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Mapping Data
Experiment
  • Experiment
    TEXT-QTL
  • Chromosome
    7
  • Reference
    J:87793 Rocha JL, et al., A large-sample QTL study in mice: II. Body composition. Mamm Genome. 2004 Mar;15(2):100-13
  • ID
    MGI:3043709
Genes
GeneAlleleAssay TypeDescription
Kidq5 visible phenotype
D7Mit55 PCR amplified length variant
D7Mit91 PCR amplified length variant
Splq7 visible phenotype
Lwq19 visible phenotype
Epfq5 visible phenotype
Kidq6 visible phenotype
D7Mit105 PCR amplified length variant
Notes
  • Experiment
    Linkage analysis was performed on 552 10-week old male animals from a (M16i x L6)F2 intercross to identify QTLs associated with measurements of growth such as organ weight, growth rate, and adiposity. 63 polymorphic markers spanning the 19 autosomes wereused in the genome scan. Parental strain M16i is a long term selection line for rapid 3- and 6- week weight gain whereas parental strain L6 is a long term selection line for low 6-week body weight. A total of 50 significant QTLs (LOD>3.3) were mapped over 15 chromosomes. More than 25% of loci mapped to mouse Chromosome 2.

    On mouse Chromosome 7, QTLs for kidney weight (Kidq5, Kidq6), spleen weight (Splq7), liver weight (Lvrq6) and epididymal fat pad weight (Epfq5) were identified. Kidq5 and Kidq6 mapped to 15 cM (LOD=5.3) between D7Mit55 and D7Mit91 and to 63.5 cM (LOD=3.8) between D7Mit11 and D7Mit105, respectively. L6-derived alleles confer recessively inherited decrease in kidney weight at Kidq5 and recessively inherited increase in kidney weight at Kidq6. Splq7 maps to 16.6 cM (LOD=4.5) between D7Mit55 and D7Mit91 with L6-derived alleles conferring recessively inherited decrease in spleen weight. Lvrq6 mapped to 21.5 cM (LOD=5.0) between D7Mit55 and D7Mit91 with L6-derived alleles conferring dominantly inherited decrease in liver weight. Epfq5 mapped to 21.5 cM (LOD=3.4) between D7Mit55 and D7Mit91 with L6-derived alleles conferring dominantly inherited decrease in epididymal fat pad weight.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory