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Pou4f3
Gene Detail
Symbol

Name
ID
Pou4f3
POU domain, class 4, transcription factor 3
MGI:102523
Synonyms
Brn-3.1, Brn3.1, Brn3c
Feature Type
protein coding gene
Genetic Map
Chromosome 18
22.58 cM, cytoband B3-E1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:42394539-42397249 bp, + strand
From VEGA annotation of GRCm38

  2711 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2023  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: POU domain class 4 transcription factor, Brn3 type
Gene Tree: Pou4f3

Human
homologs
Human Homolog POU4F3, POU class 4 homeobox 3
NCBI Gene ID 5459
neXtProt AC  NX_Q15319
Human Synonyms  BRN3C, DFNA15
Human Chr (Location)  5q32; chr5:146339024-146340520 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human POU4F3
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Spontaneous(1) Targeted(7)
Incidental mutations (data from APF )
 
Affected mice are slightly smaller than their littermates and exhibit vertical head-tossing, circling and general hyperactive behavior typical of the shaker-waltzer class of mutants.
 
Phenotype Images(5)
Interactions
Pou4f3 interacts with 190 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process auditory receptor cell differentiation, axon extension, ...
Component nucleoplasm, nucleus, ...
Function DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (32 records)
Data Summary: Results (145)    Tissues (82)    Images (65)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 39
RNA in situ 97
Northern blot 2
RT-PCR 7
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(7) cDNA(10) Primer pair(1) Other(2)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000039884 (Evidence)
Ensembl Gene ModelENSMUSG00000024497 (Evidence)
Entrez Gene18998 (Evidence)
UniGene488204
DFCITC1625454
DoTSDT.101315185, DT.94174872
Consensus CDS ProjectCCDS29212.1
International Mouse Knockout Project StatusPou4f3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000039884 VEGA Gene Model | MGI Sequence Detail 2711 C57BL/6J ±  kb
transcript OTTMUST00000103646 VEGA | MGI Sequence Detail 2360 Not Applicable 
polypeptide OTTMUSP00000057928 VEGA | MGI Sequence Detail 338 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(14 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR010982 Lambda repressor-like, DNA-binding domain
InterPro IPR013847 POU domain
InterPro IPR000327 POU-specific
Protein Ontology PR:000013043 POU domain, class 4, transcription factor 3
References
(Earliest) J:16381 Theil T, et al., Mouse Brn-3 family of POU transcription factors: a new aminoterminal domain is crucial for the oncogenic activity of Brn-3a. Nucleic Acids Res. 1993 Dec 25;21(25):5921-9
(Latest) J:215487 Thompson CL, et al., A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
All references(78)
Other
accession IDs
MGD-MRK-1632, MGD-MRK-19367, MGI:1342649

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory