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Aga
Gene Detail
Symbol

Name
ID
Aga
aspartylglucosaminidase
MGI:104873
Feature Type
protein coding gene
Genetic Map
Chromosome 8
29.13 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:53511702-53523421 bp, + strand
From Ensembl annotation of GRCm38

  11720 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:13  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AGA
Protein SuperFamily: N4-(beta-N-acetylglucosaminyl)-L-asparaginase
Gene Tree: Aga

Human
homologs
AGA, aspartylglucosaminidase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 175
neXtProt AC: NX_P20933

Human Synonyms: AGU, ASRG, GA

Human Chr (Location): 4q34.3; chr4:177430774-177442503 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human AGA

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
 
Mice homozygous for targeted mutations that inactivate this gene die prematurely and share most of the clinical, biochemical and histopathological characteristics of human aspartylglycosaminuria.
 
Human Diseases Modeled in Mice Using Aga (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Aga interacts with 33 markers (Mir29a, Mir29b-1, Mir29b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process protein deglycosylation, protein maturation, ...
Component endoplasmic reticulum, extracellular exosome, ...
Function hydrolase activity, N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(41)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase aga ; ZFIN aga    NEW 
Molecular
reagents
All nucleic(47) Genomic(5) cDNA(41) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000031521 (Evidence)
Entrez Gene 11593 (Evidence)
UniGene 334535
DFCI TC1629389, TC1641131, TC1721657
DoTS DT.101139146, DT.101169851, DT.97396485
NIA Mouse Gene Index U009340
EC 3.5.1.26
Consensus CDS Project CCDS22304.1
International Mouse Phenotyping Consortium Status Aga
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031521 Ensembl Gene Model | MGI Sequence Detail 11720 C57BL/6J ±  kb
transcript ENSMUST00000033920 Ensembl | MGI Sequence Detail 1289 Not Applicable 
polypeptide ENSMUSP00000033920 Ensembl | MGI Sequence Detail 346 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(7) UniProt(3)
Polymorphisms
SNPs within 2kb(181 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR029055 Nucleophile aminohydrolases, N-terminal
InterPro IPR000246 Peptidase T2, asparaginase 2
Protein Ontology PR:000003812 N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
References
(Earliest) J:39557 Makino M, et al., Enzymatic cleavage of glycopeptides. Biochem Biophys Res Commun. 1966 Sep 22;24(6):961-6
(Latest) J:112542 Kelo E, et al., Massive accumulation of Man2GlcNAc2-Asn in nonneuronal tissues of glycosylasparaginase-deficient mice and its removal by enzyme replacement therapy. Glycobiology. 2005 Jan;15(1):79-85
All references(35)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-28172, MGI:2142754

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory