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Cryba2 Gene Detail
Summary
  • Symbol
    Cryba2
  • Name
    crystallin, beta A2
  • Synonyms
    E130107M19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:104336
    NCBI Gene: 12958
Location & Maps
more
  • Sequence Map
    Chr1:74889934-74893143 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3210 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 38.54 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CRYBA2, crystallin beta A2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CRYBA2, crystallin beta A2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CTRCT42
  • Links
    NCBI Gene ID: 1412
    neXtProt AC: NX_P53672

  • Chr Location
    2q35; chr2:218990190-218993556 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CRYBA2 associations

Human Disease Mouse Models
       Cataract 42; CTRCT42   OMIM: 115900
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    4
  • Genomic Mutations
    3 involving Cryba2
  • Incidental Mutations
Mice heterozygous or homozygous for an ENU-induced allele exhibit small lens and cataracts.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020843 VEGA Gene Model | MGI Sequence Detail 3210 C57BL/6J ±  kb
transcript OTTMUST00000049279 VEGA | MGI Sequence Detail 720 Not Applicable  
polypeptide OTTMUSP00000022808 VEGA | MGI Sequence Detail 197 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    59 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 39
    Genomic 2
    cDNA 35
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-25664, MGI:1925115
References
more
  • Summaries
    All 34
    Developmental Gene Expression 9
    Gene Ontology 2
    Phenotypes 13
  • Earliest
    J:23156 Hulsebos TJ, et al., The beta crystallin genes on human chromosome 22 define a new region of homology with mouse chromosome 5. Genomics. 1995 Jan 20;25(2):574-6
  • Latest
    J:193107 Jin C, et al., Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesis. Dev Biol. 2013 Feb 1;374(1):96-107

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory