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Krt13 Gene Detail
Summary
  • Symbol
    Krt13
  • Name
    keratin 13
  • Synonyms
    K13, Krt-1.13, Krt1-13
  • Feature Type
    protein coding gene
  • IDs
    MGI:101925
    NCBI Gene: 16663
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100008153-100012392 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 63.41 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    66 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101925
protein coding gene Chr11:100008153-100012392 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019141
protein coding gene Chr11:102864453-102870009 (-)
A/J MGP_AJ_G0019109
protein coding gene Chr11:98523043-98527285 (-)
AKR/J MGP_AKRJ_G0019078
protein coding gene Chr11:101567726-101571965 (-)
BALB/cJ MGP_BALBcJ_G0019083
protein coding gene Chr11:99039429-99043677 (-)
C3H/HeJ MGP_C3HHeJ_G0018892
protein coding gene Chr11:101763574-101769329 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019532
protein coding gene Chr11:106033297-106037536 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017159
protein coding gene Chr11:95977305-95981543 (-)
CAST/EiJ MGP_CASTEiJ_G0018446
protein coding gene Chr11:102746532-102750770 (-)
CBA/J MGP_CBAJ_G0018861
protein coding gene Chr11:110466820-110472492 (-)
DBA/2J MGP_DBA2J_G0018974
protein coding gene Chr11:98098173-98102412 (-)
FVB/NJ MGP_FVBNJ_G0018963
protein coding gene Chr11:97598840-97603079 (-)
LP/J MGP_LPJ_G0019042
protein coding gene Chr11:103403561-103408544 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018994
protein coding gene Chr11:110092564-110096803 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019570
protein coding gene Chr11:101945184-101949431 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0018001
protein coding gene Chr11:101645263-101649488 (-)
WSB/EiJ MGP_WSBEiJ_G0018495
protein coding gene Chr11:101912022-101916269 (-)



Homology
more
  • Human Ortholog
    KRT13, keratin 13
  • Vertebrate Orthologs
    12
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KRT13, keratin 13
  • Synonyms
    CK13, K13, WSN2
  • Links
    NCBI Gene ID: 3860
    neXtProt AC: NX_P13646
    UniProt: P13646

  • Chr Location
    17q21.2; chr17:41500981-41505705 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with Krt13 mouse models; 1 with human KRT13 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit white sponge nevus-like phenotype in several tissues including the tongue, buccal mucosa, and esophagus showing thickened epithelium, loss of keratohyalin granules, and disorganized keratin layer.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16663 NCBI Gene Model | MGI Sequence Detail 4240 C57BL/6J ±  kb
    transcript NM_010662 RefSeq | MGI Sequence Detail 1674 ZRU/MplStud  
    polypeptide P08730 UniProt | EBI | MGI Sequence Detail 437 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      Genomic 8
      cDNA 32

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11631, MGD-MRK-18756
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 19
      Diseases 1
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:22955 Knapp B, et al., Nonepidermal members of the keratin multigene family: cDNA sequences and in situ localization of the mRNAs. Nucleic Acids Res. 1986 Jan 24;14(2):751-63
    • Latest
      J:330195 Zhou Y, et al., Airway basal cells show regionally distinct potential to undergo metaplastic differentiation. Elife. 2022 Sep 30;11:e80083

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory