Experiment
Thymectomized progeny, from a backcross of (C57BL/6J x A/J)F1 (susceptible to autoimmune ovarian dysgenesis - AOD) and C57BL/6J (resistant) mice, which exhibited autoimmune oophoritis and ovarian atrophy were subjected to linkage analysis. Using 131 microsatellite loci covering the genome, maximal linkage (P = 0.0007) of a quantitative trait locus associated with phentypic expression of atrophy was found on mouse Chromosome 3 in association with markers D3Mit224, D3Mit63, D3Mit133, D3Mit226, D3Mit182, D3Mit227, D3Mit64, D3Mit5, D3Mit6 and D3Mit65. The authors designated this locus Aod2. Maximum likelihood estimates were carried out on Chromosome 3 by multilocus linkage analysis. A 95% confidence interval was found to be bordered by D3Mit21 (Il2) and D3Mit154. The authors note the presence of Il2, Fgf2, and in particular Idd3 within this region.
Analysis Tools