F10
Gene Detail

Symbol Name ID

F10 coagulation factor X MGI:103107

Synonyms

AI194738, Cf10, fX

Feature Type

protein coding gene

Genetic Map

Chromosome 8

5.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr8:13037308-13056676 bp, + strand From VEGA annotation of GRCm38   19369 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:30976  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: coagulation factor X
Gene Tree: F10

Human homologs

Human Homolog		F10, coagulation factor X
NCBI Gene ID		2159
neXtProt AC		NX_P00742
Human Synonyms		FX, FXA
Human Chr (Location)		13q34; chr13:113777113-113803843 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human F10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Most homozygous mice die from fatal bleeding events at embryonic and neonatal stages, with the remaining homozygous mice dying before weaning stages.

 
Human Diseases Modeled Using Mouse F10 (1)    Alleles Annotated to Human Diseases(3)   

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	blood coagulation, hemostasis, ...
Component	extracellular region, intracellular membrane-bounded organelle, ...
Function	calcium ion binding, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (16)    Tissues (14)    Images (1)
Theiler Stages: 11, 13, 15, 17, 19, 20, 21, 22, 23, 28

Assay Type	Results
RNA in situ	2
RT-PCR	14

cDNA source data(42)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(48) Genomic(3) cDNA(44) Primer pair(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000020614 (Evidence)
Ensembl Gene Model	ENSMUSG00000031444 (Evidence)
Entrez Gene	14058 (Evidence)
UniGene	262589
DFCI	TC1580724, TC1591908, TC1714471
DoTS	DT.489445, DT.101366437, DT.524211, DT.97385990
NIA Mouse Gene Index	U009098
EC	3.4.21.6
Consensus CDS Project	CCDS40226.1, CCDS57606.1
International Mouse Knockout Project Status	F10

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020614	VEGA Gene Model | MGI Sequence Detail	19369	C57BL/6J
transcript	OTTMUST00000048845	VEGA | MGI Sequence Detail	1903	Not Applicable
polypeptide	OTTMUSP00000022500	VEGA | MGI Sequence Detail	493	Not Applicable

All sequences(58) RefSeq(4) UniProt(9)

Polymorphisms

RFLP(2) : SNPs(266 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017857	Coagulation factor, subgroup, Gla domain
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR018097	EGF-like calcium-binding, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000152	EGF-type aspartate/asparagine hydroxylation site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR000294	Gamma-carboxyglutamic acid-rich (GLA) domain
InterPro	IPR001254	Peptidase S1
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR012224	Peptidase S1A, coagulation factor VII/IX/X/C/Z
InterPro	IPR018114	Peptidase S1, trypsin family, active site
InterPro	IPR009003	Trypsin-like cysteine/serine peptidase domain
Protein Ontology	PR:000007294	coagulation factor X

References

(Earliest) J:24375 Koizumi T, et al., Homologs of genes and anonymous loci on human chromosome 13 map to mouse chromosomes 8 and 14. Mamm Genome. 1995 Apr;6(4):263-8
(Latest) J:191951 Kurdi M, et al., Coagulation factor X interaction with macrophages through its N-glycans protects it from a rapid clearance. PLoS One. 2012;7(9):e45111
All references(41)

Other accession IDs

MGD-MRK-23971, MGI:2142475