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Gcdh
Gene Detail
Symbol

Name
ID
Gcdh
glutaryl-Coenzyme A dehydrogenase
MGI:104541
Synonyms
D17825
Feature Type
protein coding gene
Genetic Map
Chromosome 8
41.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr8:84886393-84893921 bp, - strand
From VEGA annotation of GRCm38

  7529 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:130  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: GCDH
Gene Tree: Gcdh

Human
homologs
GCDH, glutaryl-CoA dehydrogenase
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2639
neXtProt AC: NX_Q92947

Human Synonyms: ACAD5, GCD

Human Chr (Location): 19p13.2; chr19:12891129-12914630 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GCDH

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit a mild motor deficit associated with a diffuse spongiform myelinopathy and elevated levels of glutaric acid and 3-hydroxyglutaric acid.
 
Interactions
Gcdh interacts with 122 markers (Mir25, Mir31, Mir34a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (46)    Tissues (45)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 46
cDNA source data(80)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gcdh ; ZFIN gcdha, gcdhb    NEW 
Molecular
reagents
All nucleic(87) Genomic(5) cDNA(80) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000030024 (Evidence)
Ensembl Gene Model ENSMUSG00000003809 (Evidence)
Entrez Gene 270076 (Evidence)
UniGene 2475
DFCI TC1577178, TC1694433, TC1685451, TC1665435
DoTS DT.101244370, DT.101337523, DT.110852758, DT.94358465, DT.94358457
NIA Mouse Gene Index U030042
EC 1.3.8.6
Consensus CDS Project CCDS22482.2
International Mouse Phenotyping Consortium Status Gcdh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030024 VEGA Gene Model | MGI Sequence Detail 7529 C57BL/6J ±  kb
transcript OTTMUST00000074438 VEGA | MGI Sequence Detail 2167 Not Applicable 
polypeptide OTTMUSP00000038755 VEGA | MGI Sequence Detail 447 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(4) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(77 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006089 Acyl-CoA dehydrogenase, conserved site
InterPro IPR009100 Acyl-CoA dehydrogenase/oxidase
InterPro IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
InterPro IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
InterPro IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
Protein Ontology PR:000007888 glutaryl-CoA dehydrogenase, mitochondrial
References
(Earliest) J:28406 Koeller DM, et al., Cloning, structure, and chromosome localization of the mouse glutaryl-CoA dehydrogenase gene. Genomics. 1995 Aug 10;28(3):508-12
(Latest) J:214705 Lagranha VL, et al., Increased glutamate receptor and transporter expression in the cerebral cortex and striatum of gcdh-/- mice: possible implications for the neuropathology of glutaric acidemia type I. PLoS One. 2014;9(3):e90477
All references(51)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-25973, MGI:2142490, MGI:2142887

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory