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Syt4
Gene Detail
Symbol

Name
ID
Syt4
synaptotagmin IV
MGI:101759
Feature Type
protein coding gene
Genetic Map
Chromosome 18
17.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr18:31437808-31447415 bp, - strand
From NCBI annotation of GRCm38

  9608 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7559  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SYT4
Protein SuperFamily: B/K protein/synaptotagmin
Gene Tree: Syt4

Human
homologs
SYT4, synaptotagmin IV
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6860
neXtProt AC: NX_Q9H2B2

Human Synonyms: HsT1192

Human Chr (Location): 18q12.3; chr18:43267892-43277650 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a targeted null mutation exhibit impairments in motor coordination, contextual fear conditioning, and social transmission of food preference.
 
Interactions
Syt4 interacts with 301 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process calcium ion-dependent exocytosis of neurotransmitter, exocytosis, ...
Component cell, cell junction, ...
Function calcium ion binding, clathrin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (100)    Tissues (92)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 98
RT-PCR 2
cDNA source data(13)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase syt4    NEW 
Molecular
reagents
All nucleic(18) cDNA(15) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000024261 (Evidence)
Entrez Gene 20983 (Evidence)
DoTS DT.101121833, DT.523959, DT.97386429
NIA Mouse Gene Index U038276
Consensus CDS Project CCDS29109.1
International Mouse Phenotyping Consortium Status Syt4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20983 NCBI Gene Model | MGI Sequence Detail 9608 C57BL/6J ±  kb
transcript NM_009308 RefSeq | MGI Sequence Detail 3901 C57BL/6 
polypeptide P40749 UniProt | EBI | MGI Sequence Detail 425 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR001565 Synaptotagmin
Protein Ontology PR:000015906 synaptotagmin-4
Graphical View of Protein Domain Structure
References
(Earliest) J:1973 Willison K, The mouse Brachyury gene and mesoderm formation. Trends Genet. 1990 Apr;6(4):104-5
(Latest) J:216294 Kumar A, et al., Analysis of Presenilin 1 and 2 interacting proteins in mouse cerebral cortex during development. Int J Dev Neurosci. 2014 Nov;38:138-46
All references(47)
Other
accession IDs
MGD-MRK-18565

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory