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Anks1b Gene Detail
Summary
  • Symbol
    Anks1b
  • Name
    ankyrin repeat and sterile alpha motif domain containing 1B
  • Synonyms
    AIDA-1b, C030032C09Rik, E530015N03Rik, Gm10937, LOC380650
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924781
    NCBI Gene: 77531
  • Alliance
    gene page
  • Transcription Start Sites
    41 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:89709371-90809162 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 45.28 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8682 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924781
 protein coding gene Chr10:89707238-90809162 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017641
 protein coding gene Chr10:91082397-92239883 (+)
A/J MGP_AJ_G0017620
 protein coding gene Chr10:87965512-89047512 (+)
AKR/J MGP_AKRJ_G0017578
 protein coding gene Chr10:90473227-91593631 (+)
BALB/cJ MGP_BALBcJ_G0017583
 protein coding gene Chr10:88227407-89335461 (+)
C3H/HeJ MGP_C3HHeJ_G0017406
 protein coding gene Chr10:90492043-91620751 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018040
 protein coding gene Chr10:94139509-95306643 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015722
 protein coding gene Chr10:83674226-84726424 (+)
CAST/EiJ MGP_CASTEiJ_G0016971
 protein coding gene Chr10:90408062-91544461 (+)
CBA/J MGP_CBAJ_G0017375
 protein coding gene Chr10:98012321-99233612 (+)
DBA/2J MGP_DBA2J_G0017481
 protein coding gene Chr10:87080325-88174936 (+)
FVB/NJ MGP_FVBNJ_G0017473
 protein coding gene Chr10:86309624-87395004 (+)
LP/J MGP_LPJ_G0017555
 protein coding gene Chr10:91724910-92873424 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017504
 protein coding gene Chr10:99495395-100678419 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018077
 protein coding gene Chr10:90362759-91490639 (+)
PWK/PhJ MGP_PWKPhJ_G0016752
 protein coding gene Chr10:87117892-88210566 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016540
 protein coding gene Chr10:89112882-90250693 (+)
WSB/EiJ MGP_WSBEiJ_G0017030
 protein coding gene Chr10:90342060-91465332 (+)



Homology
more
  • Human Ortholog
    ANKS1B, ankyrin repeat and sterile alpha motif domain containing 1B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANKS1B, ankyrin repeat and sterile alpha motif domain containing 1B
  • Synonyms
    AIDA, AIDA-1, ANKS2, cajalin-2, EB1, EB-1
  • Links
    NCBI Gene ID: 56899
    neXtProt AC: NX_Q7Z6G8
    UniProt: Q7Z6G8

  • Chr Location
    12q23.1; chr12:98726457-99984936 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in neurons alters hippocampal synaptic transmission.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    14
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000058589 Ensembl Gene Model | MGI Sequence Detail 1099792 C57BL/6J ±  kb
transcript ENSMUST00000183156 Ensembl | MGI Sequence Detail 4248 Not Applicable  
polypeptide ENSMUSP00000138539 Ensembl | MGI Sequence Detail 1259 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    28 Sequences
  • Protein Ontology
    PR:000004052 ankyrin repeat and sterile alpha motif domain-containing protein 1B
    (term hierarchy)
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR033635 Ankyrin repeat and SAM domain-containing protein 1/Caskin
    IPR041880 Ankyrin repeat and SAM domain-containing protein 1, SAM repeat 1
    IPR041882 Ankyrin repeat and SAM domain-containing protein 1, SAM repeat 2
    IPR036770 Ankyrin repeat-containing domain superfamily
    IPR011993 PH-like domain superfamily
    IPR006020 PTB/PI domain
    IPR001660 Sterile alpha motif domain
    IPR013761 Sterile alpha motif/pointed domain superfamily
Molecular
Reagents
less
  • All nucleic 16
    cDNA 16

    Microarray probesets 11
Other
Accession IDs
less
MGI:2686401, MGI:3779147
References
more
  • Summaries
    All 43
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 15
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:346322 Carbonell AU, et al., Comparing synaptic proteomes across five mouse models for autism reveals converging molecular similarities including deficits in oxidative phosphorylation and Rho GTPase signaling. Front Aging Neurosci. 2023;15:1152562
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory