Pou4f3
Gene Detail

Symbol Name ID

Pou4f3 POU domain, class 4, transcription factor 3 MGI:102523

Synonyms

Brn-3.1, Brn3.1, Brn3c

Feature Type

protein coding gene

Genetic Map

Chromosome 18

22.58 cM, cytoband B3-E1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr18:42394539-42397249 bp, + strand From VEGA annotation of GRCm38   2711 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2023  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: POU domain class 4 transcription factor, Brn3 type
Gene Tree: Pou4f3

Human homologs

Human Homolog		POU4F3, POU class 4 homeobox 3
NCBI Gene ID		5459
neXtProt AC		NX_Q15319
Human Synonyms		BRN3C, DFNA15
Human Chr (Location)		5q32; chr5:145718587-145720083 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human POU4F3

Alleles and phenotypes

All alleles(8) : Targeted(7) Spontaneous(1)
 

Affected mice are slightly smaller than their littermates and exhibit vertical head-tossing, circling and general hyperactive behavior typical of the shaker-waltzer class of mutants.

 
Phenotype Images(5)

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	auditory receptor cell differentiation, axon extension, ...
Component	nucleus, transcription factor complex
Function	DNA binding, sequence-specific DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (30 records)
Data Summary: Results (145)    Tissues (78)    Images (65)
Theiler Stages: 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	39
RNA in situ	97
Northern blot	2
RT-PCR	7

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) Genomic(7) cDNA(10) Primer pair(1) Other(2)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000039884 (Evidence)
Ensembl Gene Model	ENSMUSG00000024497 (Evidence)
Entrez Gene	18998 (Evidence)
UniGene	221181
DFCI	TC1625454
DoTS	DT.101315185, DT.94174872
Consensus CDS Project	CCDS29212.1
International Mouse Knockout Project Status	Pou4f3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000039884	VEGA Gene Model | MGI Sequence Detail	2711	C57BL/6J
transcript	OTTMUST00000103646	VEGA | MGI Sequence Detail	2360	Not Applicable
polypeptide	OTTMUSP00000057928	VEGA | MGI Sequence Detail	338	Not Applicable

All sequences(16) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(1 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR010982	Lambda repressor-like, DNA-binding domain
InterPro	IPR013847	POU domain
InterPro	IPR000327	POU-specific
Protein Ontology	PR:000013043	POU domain, class 4, transcription factor 3

References

(Earliest) J:16381 Theil T, et al., Mouse Brn-3 family of POU transcription factors: a new aminoterminal domain is crucial for the oncogenic activity of Brn-3a. Nucleic Acids Res. 1993 Dec 25;21(25):5921-9
(Latest) J:191198 Kopecky BJ, et al., Correct Timing of Proliferation and Differentiation is Necessary for Normal Inner Ear Development and Auditory Hair Cell Viability. Dev Dyn. 2013 Feb;242(2):132-47
All references(73)

Other accession IDs

MGD-MRK-1632, MGD-MRK-19367, MGI:1342649