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Adam3
Gene Detail
Symbol

Name
ID
Adam3
a disintegrin and metallopeptidase domain 3 (cyritestin)
MGI:102518
Synonyms
ADAM3, Cyrn1, Taz83, Taz83, tMDC
Feature Type
protein coding gene
Genetic Map
Chromosome 8
13.09 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:24677225-24725852 bp, - strand
From VEGA annotation of GRCm38

  48628 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69052  Vertebrate Homology Class
1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 2 dog

HCOP human homology predictions: ADAM3A
Gene Tree: Adam3

Human
homologs
ADAM3A, ADAM metallopeptidase domain 3A (pseudogene)
Orthology source: HGNC

IDs:
NCBI Gene ID: 1587

Human Synonyms: ADAM3, CYRN1, tMDCI

Human Chr (Location): 8p11.23; chr8:39451045-39522989 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for targeted mutations that inactivate the gene are male infertile, due to the inability of the sperm to bind to the zona pellucida. If the zona pellucida is removed sperm-egg membrane fusion happens as expected.
 
Interactions
Adam3 interacts with 228 markers (Mir7-1, Mir15a, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process binding of sperm to zona pellucida, single fertilization
Component cell surface, membrane raft
Function protein binding
External Resources: FuncBase
Expression
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(16) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000035967 (Evidence)
Ensembl Gene Model ENSMUSG00000031553 (Evidence)
Entrez Gene 11497 (Evidence)
UniGene 5168
DFCI TC1722835, TC1594248, TC1580381
DoTS DT.102551693, DT.40163859, DT.101376258
NIA Mouse Gene Index U029654
Consensus CDS Project CCDS22196.1
International Mouse Phenotyping Consortium Status Adam3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035967 VEGA Gene Model | MGI Sequence Detail 48628 C57BL/6J ±  kb
transcript OTTMUST00000092283 VEGA | MGI Sequence Detail 2736 Not Applicable 
polypeptide OTTMUSP00000050961 VEGA | MGI Sequence Detail 822 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(8) UniProt(10)
Polymorphisms
RFLP(1) : SNPs within 2kb(141 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006586 ADAM, cysteine-rich
InterPro IPR001762 Blood coagulation inhibitor, Disintegrin
InterPro IPR013111 EGF, extracellular
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
InterPro IPR002870 Peptidase M12B, propeptide
References
(Earliest) J:18471 Lemaire L, et al., Chromosomal assignment of three novel mouse genes expressed in testicular cells. Genomics. 1994 May 15;21(2):409-14
(Latest) J:210341 Fujihara Y, et al., GPI-anchored protein complex, LY6K/TEX101, is required for sperm migration into the oviduct and male fertility in mice. Biol Reprod. 2014 Mar;90(3):60
All references(40)
Other
accession IDs
MGD-MRK-19356

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory