Entrez Gene11622 (Evidence)
UniGene341377
DFCITC1602896, TC1618782, TC1740581
DoTSDT.101125370, DT.101135033, DT.101353216, DT.94402283
NIA Mouse Gene IndexU013861
PDB4M4X
Consensus CDS ProjectCCDS36434.1
International Mouse Knockout Project StatusAhr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036999 VEGA Gene Model | MGI Sequence Detail 37065 C57BL/6J ±  kb
transcript OTTMUST00000095140 VEGA | MGI Sequence Detail 5548 Not Applicable 
polypeptide OTTMUSP00000053052 VEGA | MGI Sequence Detail 805 Not Applicable 

For the selected sequences
All sequences(83) RefSeq(2) UniProt(14)
Polymorphisms
PCR(1) : SNPs within 2kb(622 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR001610 PAC motif
InterPro IPR000014 PAS domain
InterPro IPR013767 PAS fold
InterPro IPR013655 PAS fold-3
Protein Ontology PR:000003858 aryl hydrocarbon receptor
References
(Earliest) J:84245 Poel WE, et al., Comparative susceptibilities of seven inbred strains of mice to qualified applications of 3, 4-benzpyrene. Proc Am Assoc Cancer Res. 1958;2:335
(Latest) J:211686 Borland MG, et al., Modulation of aryl hydrocarbon receptor (AHR)-dependent signaling by peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) in keratinocytes. Carcinogenesis. 2014 Jul;35(7):1602-12
All references(375)
Other
accession IDs
MGD-MRK-11402, MGD-MRK-1198, MGD-MRK-1219, MGD-MRK-32082, MGI:895073

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory