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Zbtb7b
Gene Detail
 Symbol
Name
ID
Zbtb7b
zinc finger and BTB domain containing 7B
MGI:102755
Synonyms c-Krox, Thpok, Th-POK, Zfp67
Feature Type protein coding gene
Genetic Map
Chromosome 3
39.09 cM, cytoband A1-A2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:89377644-89394776 bp, - strand
From VEGA annotation of GRCm38

  17133 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7605  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Zbtb7b

Human
homologs
Human Homolog ZBTB7B, zinc finger and BTB domain containing 7B
NCBI Gene ID 51043
neXtProt AC  NX_O15156
Human Synonyms  c-KROX, hcKROX, THPOK, ZBTB15, ZFP67, ZFP-67, ZNF857B
Human Chr (Location)  1q21.3; chr1:155002627-155018525 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(35) : Chemically induced (ENU)(1) Gene trapped(16) Spontaneous(1) Targeted(17)
Incidental mutations (data from APF )
 
Homozygous mutants exhibit absence of peripheral T cells of the CD4+CD8- MHC class II-restricted T helper subset due to a specific block in thymic development.
 
Interactions
Zbtb7b interacts with 242 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cell differentiation, multicellular organismal development, ...
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (258)    Tissues (86)    Images (29)
Theiler Stages: 2, 3, 4, 5, 17, 21, 23, 28
Assay TypeResults
RNA in situ 243
RT-PCR 15
cDNA source data(75)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(76) cDNA(75) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021268 (Evidence)
Ensembl Gene ModelENSMUSG00000028042 (Evidence)
Entrez Gene22724 (Evidence)
UniGene262184
DFCITC1577341, TC1612394, TC1761066
DoTSDT.101246791, DT.101354501, DT.101381015, DT.111058284, DT.485921, DT.91342398
NIA Mouse Gene IndexU024281
Consensus CDS ProjectCCDS17504.1
International Mouse Knockout Project StatusZbtb7b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021268 VEGA Gene Model | MGI Sequence Detail 17133 C57BL/6J ±  kb
transcript OTTMUST00000050430 VEGA | MGI Sequence Detail 3650 Not Applicable 
polypeptide OTTMUSP00000023529 VEGA | MGI Sequence Detail 544 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(16) UniProt(7)
Polymorphisms SNPs within 2kb(38 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013069 BTB/POZ
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017593 zinc finger and BTB domain-containing protein 7B
References (Earliest) J:20520 Galera P, et al., c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin. Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9372-6
(Latest) J:209977 Boucheron N, et al., CD4(+) T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2. Nat Immunol. 2014 May;15(5):439-48
All references(73)
Other
accession IDs
MGD-MRK-19660

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory