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Ube2b Gene Detail
Summary
  • Symbol
    Ube2b
  • Name
    ubiquitin-conjugating enzyme E2B
  • Synonyms
    E2-14k, HR6B, Rad6b
  • Feature Type
    protein coding gene
  • IDs
    MGI:102944
    NCBI Gene: 22210
  • Gene Overview
    MyGene.info: UBE2B
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:51985497-52000762 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 31.82 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    68 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102944
 protein coding gene Chr11:51985138-52004145 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018279
 protein coding gene Chr11:51268581-51285039 (-)
A/J MGP_AJ_G0018248
 protein coding gene Chr11:49326817-49342011 (-)
AKR/J MGP_AKRJ_G0018218
 protein coding gene Chr11:50874529-50892068 (-)
BALB/cJ MGP_BALBcJ_G0018219
 protein coding gene Chr11:49623356-49640835 (-)
C3H/HeJ MGP_C3HHeJ_G0018030
 protein coding gene Chr11:50914904-50933118 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018669
 protein coding gene Chr11:52815612-52818801 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016321
 protein coding gene Chr11:46879693-46895346 (-)
CAST/EiJ MGP_CASTEiJ_G0017595
 protein coding gene Chr11:50913637-50934963 (-)
CBA/J MGP_CBAJ_G0018005
 protein coding gene Chr11:55298162-55318714 (-)
DBA/2J MGP_DBA2J_G0018112
 protein coding gene Chr11:49027985-49043123 (-)
FVB/NJ MGP_FVBNJ_G0018107
 protein coding gene Chr11:48751872-48767098 (-)
LP/J MGP_LPJ_G0018188
 protein coding gene Chr11:51678438-51693614 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018130
 protein coding gene Chr11:56689716-56706733 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018712
 protein coding gene Chr11:50977292-50995542 (-)
PWK/PhJ MGP_PWKPhJ_G0017370
 protein coding gene Chr11:49562056-49580886 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017165
 protein coding gene Chr11:50713586-50728222 (-)
WSB/EiJ MGP_WSBEiJ_G0017642
 protein coding gene Chr11:50630278-50645127 (-)



Homology
more
  • Human Ortholog
    UBE2B, ubiquitin conjugating enzyme E2 B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UBE2B, ubiquitin conjugating enzyme E2 B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    E2-17kDa, HHR6B, HR6B, RAD6B, UBC2
  • Links
    NCBI Gene ID: 7320
    neXtProt AC: NX_P63146
    UniProt: P63146

  • Chr Location
    5q31.1; chr5:134371176-134392108 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 3 alleles in 5 genetic backgrounds
    5 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit male sterility with failure at the stage of postmeiotic condensation of chromatin in spermatids. However, in 10-20% of males there is a nearly complete absence of all germ cell types.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
    2
  • Tissues
    1
  • cDNA Data
    15
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020390 Ensembl Gene Model | MGI Sequence Detail 15266 C57BL/6J ±  kb
    transcript ENSMUST00000020657 Ensembl | MGI Sequence Detail 1792 Not Applicable  
    polypeptide ENSMUSP00000020657 Ensembl | MGI Sequence Detail 152 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 1
      cDNA 17
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-23778
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 2
      Gene Ontology 15
      Phenotypes 22
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:280284 Guo Z, et al., RAD6B Plays a Critical Role in Neuronal DNA Damage Response to Resist Neurodegeneration. Front Cell Neurosci. 2019;13:392
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    02/18/2020
    MGI 6.14     		The Jackson Laboratory