Ube2a
Gene Detail

Symbol Name ID

Ube2a ubiquitin-conjugating enzyme E2A MGI:102959

Synonyms

HHR6A, HR6A

Feature Type

protein coding gene

Genetic Map

Chromosome X

21.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

ChrX:36874358-36884215 bp, + strand From VEGA annotation of GRCm38   9858 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68308  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ubiquitin-conjugating enzyme E2
Gene Tree: Ube2a

Human homologs

Human Homolog		UBE2A, ubiquitin-conjugating enzyme E2A
NCBI Gene ID		7319
neXtProt AC		NX_P49459
Human Synonyms		HHR6A, MRXS30, MRXSN, RAD6A, UBC2
Human Chr (Location)		Xq24; chrX:118708499-118718381 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human UBE2A

Alleles and phenotypes

All alleles(7) : Targeted(2) Gene trapped(5)
 

Homozygous mutation of this gene results in decreased body weight. Females are infertile while males show partial prenatal lethality.

 

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	DNA repair, histone H2A ubiquitination, ...
Component	chromatin, HULC complex, ...
Function	acid-amino acid ligase activity, ATP binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (12)    Tissues (2)    Images (6)
Theiler Stages: 23

Assay Type	Results
RNA in situ	12

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(14) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000017105 (Evidence)
Ensembl Gene Model	ENSMUSG00000016308 (Evidence)
Entrez Gene	22209 (Evidence)
DFCI	TC1575060, TC1595945
DoTS	DT.534506, DT.99857699, DT.99857700
NIA Mouse Gene Index	U019784
EC	6.3.2.19
Consensus CDS Project	CCDS30064.1
International Mouse Knockout Project Status	Ube2a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017105	VEGA Gene Model | MGI Sequence Detail	9858	C57BL/6J
transcript	OTTMUST00000041426	VEGA | MGI Sequence Detail	1662	Not Applicable
polypeptide	OTTMUSP00000018586	VEGA | MGI Sequence Detail	152	Not Applicable

All sequences(33) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(2 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023313	Ubiquitin-conjugating enzyme, active site
InterPro	IPR000608	Ubiquitin-conjugating enzyme, E2
InterPro	IPR016135	Ubiquitin-conjugating enzyme/RWD-like
Protein Ontology	PR:000016965	ubiquitin-conjugating enzyme E2 A

References

(Earliest) J:12580 Koken MH, et al., Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31. Genomics. 1992 Mar;12(3):447-53
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(37)

Other accession IDs

MGD-MRK-23795