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Mapping Data
Experiment
  • Experiment
    TEXT-QTL
  • Chromosome
    1
  • Reference
    J:66211 Dragani TA, et al., Mapping of melanoma modifier loci in RET transgenic mice. Jpn J Cancer Res. 2000 Nov;91(11):1142-7
  • ID
    MGI:1931472
Genes
GeneAlleleAssay TypeDescription
Melm1 visible phenotype
D1Mit494 PCR amplified length variant
D1Mit150 PCR amplified length variant
Cxcr4
Inhbb
Ifi201
Ifi202a
Ifi203
Ifi204
H25
Itpkb
Terf1
Traf5
Melm2 visible phenotype
Tgfb2
Notes
  • Experiment
    Line 304 is a RET transgene that was maintained in a (C57BL/6 x BALB/c)F1 background. The RET transgenic line is a model for melanoma development. A partial congenic line was developed to N3 by crossing (C57BL/6 x BALB/c)F1 transgenic carriers to C57BL/6J. Importantly these N3 congenics were heterozygous for the RET transgene. The N3 RET congenics were crossed to BALB/c and then backcrossed to the N3 RET transgenic line producing 195 backcross mice for the purpose to scan the genome for melanoma phenotypes. Two markers on mouse Chromosome 1 were associated with the early onset of melanoma. The first of these, Melm1 was associated significantly with D1Mit494 (LOD 2.5), with a second marker Melm2 significantly associated with marker D1Mit150 (LOD 4.2). Authors suggest Cxcr4 and Inhbb as candidates for Melm1 and Ifi201, Ifi202a, Ifi203, Ifi204, H25, Itpkb, Tgfb2, Terf1 and Traf5 as candidates for Melm2. Another marker, Melm3 was associated with mouse Chromosome 11.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory