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Zbtb7b Gene Detail
Summary
  • Symbol
    Zbtb7b
  • Name
    zinc finger and BTB domain containing 7B
  • Synonyms
    c-Krox, Thpok, Th-POK, Zfp67
  • Feature Type
    protein coding gene
  • IDs
    MGI:102755
    NCBI Gene: 22724
  • Gene Overview
    MyGene.info: ZBTB7B
Location & Maps
more
  • Sequence Map
    Chr3:89377644-89394776 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17133 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 39.09 cM, cytoband A1-A2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ZBTB7B, zinc finger and BTB domain containing 7B
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ZBTB7B, zinc finger and BTB domain containing 7B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    c-KROX, CKROX, hcKROX, THPOK, ZBTB15, ZFP67, ZFP-67, ZNF857B
  • Links
    NCBI Gene ID: 51043
    neXtProt AC: NX_O15156

  • Chr Location
    1q21.3; chr1:155002627-155018525 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 17 alleles in 10 genetic backgrounds
    9 phenotypes from multigenic genotypes
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    40
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    16
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    17
  • Transgenic
    3
  • Genomic Mutations
    2 involving Zbtb7b
  • Incidental Mutations
    APF , CvDC
Homozygous mutants exhibit absence of peripheral T cells of the CD4+CD8- MHC class II-restricted T helper subset due to a specific block in thymic development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021268 VEGA Gene Model | MGI Sequence Detail 17133 C57BL/6J ±  kb
transcript OTTMUST00000050430 VEGA | MGI Sequence Detail 3650 Not Applicable  
polypeptide OTTMUSP00000023529 VEGA | MGI Sequence Detail 544 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    38 from dbSNP Build 142
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000017593 zinc finger and BTB domain-containing protein 7B
  • InterPro Domains
    IPR000210 BTB/POZ domain
    IPR011333 SKP1/BTB/POZ domain
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
less
  • All nucleic 76
    cDNA 75
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-19660
References
more
  • Summaries
    All 70
    Developmental Gene Expression 5
    Gene Ontology 9
    Phenotypes 43
  • Earliest
    J:20520 Galera P, et al., c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin. Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9372-6
  • Latest
    J:223760 Lee HO, et al., Disregulated expression of the transcription factor ThPOK during T-cell development leads to high incidence of T-cell lymphomas. Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):7773-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory