Inverted Screen for Project: NIH-1304 Test Description: A motor strength deficit is apparent when there is a 50% point difference between (-/-) or (+/-) mice and (+/+) mice for the fell down response. 0/8 or 1/8 (-/-) or (+/-) mice not climbing indicates impaired motor coordination. 7/8 or 8/8(-/-) or (+/-) mice climbing up indicates enhanced motor coordination.

Results Genotype Ratio Fell Down % Ratio Climbed Up % +/+ (n=4) 0/4 0 2/4 50 +/- (n=4) 0/4 0 3/4 75 -/- (n=8) 2/8 25 3/8 38 WT Population Fell Down 3.62 Climbed Up 60.04 *Red color coding indicates a notable difference.

Inverted Screen data for Project: NIH-1304 - Results        Mouse Label Genotype Age (days) Test Result Weight at Testing Comments M-69 het 86 Climbed Up 29.2 23 Seconds. F-79 het 84 Did Not Climb 26.9 M-85 het 84 Climbed Up 35.5 24 Seconds. F-88 het 84 Climbed Up 24.0 54 Seconds. M-59 hom 86 Did Not Climb 36.2 F-70 hom 86 Climbed Up 27.1 11 Seconds. F-77 hom 84 Fell Down 23.4 7 Seconds. M-82 hom 84 Did Not Climb 31.5 45 Seconds. F-102 hom 84 Climbed Up 22.7 37 Seconds. M-106 hom 83 Climbed Up 30.6 35 Seconds. M-110 hom 83 Fell Down 31.9 4 Seconds F-117 hom 83 Did Not Climb 30.4 M-63 wt 86 Climbed Up 37.2 22 Seconds. M-89 wt 84 Climbed Up 30.0 34 Seconds. F-101 wt 84 Did Not Climb 24.0 F-121 wt 83 Did Not Climb 31.7

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Lexicon Phenotypic Analysis software version 05.05.00.05