Adam3
Gene Detail

Symbol Name ID

Adam3 a disintegrin and metallopeptidase domain 3 (cyritestin) MGI:102518

Synonyms

ADAM3, Cyrn1, Taz83, Taz83, tMDC

Feature Type

protein coding gene

Genetic Map

Chromosome 8

13.09 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:24677225-24725852 bp, - strand From VEGA annotation of GRCm38   48628 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:69052  Vertebrate Homology Class
1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 2 dog

Gene Tree: Adam3

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for targeted mutations that inactivate the gene are male infertile, due to the inability of the sperm to bind to the zona pellucida. If the zona pellucida is removed sperm-egg membrane fusion happens as expected.

 

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	binding of sperm to zona pellucida, proteolysis, ...
Component	cell surface, extracellular region, ...
Function	hydrolase activity, metal ion binding, ...

External Resources: FuncBase

Expression

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) cDNA(16) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000035967 (Evidence)
Ensembl Gene Model	ENSMUSG00000031553 (Evidence)
Entrez Gene	11497 (Evidence)
UniGene	5168
DFCI	TC1580381, TC1594248, TC1722835
DoTS	DT.101376258, DT.102551693, DT.40163859
NIA Mouse Gene Index	U029654
Consensus CDS Project	CCDS22196.1
International Mouse Knockout Project Status	Adam3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035967	VEGA Gene Model | MGI Sequence Detail	48628	C57BL/6J
transcript	OTTMUST00000092283	VEGA | MGI Sequence Detail	2736	Not Applicable
polypeptide	OTTMUSP00000050961	VEGA | MGI Sequence Detail	822	Not Applicable

All sequences(59) RefSeq(2) UniProt(8)

Polymorphisms

RFLP(1) : SNPs(95 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006586	ADAM, cysteine-rich
InterPro	IPR001762	Blood coagulation inhibitor, Disintegrin
InterPro	IPR013111	EGF, extracellular
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR001590	Peptidase M12B, ADAM/reprolysin
InterPro	IPR002870	Peptidase M12B, propeptide

References

(Earliest) J:18471 Lemaire L, et al., Chromosomal assignment of three novel mouse genes expressed in testicular cells. Genomics. 1994 May 15;21(2):409-14
(Latest) J:185714 Yamaguchi R, et al., Mice expressing aberrant sperm-specific protein PMIS2 produce normal-looking but fertilization-incompetent spermatozoa. Mol Biol Cell. 2012 Jul;23(14):2671-9
All references(41)

Other accession IDs

MGD-MRK-19356