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Ube2b Gene Detail
Summary
  • Symbol
    Ube2b
  • Name
    ubiquitin-conjugating enzyme E2B
  • Synonyms
    E2-14k, HR6B, Rad6b
  • Feature Type
    protein coding gene
  • IDs
    MGI:102944
    NCBI Gene: 22210
  • Gene Overview
    MyGene.info: UBE2B
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:51985497-52000762 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15266 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 31.82 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    UBE2B, ubiquitin conjugating enzyme E2 B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UBE2B, ubiquitin conjugating enzyme E2 B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    E2-17kDa, HHR6B, HR6B, RAD6B, UBC2
  • Links
    NCBI Gene ID: 7320
    neXtProt AC: NX_P63146
    UniProt: P63146

  • Chr Location
    5q31.1; chr5:134371176-134392108 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 3 alleles in 5 genetic backgrounds
    5 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit male sterility with failure at the stage of postmeiotic condensation of chromatin in spermatids. However, in 10-20% of males there is a nearly complete absence of all germ cell types.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000005613 VEGA Gene Model | MGI Sequence Detail 15266 C57BL/6J ±  kb
    transcript OTTMUST00000012488 VEGA | MGI Sequence Detail 1792 Not Applicable  
    polypeptide OTTMUSP00000005786 VEGA | MGI Sequence Detail 152 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      68 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 1
      cDNA 17
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-23778
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 2
      Gene Ontology 16
      Phenotypes 21
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:256883 Zhou J, et al., Conserved expression of ultra-conserved noncoding RNA in mammalian nervous system. Biochim Biophys Acta. 2017 Dec;1860(12):1159-1168

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory