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Syt4
Gene Detail
 Symbol
Name
ID
Syt4
synaptotagmin IV
MGI:101759
Feature Type protein coding gene
Genetic Map
Chromosome 18
17.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr18:31437808-31447415 bp, - strand
From NCBI annotation of GRCm38

  9608 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7559  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: B/K protein/synaptotagmin
Gene Tree: Syt4

Human
homologs
Human Homolog SYT4, synaptotagmin IV
NCBI Gene ID 6860
neXtProt AC  NX_Q9H2B2
Human Synonyms  HsT1192
Human Chr (Location)  18q12.3; chr18:43267892-43277650 (-)  GRCh38
Alleles
and
phenotypes
All alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit impairments in motor coordination, contextual fear conditioning, and social transmission of food preference.
 
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process exocytosis, negative regulation of calcium ion-dependent exocytosis, ...
Component cell, cell junction, ...
Function calcium ion binding, clathrin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (100)    Tissues (92)    Images (20)
Theiler Stages: 22
Assay TypeResults
RNA in situ 98
RT-PCR 2
cDNA source data(13)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(18) cDNA(15) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000024261 (Evidence)
Entrez Gene20983 (Evidence)
DoTSDT.101121833, DT.523959, DT.97386429
NIA Mouse Gene IndexU038276
Consensus CDS ProjectCCDS29109.1
International Mouse Knockout Project StatusSyt4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20983 NCBI Gene Model | MGI Sequence Detail 9608 C57BL/6J ±  kb
transcript NM_009308 RefSeq | MGI Sequence Detail 3901 C57BL/6 
polypeptide P40749 UniProt | EBI | MGI Sequence Detail 425 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR001565 Synaptotagmin
Protein Ontology PR:000015906 synaptotagmin-4
Graphical View of Protein Domain Structure
References (Earliest) J:1973 Willison K, The mouse Brachyury gene and mesoderm formation. Trends Genet. 1990 Apr;6(4):104-5
(Latest) J:184446 Dean C, et al., Distinct subsets of Syt-IV/BDNF vesicles are sorted to axons versus dendrites and recruited to synapses by activity. J Neurosci. 2012 Apr 18;32(16):5398-413
All references(46)
Other
accession IDs
MGD-MRK-18565

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory