Cd80
Gene Detail

Symbol Name ID

Cd80 CD80 antigen MGI:101775

Synonyms

B7-1, B7.1, Cd28l, Ly53, Ly-53

Feature Type

protein coding gene

Genetic Map

Chromosome 16

26.86 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr16:38458933-38486933 bp, + strand From NCBI annotation of GRCm38   28001 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3804  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: B-lymphocyte restricted antigen B7
Gene Tree: Cd80

Human homologs

Human Homolog		CD80, CD80 molecule
NCBI Gene ID		941
neXtProt AC		NX_P33681
Human Synonyms		B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7
Human Chr (Location)		3q13.3-q21; chr3:119243140-119278481 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(23) : Targeted(3) Gene trapped(20)
 

Homozygous mutation of this gene results in a 70% reduction in the mixed lymphocyte response in LPS- and dextran sulfate-stimulated B cells.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	positive regulation of alpha-beta T cell proliferation, positive regulation of peptidyl-tyrosine phosphorylation, ...
Component	cell surface, external side of plasma membrane, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (11)    Tissues (2)    Images (10)
Theiler Stages: 23, 26

Assay Type	Results
Immunohistochemistry	1
RNA in situ	10

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(33) Genomic(12) cDNA(21)
Microarray probesets(8)

Other database links

Ensembl Gene Model	ENSMUSG00000075122 (Evidence)
Entrez Gene	12519 (Evidence)
UniGene	89474
DFCI	TC1589926, TC1607549, TC1681520
DoTS	DT.101199618, DT.101359685, DT.40158015, DT.40158016, DT.55151868
NIA Mouse Gene Index	U040808
Consensus CDS Project	CCDS28168.1
International Mouse Knockout Project Status	Cd80

Sequences

Length	Strain/Species
genomic	12519	NCBI Gene Model | MGI Sequence Detail	28001	C57BL/6J
transcript	NM_009855	RefSeq | MGI Sequence Detail	1701	Not Specified
polypeptide	Q00609	UniProt | EBI | MGI Sequence Detail	306	Not Applicable

All sequences(42) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(2) : SNPs(141 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013162	CD80-like, immunoglobulin C2-set
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR013106	Immunoglobulin V-set
Protein Ontology	PR:000001438	CD80 molecule

Graphical View of Protein Domain Structure

References

(Earliest) J:10835 Kubota H, et al., Identification and gene cloning of a new phosphatidylinositol-linked antigen expressed on mature lymphocytes. Down-regulation by lymphocyte activation. J Immunol. 1990 Dec 1;145(11):3924-31
(Latest) J:194053 Liu B, et al., Cbx4 regulates the proliferation of thymic epithelial cells and thymus function. Development. 2013 Feb;140(4):780-8
All references(231)

Other accession IDs

MGD-MRK-11996, MGD-MRK-12039, MGD-MRK-1846, MGD-MRK-18582