About   Help   FAQ
Wars
Gene Detail
Symbol

Name
ID
Wars
tryptophanyl-tRNA synthetase
MGI:104630
Feature Type
protein coding gene
Genetic Map
Chromosome 12
59.66 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:108860030-108894174 bp, - strand
From VEGA annotation of GRCm38

  34145 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3084  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: WARS
Protein SuperFamily: tryptophan-tRNA ligase
Gene Tree: Wars

Human
homologs
WARS, tryptophanyl-tRNA synthetase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7453
neXtProt AC: NX_P23381

Human Synonyms: GAMMA-2, IFI53, IFP53

Human Chr (Location): 14q32.31; chr14:100333788-100376343 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(7) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Wars interacts with 276 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process angiogenesis, regulation of angiogenesis, ...
Component cytoplasm, extracellular exosome, ...
Function aminoacyl-tRNA ligase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (123)    Tissues (123)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 123
cDNA source data(209)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase wars ; ZFIN wars    NEW 
Molecular
reagents
All nucleic(212) cDNA(210) Primer pair(2)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000034952 (Evidence)
Ensembl Gene Model ENSMUSG00000021266 (Evidence)
Entrez Gene 22375 (Evidence)
UniGene 38433
DFCI TC1573373, TC1588780, TC1705809
DoTS DT.101386238, DT.110910058, DT.110910180, DT.111110084, DT.535039, DT.91406696, DT.97373608, DT.97414964, DT.97414968
NIA Mouse Gene Index U034345
EC 6.1.1.2
Consensus CDS Project CCDS26166.1, CCDS49171.1
International Mouse Phenotyping Consortium Status Wars
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034952 VEGA Gene Model | MGI Sequence Detail 34145 C57BL/6J ±  kb
transcript OTTMUST00000088865 VEGA | MGI Sequence Detail 1824 Not Applicable 
polypeptide OTTMUSP00000048496 VEGA | MGI Sequence Detail 481 Not Applicable 

For the selected sequences
All sequences(147) RefSeq(8) UniProt(6)
Polymorphisms
SNPs within 2kb(317 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002305 Aminoacyl-tRNA synthetase, class Ic
InterPro IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
InterPro IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
InterPro IPR009068 S15/NS1, RNA-binding
InterPro IPR002306 Tryptophan-tRNA ligase
InterPro IPR000738 WHEP-TRS domain
Protein Ontology PR:000017369 tryptophan--tRNA ligase, cytoplasmic
References
(Earliest) J:20958 Pajot B, et al., An alternative splicing modifies the C-terminal end of tryptophanyl-tRNA synthetase in murine embryonic stem cells. J Mol Biol. 1994 Sep 30;242(4):599-603
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(38)
Other
accession IDs
MGD-MRK-26067

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory