Aga
Gene Detail

Symbol Name ID

Aga aspartylglucosaminidase MGI:104873

Feature Type

protein coding gene

Genetic Map

Chromosome 8

29.13 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr8:53511702-53523421 bp, + strand From Ensembl annotation of GRCm38   11720 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:13  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: N4-(beta-N-acetylglucosaminyl)-L-asparaginase
Gene Tree: Aga

Human homologs

Human Homolog		AGA, aspartylglucosaminidase
NCBI Gene ID		175
neXtProt AC		NX_P20933
Human Synonyms		AGU, ASRG, GA
Human Chr (Location)		4q34.3; chr4:178351928-178363657 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human AGA

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for targeted mutations that inactivate this gene die prematurely and share most of the clinical, biochemical and histopathological characteristics of human aspartylglycosaminuria.

 
Human Diseases Modeled Using Mouse Aga (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	protein deglycosylation, protein maturation, ...
Component	endoplasmic reticulum, lysosome
Function	hydrolase activity, N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (1)
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(42)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(48) Genomic(5) cDNA(42) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000031521 (Evidence)
Entrez Gene	11593 (Evidence)
UniGene	334535
DFCI	TC1629389, TC1641131, TC1721657
DoTS	DT.101139146, DT.101169851, DT.97396485
NIA Mouse Gene Index	U009340
EC	3.5.1.26
Consensus CDS Project	CCDS22304.1
International Mouse Knockout Project Status	Aga

Sequences

Length	Strain/Species
genomic	ENSMUSG00000031521	Ensembl Gene Model | MGI Sequence Detail	11720	C57BL/6J
transcript	ENSMUST00000033920	Ensembl | MGI Sequence Detail	1289	Not Applicable
polypeptide	ENSMUSP00000033920	Ensembl | MGI Sequence Detail	346	Not Applicable

All sequences(34) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(110 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000246	Peptidase T2, asparaginase 2
Protein Ontology	PR:000003812	N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase

References

(Earliest) J:39557 Makino M, et al., Enzymatic cleavage of glycopeptides. Biochem Biophys Res Commun. 1966 Sep 22;24(6):961-6
(Latest) J:112542 Kelo E, et al., Massive accumulation of Man2GlcNAc2-Asn in nonneuronal tissues of glycosylasparaginase-deficient mice and its removal by enzyme replacement therapy. Glycobiology. 2005 Jan;15(1):79-85
All references(36)

Other accession IDs

MGD-MRK-28172, MGI:2142754