About   Help   FAQ
Pou4f3 Gene Detail
Summary
  • Symbol
    Pou4f3
  • Name
    POU domain, class 4, transcription factor 3
  • Synonyms
    Brn-3.1, Brn3.1, Brn3c
  • Feature Type
    protein coding gene
  • IDs
    MGI:102523
    NCBI Gene: 18998
  • Gene Overview
    MyGene.info: POU4F3
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:42394597-42396093 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 22.58 cM, cytoband B3-E1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102523
protein coding gene Chr18:42394539-42397249 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024380
protein coding gene Chr18:41024669-41027379 (+)
A/J MGP_AJ_G0024347
protein coding gene Chr18:39611978-39614680 (+)
AKR/J MGP_AKRJ_G0024316
protein coding gene Chr18:40697588-40700304 (+)
BALB/cJ MGP_BALBcJ_G0024347
protein coding gene Chr18:39690823-39693528 (+)
C3H/HeJ MGP_C3HHeJ_G0024113
protein coding gene Chr18:40754142-40756851 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024789
protein coding gene Chr18:42491160-42493866 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022227
protein coding gene Chr18:39435408-39438115 (+)
CAST/EiJ MGP_CASTEiJ_G0023588
protein coding gene Chr18:40706740-40709428 (+)
CBA/J MGP_CBAJ_G0024083
protein coding gene Chr18:43761808-43764509 (+)
DBA/2J MGP_DBA2J_G0024213
protein coding gene Chr18:39193901-39196610 (+)
FVB/NJ MGP_FVBNJ_G0024179
protein coding gene Chr18:38830157-38832869 (+)
LP/J MGP_LPJ_G0024297
protein coding gene Chr18:41099618-41102328 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024210
protein coding gene Chr18:45013519-45016218 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024838
protein coding gene Chr18:40573306-40575998 (+)
PWK/PhJ MGP_PWKPhJ_G0023332
protein coding gene Chr18:39408602-39411313 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023137
protein coding gene Chr18:40814196-40816909 (+)
WSB/EiJ MGP_WSBEiJ_G0023651
protein coding gene Chr18:40481789-40484492 (+)



Homology
more
  • Human Ortholog
    POU4F3, POU class 4 homeobox 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    POU4F3, POU class 4 homeobox 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BRN3C, DFNA15, DFNA42, DFNA52
  • Links
    NCBI Gene ID: 5459
    neXtProt AC: NX_Q15319
    UniProt: Q15319

  • Chr Location
    5q32; chr5:146339024-146340520 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human POU4F3 associations

Human Disease Mouse Models
      
IDs
View 1 "NOT" model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    75 phenotypes from 7 alleles in 8 genetic backgrounds
    9 phenotypes from multigenic genotypes
    5 images
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Affected mice are slightly smaller than their littermates and exhibit vertical head-tossing, circling and general hyperactive behavior typical of the shaker-waltzer class of mutants.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18998 NCBI Gene Model | MGI Sequence Detail 1497 C57BL/6J ±  kb
    transcript NM_138945 RefSeq | MGI Sequence Detail 1146 C57BL/6  
    polypeptide Q63955 UniProt | EBI | MGI Sequence Detail 338 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 7
      cDNA 11
      Primer pair 1
      Other 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-1632, MGD-MRK-19367, MGI:1342649
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 38
      Diseases 1
      Gene Ontology 13
      Phenotypes 29
    • Earliest
      J:16381 Theil T, et al., Mouse Brn-3 family of POU transcription factors: a new aminoterminal domain is crucial for the oncogenic activity of Brn-3a. Nucleic Acids Res. 1993 Dec 25;21(25):5921-9
    • Latest
      J:264387 Maurer KA, et al., Integral bHLH factor regulation of cell cycle exit and RGC differentiation. Dev Dyn. 2018 May 17;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory