Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  17
• Reference
  J:78168 Adarichev VA, et al., Major histocompatibility complex controls susceptibility and dominant inheritance, but not the severity of the disease in mouse models of rheumatoid arthritis. Immunogenetics. 2002 Jun;54(3):184-92
• ID
  MGI:2669013

Genes

Gene	Assay Type
Pgia37	reported elsewhere
H2	reported elsewhere
D17Mit60	PCR amplified length variant
D17Mit10	PCR amplified length variant

Notes

• Experiment
  Pgia37, a QTL associated with arthritis on mouse Chromosome 17 at 23 cM, was examined in a population of (BALB/cCrl x DBA/1J)F2 animals.
  
  Parental strain BALB/cCrl is resistant to collagen-induced arthritis (CIA) and susceptible to proteoglycan-induced arthritis (PGIA) while parental strain DBA/1J is susceptible to CIA and resistant to PGIA. Surprisingly, F2 animals exhibit more severe CIA than parental DBA/1J susceptible animals.
  
  Pgia37 shows linkage to CIA susceptibility (LOD=22), severity (LOD=17),and onset (LOD=12) from 6.5 cM - 45.3 cM on chromosome 17, and shows linkage to PGIA susceptibility (LOD=4.9), severity (LOD=6.5), and onset (LOD=5) from 17.4 cM - 24.5 cM on chromosome 17.
  
  The H2 locus maps to Pgia37 and was analyzed for its association with CIA and PGIA. The H2^q allele showed correlation to CIA onset and susceptibility with a dominant mode of inheritance, while the H2^q allele showed correlation with PGIA susceptibility and onset with a codominant mode of inheritance in F2 animals.