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Zbtb7b
Gene Detail
Symbol

Name
ID
Zbtb7b
zinc finger and BTB domain containing 7B
MGI:102755
Synonyms
c-Krox, Thpok, Th-POK, Zfp67
Feature Type
protein coding gene
Genetic Map
Chromosome 3
39.09 cM, cytoband A1-A2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:89377644-89394776 bp, - strand
From VEGA annotation of GRCm38

  17133 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7605  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: ZBTB7B
Gene Tree: Zbtb7b

Human
homologs
ZBTB7B, zinc finger and BTB domain containing 7B
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 51043
neXtProt AC: NX_O15156

Human Synonyms: c-KROX, CKROX, hcKROX, THPOK, ZBTB15, ZFP67, ZFP-67, ZNF857B

Human Chr (Location): 1q21.3; chr1:155002627-155018525 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(35) : Chemically induced (ENU)(1) Gene trapped(16) Spontaneous(1) Targeted(17)
Incidental mutations (data from APF , CvDC )
 
Homozygous mutants exhibit absence of peripheral T cells of the CD4+CD8- MHC class II-restricted T helper subset due to a specific block in thymic development.
 
Interactions
Zbtb7b interacts with 242 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cell differentiation, multicellular organismal development, ...
Component nucleoplasm, nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (251)    Tissues (81)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 243
RT-PCR 8
cDNA source data(75)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase zbtb7b    NEW 
Molecular
reagents
All nucleic(76) cDNA(75) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021268 (Evidence)
Ensembl Gene Model ENSMUSG00000028042 (Evidence)
Entrez Gene 22724 (Evidence)
UniGene 262184
DFCI TC1577341, TC1612394, TC1761066
DoTS DT.101246791, DT.101354501, DT.101381015, DT.111058284, DT.485921, DT.91342398
NIA Mouse Gene Index U024281
Consensus CDS Project CCDS17504.1
International Mouse Phenotyping Consortium Status Zbtb7b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021268 VEGA Gene Model | MGI Sequence Detail 17133 C57BL/6J ±  kb
transcript OTTMUST00000050430 VEGA | MGI Sequence Detail 3650 Not Applicable 
polypeptide OTTMUSP00000023529 VEGA | MGI Sequence Detail 544 Not Applicable 

For the selected sequences
All sequences(81) RefSeq(18) UniProt(7)
Polymorphisms
SNPs within 2kb(38 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000210 BTB/POZ domain
InterPro IPR011333 POZ domain
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017593 zinc finger and BTB domain-containing protein 7B
References
(Earliest) J:20520 Galera P, et al., c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin. Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9372-6
(Latest) J:220892 Vacchio MS, et al., A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4+ T cells. Nat Immunol. 2014 Oct;15(10):947-56
All references(72)
Other
accession IDs
MGD-MRK-19660

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory