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Klra8 Gene Detail
Summary
  • Symbol
    Klra8
  • Name
    killer cell lectin-like receptor, subfamily A, member 8
  • Synonyms
    Cmv1, Cmv-1, Ly49h, Ly49u129
  • Feature Type
    protein coding gene
  • IDs
    MGI:102968
    NCBI Gene: 16639
  • Member of
    Klra cluster
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr6:130115226-130129898 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 63.44 cM
  • Mapping Data
    24 experiments
Strain
Comparison
more
  • SNPs within 2kb
    53 from dbSNP Build 142
  • Strain Annotations
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102968
protein coding gene Chr6:130115226-130129898 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0031335
protein coding gene Chr6:128561958-128834827 (-)
AKR/J MGP_AKRJ_G0031263
protein coding gene Chr6:132060920-132332859 (-)
BALB/cJ MGP_BALBcJ_G0031342
protein coding gene Chr6:128457097-128590071 (-)
C3H/HeJ MGP_C3HHeJ_G0031065
protein coding gene Chr6:132284718-132556950 (-)
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0031184
protein coding gene Chr6:127498504-127802038 (-)
FVB/NJ no annotation
LP/J MGP_LPJ_G0031265
protein coding gene Chr6:133877403-134212091 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0031837
protein coding gene Chr6:132311267-132327025 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
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Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 4 genetic backgrounds
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Most mouse strains other than C57BL/6 and C57BL/10 lack this gene and this correlates with an increased susceptiblity to CMV infection. A congenic strain in which the CMV resistant allele from C57BL/6 mice has been introduced in the BALB/c background shows high susceptibility to malarial infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16639 NCBI Gene Model | MGI Sequence Detail 14673 C57BL/6J ±  kb
transcript NM_001101620 RefSeq | MGI Sequence Detail 1178 Not Specified  
polypeptide Q60682 UniProt | EBI | MGI Sequence Detail 266 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
less
  • All nucleic 26
    Genomic 20
    cDNA 5
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-2030, MGD-MRK-2031, MGD-MRK-23805, MGI:88429
References
more
  • Summaries
    All 87
    Gene Ontology 4
    Phenotypes 39
  • Earliest
    J:10460 Scalzo AA, et al., Cmv-1, a genetic locus that controls murine cytomegalovirus replication in the spleen. J Exp Med. 1990 May 1;171(5):1469-83
  • Latest
    J:272417 Adams NM, et al., Transcription Factor IRF8 Orchestrates the Adaptive Natural Killer Cell Response. Immunity. 2018 Jun 19;48(6):1172-1182.e6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/18/2019
MGI 6.14
The Jackson Laboratory