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Cryba2
Gene Detail
 Symbol
Name
ID
Cryba2
crystallin, beta A2
MGI:104336
Synonyms E130107M19Rik
Feature Type protein coding gene
Genetic Map
Chromosome 1
38.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:74889934-74893143 bp, - strand
From VEGA annotation of GRCm38

  3210 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10991  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: beta/gamma crystallins
Gene Tree: Cryba2

Human
homologs
Human Homolog CRYBA2, crystallin, beta A2
NCBI Gene ID 1412
neXtProt AC  NX_P53672
Human Chr (Location)  2q35; chr2:218990190-218993405 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice heterozygous or homozygous for an ENU-induced allele exhibit small lens and cataracts.
 
Interactions
Cryba2 interacts with 10 markers (Mir10b, Mir27b, Mir137, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Process lens development in camera-type eye
Function protein homodimerization activity, structural constituent of eye lens
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (46)    Tissues (14)    Images (19)
Theiler Stages: 19, 21, 22, 23, 25, 26, 28
Assay TypeResults
RNA in situ 22
RT-PCR 24
cDNA source data(35)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) Genomic(2) cDNA(35) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000020843 (Evidence)
Ensembl Gene ModelENSMUSG00000006546 (Evidence)
Entrez Gene12958 (Evidence)
UniGene86656
DFCITC1581501
DoTSDT.99747299
NIA Mouse Gene IndexU021484
Consensus CDS ProjectCCDS15059.1
International Mouse Knockout Project StatusCryba2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020843 VEGA Gene Model | MGI Sequence Detail 3210 C57BL/6J ±  kb
transcript OTTMUST00000049279 VEGA | MGI Sequence Detail 720 Not Applicable 
polypeptide OTTMUSP00000022808 VEGA | MGI Sequence Detail 197 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(12) UniProt(1)
Polymorphisms RFLP(2) : SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001064 Beta/gamma crystallin
InterPro IPR011024 Gamma-crystallin-related
Protein Ontology PR:000005909 beta-crystallin A2
References (Earliest) J:23156 Hulsebos TJ, et al., The beta crystallin genes on human chromosome 22 define a new region of homology with mouse chromosome 5. Genomics. 1995 Jan 20;25(2):574-6
(Latest) J:193107 Jin C, et al., Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesis. Dev Biol. 2013 Feb 1;374(1):96-107
All references(40)
Other
accession IDs
MGD-MRK-25664, MGI:1925115

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory