Itga9
Gene Detail

Symbol Name ID

Itga9 integrin alpha 9 MGI:104756

Synonyms

2610002H11Rik, 6720458D17Rik, D9Ertd428e

Feature Type

protein coding gene

Genetic Map

Chromosome 9

70.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr9:118606690-118901003 bp, + strand From VEGA annotation of GRCm38   294314 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1664  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: integrin alpha, VLA protein type
Gene Tree: Itga9

Human homologs

Human Homolog		ITGA9, integrin, alpha 9
NCBI Gene ID		3680
neXtProt AC		NX_Q13797
Human Synonyms		ALPHA-RLC, ITGA4L, RLC
Human Chr (Location)		3p21.3; chr3:37493813-37861281 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(14) : Targeted(5) Gene trapped(9)
 

Homozygous mutation of this gene results in respiratory distress leading to postnatal lethality caused by an accumulation of pleural fluid rich in triglyceride, cholesterol and lymphocytes. Mice develop edema and lymphocytic infiltration in the chest wall.

 
Human Diseases Modeled Using Mouse Itga9 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	cell adhesion, integrin-mediated signaling pathway, ...
Component	alpha9-beta1 integrin complex, basal plasma membrane, ...
Function	collagen binding, laminin binding

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (259)    Tissues (157)    Images (46)
Theiler Stages: 17, 20, 21, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	108
RNA in situ	150
Western blot	1

cDNA source data(82)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(83) cDNA(82) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000033312 (Evidence)
Ensembl Gene Model	ENSMUSG00000039115 (Evidence)
Entrez Gene	104099 (Evidence)
UniGene	335520
DFCI	TC1577056, TC1613000, TC1620274
DoTS	DT.101376300, DT.481198
NIA Mouse Gene Index	U043032, U078604
Consensus CDS Project	CCDS23604.1, CCDS52961.1
International Mouse Knockout Project Status	Itga9

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033312	VEGA Gene Model | MGI Sequence Detail	294314	C57BL/6J
transcript	OTTMUST00000083586	VEGA | MGI Sequence Detail	7020	Not Applicable
polypeptide	OTTMUSP00000044948	VEGA | MGI Sequence Detail	1036	Not Applicable

All sequences(55) RefSeq(4) UniProt(8)

Polymorphisms

SNPs(2057 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013649	Integrin alpha-2
InterPro	IPR013519	Integrin alpha beta-propellor
InterPro	IPR000413	Integrin alpha chain
InterPro	IPR018184	Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Protein Ontology	PR:000009134	integrin alpha-9

References

(Earliest) J:15817 Palmer EL, et al., Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle [published erratum appears in J Cell Biol 1994 Feb;124(3):395]. J Cell Biol. 1993 Dec;123(5):1289-97
(Latest) J:195350 Chaen T, et al., Estrogen-dependent uterine secretion of osteopontin activates blastocyst adhesion competence. PLoS One. 2012;7(11):e48933
All references(67)

Other accession IDs

MGD-MRK-28047, MGI:1196244, MGI:1917357, MGI:2143064