Bdkrb2
Gene Detail

Symbol Name ID

Bdkrb2 bradykinin receptor, beta 2 MGI:102845

Synonyms

B2, B(2), B2R, BK2R, kinin B2

Feature Type

protein coding gene

Genetic Map

Chromosome 12

55.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr12:105563172-105593071 bp, + strand From NCBI annotation of GRCm38   29900 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:519  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: bradykinin receptor
Gene Tree: Bdkrb2

Human homologs

Human Homolog		BDKRB2, bradykinin receptor B2
NCBI Gene ID		624
neXtProt AC		NX_P30411
Human Synonyms		B2R, BK2, BK-2, BKR2, BRB2
Human Chr (Location)		14q32.1-q32.2; chr14:96671135-96710666 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(5) Gene trapped(1)
 

Homozygous null mutants are indistinguishable from normal littermates, but bradykinin response is eliminated in ileum, uterus, and cervical ganglia.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	acute inflammatory response to antigenic stimulus, arachidonic acid secretion, ...
Component	endosome, integral to membrane, ...
Function	bradykinin receptor activity, G-protein coupled receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) Genomic(10) cDNA(12) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000021070 (Evidence)
Entrez Gene	12062 (Evidence)
UniGene	390475
DFCI	TC1591564
DoTS	DT.87038645
NIA Mouse Gene Index	U014344
Consensus CDS Project	CCDS49160.1
International Mouse Knockout Project Status	Bdkrb2

Sequences

Length	Strain/Species
genomic	12062	NCBI Gene Model | MGI Sequence Detail	29900	C57BL/6J
transcript	NM_009747	RefSeq | MGI Sequence Detail	1680	Not Specified
polypeptide	P32299	UniProt | EBI | MGI Sequence Detail	392	Not Applicable

All sequences(19) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(199 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001504	B2 bradykinin receptor
InterPro	IPR000496	Bradykinin receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001172	B2 bradykinin receptor

Graphical View of Protein Domain Structure

References

(Earliest) J:16469 McIntyre P, et al., Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity [published erratum appears in Mol Pharmacol 1994 Mar;45(3):561]. Mol Pharmacol. 1993 Aug;44(2):346-55
(Latest) J:192051 Mori MA, et al., Kinin B1 receptor in adipocytes regulates glucose tolerance and predisposition to obesity. PLoS One. 2012;7(9):e44782
All references(118)

Other accession IDs

MGD-MRK-19754