Targeted mutations of this locus result in increased midgestational lethality, with up to ~50% of mutants surviving to adulthood. Gene deficiency does not affect thrombin signaling in mouse platelets but markedly attenuates thrombin signaling in mouse microvascular endothelial cells.
|Process||activation of cysteine-type endopeptidase activity involved in apoptotic process, activation of MAPKK activity, ...|
|Component||caveola, cell, ...|
|Function||G-protein alpha-subunit binding, G-protein beta-subunit binding, ...|
|InterPro||IPR017452||GPCR, rhodopsin-like, 7TM|
|InterPro||IPR000276||G protein-coupled receptor, rhodopsin-like|
|Protein Ontology||PR:000001661||proteinase-activated receptor 1|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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