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Zbtb7b Gene Detail
Summary
  • Symbol
    Zbtb7b
  • Name
    zinc finger and BTB domain containing 7B
  • Synonyms
    c-Krox, Thpok, Th-POK, Zfp67
  • Feature Type
    protein coding gene
  • IDs
    MGI:102755
    NCBI Gene: 22724
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
  • Regulated by
    Rr381 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr3:89284953-89300976 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 39.09 cM, cytoband A1-A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    232 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102755
 protein coding gene Chr3:89284951-89302083 (-)
129S1/SvImJ ENSMUSG00200037672
 protein coding gene Chr3:86140200-86156236 (-)
A/J ENSMUSG00195050683
 protein coding gene Chr3:86155218-86171256 (-)
AKR/J ENSMUSG00220048484
 protein coding gene Chr3:86109784-86125820 (-)
BALB/cJ ENSMUSG00180046703
 protein coding gene Chr3:86237278-86253315 (-)
C3H/HeJ ENSMUSG00175043172
 protein coding gene Chr3:86087844-86103880 (-)
C57BL/6NJ ENSMUSG00215048118
 protein coding gene Chr3:86527950-86543985 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025206
 protein coding gene Chr3:82108168-82125208 (-)
CAST/EiJ ENSTCUG00005044050
 protein coding gene Chr3:85603509-85619533 (-)
CBA/J ENSMUSG00210037851
 protein coding gene Chr3:86225487-86241523 (-)
DBA/2J ENSMUSG00185046810
 protein coding gene Chr3:86325735-86341769 (-)
FVB/NJ ENSMUSG00205047552
 protein coding gene Chr3:85149454-85165490 (-)
JF1/MsJ ENSUMUG00000030021
 protein coding gene Chr3:85934228-85950230 (-)
LP/J ENSMUSG00230031841
 protein coding gene Chr3:88361509-88377544 (-)
NOD/ShiLtJ ENSMUSG00190033973
 protein coding gene Chr3:86610635-86626668 (-)
NZO/HlLtJ ENSMUSG00225007559
 protein coding gene Chr3:91116800-91132835 (-)
PWK/PhJ ENSLUMG00010044546
 protein coding gene Chr3:85976162-85992160 (-)
SPRET/EiJ ENSMSPG00010048964
 protein coding gene Chr3:86838785-86854826 (-)
WSB/EiJ ENSIUOG00005049480
 protein coding gene Chr3:86632000-86648029 (-)



Homology
more
  • Human Ortholog
    ZBTB7B, zinc finger and BTB domain containing 7B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZBTB7B, zinc finger and BTB domain containing 7B
  • Synonyms
    c-KROX, CKROX, hcKROX, THPOK, vGAF, ZBTB15, ZFP-67, ZFP67, ZNF857B
  • Links
    NCBI Gene ID: 51043
    UniProt: O15156

  • Chr Location
    1q21.3; chr1:155001750-155018525 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 17 alleles in 11 genetic backgrounds
    9 phenotypes from multigenic genotypes
    78 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit absence of peripheral T cells of the CD4+CD8- MHC class II-restricted T helper subset due to a specific block in thymic development. Homozygosity for the p.R367Q mutation leads to protection against neuroinflammation in cerebral malaria but increased susceptibility to pulmonary tuberculosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    862
  • Tissues
    94
  • cDNA Data
    78
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22724 NCBI Gene Model | MGI Sequence Detail 16024 C57BL/6J ±  kb
    transcript NM_001410679 RefSeq | MGI Sequence Detail 3815 ZRU/MplStud  
    polypeptide Q64321 UniProt | EBI | MGI Sequence Detail 544 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 81
      cDNA 78
      Primer pair 1
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-19660
    References
    more
    • Summaries
      All 137
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 17
      Phenotypes 78
    • Earliest
      J:20520 Galera P, et al., c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin. Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9372-6
    • Latest
      J:386166 Woo DH, et al., Oral KDS2010, a Monoamine Oxidase-B (MAO-B) Inhibitor, Slows the Deterioration of Motor Coordination in Genetic SCA1 Models by Inhibiting Astrocytic MAO-B-Mediated Inflammation. J Neurochem. 2025 Dec;169(12):e70302
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory