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Itga9
Gene Detail
 Symbol
Name
ID
Itga9
integrin alpha 9
MGI:104756
Synonyms 2610002H11Rik, 6720458D17Rik, D9Ertd428e
Feature Type protein coding gene
Genetic Map
Chromosome 9
70.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:118606690-118901003 bp, + strand
From VEGA annotation of GRCm38

  294314 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1664  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: integrin alpha, VLA protein type
Gene Tree: Itga9

Human
homologs
Human Homolog ITGA9, integrin, alpha 9
NCBI Gene ID 3680
neXtProt AC  NX_Q13797
Human Synonyms  ALPHA-RLC, ITGA4L, RLC
Human Chr (Location)  3p21.3; chr3:37452322-37819790 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(9) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in respiratory distress leading to postnatal lethality caused by an accumulation of pleural fluid rich in triglyceride, cholesterol and lymphocytes. Mice develop edema and lymphocytic infiltration in the chest wall.
 
Human Diseases Modeled Using Mouse Itga9 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Itga9 interacts with 372 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process cell adhesion, integrin-mediated signaling pathway, ...
Component basal plasma membrane, integral component of membrane, ...
Function collagen binding, laminin binding
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (259)    Tissues (156)    Images (46)
Theiler Stages: 17, 20, 21, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 108
RNA in situ 150
Western blot 1
cDNA source data(86)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(87) cDNA(86) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000033312 (Evidence)
Ensembl Gene ModelENSMUSG00000039115 (Evidence)
Entrez Gene104099 (Evidence)
UniGene335520
DFCITC1577056, TC1613000, TC1620274
DoTSDT.101376300, DT.481198
NIA Mouse Gene IndexU043032, U078604
Consensus CDS ProjectCCDS23604.1, CCDS52961.1
International Mouse Knockout Project StatusItga9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033312 VEGA Gene Model | MGI Sequence Detail 294314 C57BL/6J ±  kb
transcript OTTMUST00000083586 VEGA | MGI Sequence Detail 7020 Not Applicable 
polypeptide OTTMUSP00000044948 VEGA | MGI Sequence Detail 1036 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(6) UniProt(8)
Polymorphisms SNPs within 2kb(2535 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013649 Integrin alpha-2
InterPro IPR013519 Integrin alpha beta-propellor
InterPro IPR000413 Integrin alpha chain
InterPro IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Protein Ontology PR:000009134 integrin alpha-9
References (Earliest) J:15817 Palmer EL, et al., Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle [published erratum appears in J Cell Biol 1994 Feb;124(3):395]. J Cell Biol. 1993 Dec;123(5):1289-97
(Latest) J:209628 Brouillard P, et al., Genetics of lymphatic anomalies. J Clin Invest. 2014 Mar 3;124(3):898-904
All references(71)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-28047, MGI:1196244, MGI:1917357, MGI:2143064

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory