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Syt4 Gene Detail
Summary
  • Symbol
    Syt4
  • Name
    synaptotagmin IV
  • Feature Type
    protein coding gene
  • IDs
    MGI:101759
    NCBI Gene: 20983
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:31570861-31580459 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 17.75 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    229 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101759
 protein coding gene Chr18:31570861-31580468 (-)
129S1/SvImJ ENSMUSG00200015734
 protein coding gene Chr18:28568566-28578172 (-)
A/J ENSMUSG00195002373
 protein coding gene Chr18:28762280-28771880 (-)
AKR/J ENSMUSG00220010986
 protein coding gene Chr18:28720417-28730018 (-)
BALB/cJ ENSMUSG00180003184
 protein coding gene Chr18:29177633-29187232 (-)
C3H/HeJ ENSMUSG00175022706
 protein coding gene Chr18:28716300-28725896 (-)
C57BL/6NJ ENSMUSG00215020341
 protein coding gene Chr18:28440637-28450235 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022061
 protein coding gene Chr18:28783764-28793308 (-)
CAST/EiJ ENSTCUG00005016013
 protein coding gene Chr18:28361967-28371587 (-)
CBA/J ENSMUSG00210016046
 protein coding gene Chr18:28751536-28761134 (-)
DBA/2J ENSMUSG00185022135
 protein coding gene Chr18:28695601-28705199 (-)
FVB/NJ ENSMUSG00205015998
 protein coding gene Chr18:28429969-28439573 (-)
JF1/MsJ ENSUMUG00000019158
 protein coding gene Chr18:28812902-28822476 (-)
LP/J ENSMUSG00230042199
 protein coding gene Chr18:30756020-30765627 (-)
NOD/ShiLtJ ENSMUSG00190006493
 protein coding gene Chr18:28489813-28499411 (-)
NZO/HlLtJ ENSMUSG00225045361
 protein coding gene Chr18:30693400-30702998 (-)
PWK/PhJ ENSLUMG00010003342
 protein coding gene Chr18:28966966-28976560 (-)
SPRET/EiJ ENSMSPG00010020729
 protein coding gene Chr18:28963541-28973115 (-)
WSB/EiJ ENSIUOG00005002645
 protein coding gene Chr18:28461335-28470940 (-)



Homology
more
  • Human Ortholog
    SYT4, synaptotagmin 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SYT4, synaptotagmin 4
  • Synonyms
    HsT1192
  • Links
    NCBI Gene ID: 6860
    UniProt: Q9H2B2

  • Chr Location
    18q12.3; chr18:43267892-43277535 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit impairments in motor coordination, contextual fear conditioning, and social transmission of food preference.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    126
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    700
  • Tissues
    94
  • cDNA Data
    14
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024261 Ensembl Gene Model | MGI Sequence Detail 9599 C57BL/6J ±  kb
    transcript ENSMUST00000025110 Ensembl | MGI Sequence Detail 3892 Not Applicable  
    polypeptide ENSMUSP00000025110 Ensembl | MGI Sequence Detail 425 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 16
      Primer pair 2
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-18565
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 11
      Gene Ontology 19
      Phenotypes 20
    • Earliest
      J:1973 Willison K, The mouse Brachyury gene and mesoderm formation. Trends Genet. 1990 Apr;6(4):104-5
    • Latest
      J:371381 Higuchi K, et al., Synaptotagmin 4 Supports Spontaneous Axon Sprouting after Spinal Cord Injury. J Neurosci. 2024 Oct 23;44(43)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory