Ube2b Gene Detail

Summary

• Symbol
  Ube2b
• Name
  ubiquitin-conjugating enzyme E2B
• Synonyms
  E2-14k, HR6B, Rad6b

• Feature Type
  protein coding gene
• IDs
  MGI:102944
  NCBI Gene: 22210
• Gene Overview
  MyGene.info: UBE2B

Location & Maps

• Sequence Map
  Chr11:51985497-52000762 bp, - strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    15266 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 11, 31.82 cM
• Mapping Data
  2 experiments

Homology

• Human Ortholog
  UBE2B, ubiquitin conjugating enzyme E2 B

• Vertebrate Orthologs
  10

• Human Ortholog
  UBE2B, ubiquitin conjugating enzyme E2 B
  Orthology source: HomoloGene, HGNC
• Synonyms
  E2-17kDa, HHR6B, HR6B, RAD6B, UBC2
• Links
  HGNC:12473

  NCBI Gene ID: 7320

  neXtProt AC: NX_P63146

  
  
• Chr Location
  5q31.1; chr5:134371176-134392108 (+)  GRCh38.p2

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• HomoloGene
  Vertebrate Homology Class 101298
  1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  
• HCOP
  human homology predictions: UBE2B
• Protein SuperFamily
  ubiquitin-conjugating enzyme E2
• Gene Tree
  Ube2b
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  22 phenotypes from 3 alleles in 5 genetic backgrounds
  5 phenotypes from multigenic genotypes
  20 phenotype references
  

• All Mutations and Alleles
  5
• Chemically induced (other)
  1
• Targeted
  4
• Genomic Mutations
  1 involving Ube2b
• Incidental Mutations
  Mutagenetix , APF

Homozygous null mutants exhibit male sterility with failure at the stage of postmeiotic condensation of chromatin in spermatids. However, in 10-20% of males there is a nearly complete absence of all germ cell types.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  59
• GO References
  15

• External Resources
  FuncBase

Expression

• Assay Results
  2
• Tissues
  1
• cDNA Data
  12
• Literature Summary
  1

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
• Other Vertebrate Links
  Xenbase ube2b

Interactions

• Ube2b interacts with 266 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

Sequences &
Gene Models

• All Sequences
  47
• RefSeq
  8
• UniProt
  2
• CCDS
  CCDS24664.1

• VEGA
  OTTMUSG00000005613 (Evidence)
• Ensembl
  ENSMUSG00000020390 (Evidence)
• NCBI Gene
  22210

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000005613	VEGA Gene Model | MGI Sequence Detail	15266	C57BL/6J
transcript	OTTMUST00000012488	VEGA | MGI Sequence Detail	1792	Not Applicable
polypeptide	OTTMUSP00000005786	VEGA | MGI Sequence Detail	152	Not Applicable

Polymorphisms

• SNPs within 2kb
  68 from dbSNP Build 142

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000016966 ubiquitin-conjugating enzyme E2 B
• EC
  2.3.2.23
• InterPro Domains
  IPR023313 Ubiquitin-conjugating enzyme, active site
  IPR000608 Ubiquitin-conjugating enzyme E2
  IPR016135 Ubiquitin-conjugating enzyme/RWD-like

Molecular
Reagents

• All nucleic 16

  Genomic 1

  cDNA 14

  Other 1

  
  

  Microarray probesets 6

Other
Accession IDs

MGD-MRK-23778

References

• Summaries
  All 53

  Developmental Gene Expression 1

  Gene Ontology 15

  Phenotypes 20
• Earliest
  J:46870 Chau V, et al., A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein. Science. 1989 Mar 24;243(4898):1576-83
• Latest
  J:177475 Inagaki A, et al., Meiotic functions of RAD18. J Cell Sci. 2011 Aug 15;124(Pt 16):2837-50