About   Help   FAQ
Adam3
Gene Detail
 Symbol
Name
ID
Adam3
a disintegrin and metallopeptidase domain 3 (cyritestin)
MGI:102518
Synonyms ADAM3, Cyrn1, Taz83, Taz83, tMDC
Feature Type protein coding gene
Genetic Map
Chromosome 8
13.09 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:24677225-24725852 bp, - strand
From VEGA annotation of GRCm38

  48628 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69052  Vertebrate Homology Class
1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 2 dog

Gene Tree: Adam3

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for targeted mutations that inactivate the gene are male infertile, due to the inability of the sperm to bind to the zona pellucida. If the zona pellucida is removed sperm-egg membrane fusion happens as expected.
 
Interactions
Adam3 interacts with 229 markers (Mir7-1, Mir15a, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process binding of sperm to zona pellucida, integrin-mediated signaling pathway, ...
Component cell surface, extracellular region, ...
Function protein binding
External Resources: FuncBase
Expression
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(16) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000035967 (Evidence)
Ensembl Gene ModelENSMUSG00000031553 (Evidence)
Entrez Gene11497 (Evidence)
UniGene5168
DFCITC1580381, TC1594248, TC1722835
DoTSDT.101376258, DT.102551693, DT.40163859
NIA Mouse Gene IndexU029654
Consensus CDS ProjectCCDS22196.1
International Mouse Knockout Project StatusAdam3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035967 VEGA Gene Model | MGI Sequence Detail 48628 C57BL/6J ±  kb
transcript OTTMUST00000092283 VEGA | MGI Sequence Detail 2736 Not Applicable 
polypeptide OTTMUSP00000050961 VEGA | MGI Sequence Detail 822 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(4) UniProt(10)
Polymorphisms RFLP(1) : SNPs within 2kb(141 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006586 ADAM, cysteine-rich
InterPro IPR001762 Blood coagulation inhibitor, Disintegrin
InterPro IPR013111 EGF, extracellular
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
InterPro IPR002870 Peptidase M12B, propeptide
References (Earliest) J:18471 Lemaire L, et al., Chromosomal assignment of three novel mouse genes expressed in testicular cells. Genomics. 1994 May 15;21(2):409-14
(Latest) J:185714 Yamaguchi R, et al., Mice expressing aberrant sperm-specific protein PMIS2 produce normal-looking but fertilization-incompetent spermatozoa. Mol Biol Cell. 2012 Jul;23(14):2671-9
All references(42)
Other
accession IDs
MGD-MRK-19356

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/23/2014
MGI 5.19
The Jackson Laboratory