Mapping Data

Experiment

• Experiment
  TEXT-QTL-Candidate Genes
• Chromosome
  11
• Reference
  J:91835 Kaput J, et al., Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions. Physiol Genomics. 2004 Aug 11;18(3):316-24
• ID
  MGI:3487129

Genes

Gene
Nidd4n
Dbn1
Dvl2
Nidd1n
Bwtq5
Wt10q3
Wt6q3
Nhp2
Septin8
Skp1
Mpdu1
Wg4
Bw4
Dusp14
Spag7
Derl2
Srsf1
Rara
Fasn
Grb2
Nidd4

Notes

• Experiment
  The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A^vy animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A^vy genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes.
  
  On mouse Chromosome 11, candidate genes for diabesity QTL Nidd4n (2 cM) are Dbn1 (34 cM- **Note: Location of Dbn1 is 34 cM on mouse Chromosome 13 according to mapping data in the MGI database**) and Dvl2 (36.5 cM). Both Dbn1 and Dvl2 show differential expression on the restricted and unrestricted diets on the A/A^vy background.
  
  Candidate genes for diabesity QTLs Nidd1n (31 cM), Bwtq5 (27.8 cM), Wt10q3 (32 cM), Wt6q3 (36 cM) are Nola2 (28.5 cM, formerly Nhp2), Sept8 (28.75 cM), Skp1a (31 cM), and Mpdu1 (39 cM). Skp1a and Nola2 both show differential expression between restricted and unrestricted diets on the A/A^vy background. Sept8 shows differential expression between A/a and A/A^vy animals on the restricted diet.
  
  Candidate genes for diabesity QTLs Wg4 (46 cM) and Bw4 (55 cM) are Dusp14 (48 cM), Spag7 (42 cM), Derl2 (42 cM, formerly Flana), Sfrs1 (49 cM), and Rara (57.8 cM). Dusp14, Derl2, and Spag7 all show differential expression between A/a and A/A^vy animals on the restricted diet. Sfrs1 shows differential expression between the restricted and unrestricted diets on the A/a background. Rara shows differential expression between the restricted and unrestricted diet on the A/a background as well as between A/a and A/A^vy animals on the restricted diet.
  
  Fasn (72 cM) and Grb2 (75 cM) are candidate genes for diabesity QTL Nidd4 (68 cM). Fasn shows differential expression between restricted and unrestricted diets on the A/A^vy background while Grb2 shows differential expression between A/a and A/A^vy animals on the unrestricted diet.