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F2r
Gene Detail
Symbol

Name
ID
F2r
coagulation factor II (thrombin) receptor
MGI:101802
Synonyms
Cf2r, Par1, thrombin receptor, ThrR
Feature Type
protein coding gene
Genetic Map
Chromosome 13
50.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr13:95601789-95618433 bp, - strand
From NCBI annotation of GRCm38

  16645 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1510  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: F2R
Protein SuperFamily: proteinase-activated receptor
Gene Tree: F2r

Human
homologs
F2R, coagulation factor II (thrombin) receptor
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2149
neXtProt AC: NX_P25116

Human Synonyms: CF2R, HTR, PAR1, PAR-1, TR

Human Chr (Location): 5q13; chr5:76716043-76735770 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(5) Targeted(10)
Genomic Mutations involving F2r (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Targeted mutations of this locus result in increased midgestational lethality, with up to ~50% of mutants surviving to adulthood. Gene deficiency does not affect thrombin signaling in mouse platelets but markedly attenuates thrombin signaling in mouse microvascular endothelial cells.
 
Interactions
F2r interacts with 223 markers (Mir10b, Mir16-1, Mir17, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (12 records)
Data Summary: Results (157)    Tissues (109)    Images (41)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 137
In situ reporter (knock in) 6
RT-PCR 14
cDNA source data(10)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: ZFIN f2r    NEW 
Molecular
reagents
All nucleic(21) Genomic(4) cDNA(10) Primer pair(4) Other(3)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000048376 (Evidence)
Entrez Gene 14062 (Evidence)
DFCI TC1572371
DoTS DT.110971791, DT.489079
NIA Mouse Gene Index U035056
Consensus CDS Project CCDS26701.1
International Mouse Phenotyping Consortium Status F2r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14062 NCBI Gene Model | MGI Sequence Detail 16645 C57BL/6J ±  kb
transcript NM_010169 RefSeq | MGI Sequence Detail 3296 C57BL/6 
polypeptide P30558 UniProt | EBI | MGI Sequence Detail 430 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(2)
Polymorphisms
All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR003912 Protease-activated receptor
InterPro IPR000935 Thrombin receptor
Protein Ontology PR:000001661 proteinase-activated receptor 1
Graphical View of Protein Domain Structure
References
(Earliest) J:16414 Soifer SJ, et al., Disparate temporal expression of the prothrombin and thrombin receptor genes during mouse development. Am J Pathol. 1994 Jan;144(1):60-9
(Latest) J:222109 Liang HP, et al., EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice. Blood. 2015 Apr 30;125(18):2845-54
All references(121)
Other
accession IDs
MGD-MRK-18613, MGI:2145260

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory