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Ube2b Gene Detail
Summary
  • Symbol
    Ube2b
  • Name
    ubiquitin-conjugating enzyme E2B
  • Synonyms
    E2-14k, HR6B, Rad6b
  • Feature Type
    protein coding gene
  • IDs
    MGI:102944
    NCBI Gene: 22210
  • Gene Overview
    MyGene.info: UBE2B
Location & Maps
more
  • Sequence Map
    Chr11:51985497-52000762 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15266 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 31.82 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    UBE2B, ubiquitin conjugating enzyme E2 B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UBE2B, ubiquitin conjugating enzyme E2 B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    E2-17kDa, HHR6B, HR6B, RAD6B, UBC2
  • Links
    NCBI Gene ID: 7320
    neXtProt AC: NX_P63146

  • Chr Location
    5q31.1; chr5:134371176-134392108 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 3 alleles in 5 genetic backgrounds
    5 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Ube2b
  • Incidental Mutations
Homozygous null mutants exhibit male sterility with failure at the stage of postmeiotic condensation of chromatin in spermatids. However, in 10-20% of males there is a nearly complete absence of all germ cell types.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005613 VEGA Gene Model | MGI Sequence Detail 15266 C57BL/6J ±  kb
transcript OTTMUST00000012489 VEGA | MGI Sequence Detail 585 Not Applicable  
polypeptide OTTMUSP00000005787 VEGA | MGI Sequence Detail 152 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    68 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000016966 ubiquitin-conjugating enzyme E2 B
  • EC
  • InterPro Domains
    IPR023313 Ubiquitin-conjugating enzyme, active site
    IPR000608 Ubiquitin-conjugating enzyme E2
    IPR016135 Ubiquitin-conjugating enzyme/RWD-like
Molecular
Reagents
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  • All nucleic 16
    Genomic 1
    cDNA 14
    Other 1

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-23778
References
more
  • Summaries
    All 53
    Developmental Gene Expression 1
    Gene Ontology 15
    Phenotypes 20
  • Earliest
    J:46870 Chau V, et al., A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein. Science. 1989 Mar 24;243(4898):1576-83
  • Latest
    J:177475 Inagaki A, et al., Meiotic functions of RAD18. J Cell Sci. 2011 Aug 15;124(Pt 16):2837-50

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory