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Test Description: The FOB is a series of situations applied to the animal to determine gross sensory and motor deficits. A subset of tests from the Irwin neurological screen that evaluates gross neurological function is used. In general, short-duration, tactile, olfactory, and visual stimuli are applied to the animal to determine their ability to detect and respond normally. These simple tests take approximately 10 minutes and the mouse is returned to its home cage at the end of testing.
Temperature Assay: Mouse body temperature was determined by gently inserting a small probe into the rectum and recording the temperature with a digital read-out. This process takes less than 5 seconds.


Results



Phenotypic differences may have been observed in the Functional Observation Battery tests.


Results data distribution (n, %) of abnormal (failed) test for project:NIH-1304

Functional Observational Battery
Test Description: The FOB is a series of situations applied to the animal to determine gross sensory and motor deficits. A subset of tests from the Irwin neurological screen that evaluates gross neurological function is used. In general, short-duration, tactile, olfactory, and visual stimuli are applied to the animal to determine their ability to detect and respond normally. These simple tests take approximately 10 minutes and the mouse is returned to its home cage at the end of testing.
BehaviorNew Category
Genotype
WildType
(WT, +/+)
Heterozygote
(Het, +/-,-/+)
Homozygote
(Hom, -/-)
n=4
n=4
n=8
"General health and Physical Condition
wt
het
hom
Whiskers Absent
1 (25%)
0 (0%)
1 (13%)
Bald_Hair_Patches Present
0 (0%)
0 (0%)
0 (0%)
Piloerection Present
0 (0%)
0 (0%)
2 (25%)
Exophthalmus Present
2 (50%)
3 (75%)
6 (75%)
Palpebral_Closure Present
0 (0%)
0 (0%)
0 (0%)
Straub_Tail Present
0 (0%)
0 (0%)
0 (0%)
Curly_Kinked_Tail Present
0 (0%)
0 (0%)
0 (0%)
Kyphosis Present
0 (0%)
0 (0%)
0 (0%)
Lordosis Present
0 (0%)
0 (0%)
0 (0%)
Spontaneous Activity
wt
het
hom
Exhibits Wild Running Behavior
0 (0%)
0 (0%)
0 (0%)
Exhibits Freezing Behavior
0 (0%)
0 (0%)
0 (0%)
Exhibits Sniffing Behavior
0 (0%)
0 (0%)
0 (0%)
Exhibits Licking Behavior
0 (0%)
0 (0%)
0 (0%)
Rearing Behavior Absent
1 (25%)
1 (25%)
3 (38%)
Exhibits Jumping Behavior
0 (0%)
0 (0%)
0 (0%)
Defication Absent
0 (0%)
1 (25%)
2 (25%)
Urination
0 (0%)
1 (25%)
1 (13%)
Does not Move All Around The Cage
0 (0%)
0 (0%)
1 (13%)
Head Bobbing Present
0 (0%)
0 (0%)
0 (0%)
Head Flicking Present
0 (0%)
0 (0%)
0 (0%)
Circling Present
0 (0%)
0 (0%)
0 (0%)
Waltzing Present
0 (0%)
0 (0%)
0 (0%)
Abnormal Gait Present
0 (0%)
0 (0%)
0 (0%)
Retropulsion Present
0 (0%)
1 (25%)
0 (0%)
Prancing Forelimbs Present
0 (0%)
0 (0%)
0 (0%)
Tail Suspension Response
wt
het
hom
20 Second Tail Suspension Response - Normal Splay of Limbs
0 (0%)
0 (0%)
0 (0%)
20 Second Tail Suspension Response - Does Not Turn Up Sides
4 (100%)
4 (100%)
8 (100%)
20 Second Tail Suspension Response - Does Not Grab ipsilateral Leg
2 (50%)
3 (75%)
4 (50%)
20 Second Tail Suspension Response - Does Not Grab Contralateral Leg
2 (50%)
3 (75%)
4 (50%)
20 Second Tail Suspension Response - Hindpaw Clutch
0 (0%)
1 (25%)
0 (0%)
20 Second Tail Suspension Response - Forepaw Clutch
1 (25%)
1 (25%)
0 (0%)
20 Second Tail Suspension Response - Other Responses
0 (0%)
1 (25%)
0 (0%)
* Blue color coding is set for a threshold of 10%
* Red color coding indicates het or hom value >= or <= 50% of the wildtype value.

Functional Observation Battery Comments:
  • F-88(het): Mouse climbed tail during 20 second tail suspension.
  • F-117(hom): Mouse climbed tail during 20 second tail suspension.





  Functional Observational Battery Tests data for Project: NIH-1304 - Results        Export Data to Spreadsheet
Mouse
Label
Genotype Age
(days)
Whiskers Bald Hair
Patches
Piloerection Exophthalmus Palpebral
Closure
Curly
Kinked Tail
Kyphosis Lordosis Wild
Running
Freezing Sniffing Licking Rearing Jumping Defecation Urination Move All
Around
Cage
Head
Bobbing
Head
Flicking
Circling Waltzing Abnormal
Gait
Retropulsion Prancing
Forelimbs
Body
Posture
Adjustment -
Normal
Splay Limbs
Body
Posture
Adjustment
Fall Over
Righting
Reflex
Whisker
Orienting
Response -
Whiskers
Stop Moving
Whisker
Orienting
Response -
Turn
Toward
Touch
Touch
Reflex - eye
Touch
Reflex - ear
Touch
Reflex -
flank
Pupil
Reflex
Visual
Reaching
Tail
Suspension
- Normal
Splay Limbs
Tail
Suspension
- Turn Up
Sides
Tail
Suspension
- Grab
ipsilateral
Leg
Tail
Suspension
- Grab
Contralateral
Leg
Tail
Suspension
- Hindpaw
Clutch
Tail
Suspension
- Forepaw
Clutch
Tail
Suspension
- Other
Responses
Catalepsy
Response
Olfactory
Response
Temperature Temperature
Value
Straub
Tail
M-69 het 89 Yes No No Yes No No No No No No Yes No Yes No Yes Yes Yes No No No No No Yes No Yes No Yes Yes No Yes Yes No Yes Yes NT Yes Yes Yes No No No Yes NT 37.9 No
F-79 het 87 Yes No No Yes No No No No No No Yes No Yes No Yes No Yes No No No No No No No Yes No Yes Yes No Yes Yes No Yes Yes NT Yes Yes Yes Yes Yes No Yes NT 37.6 No
M-85 het 87 Yes No No No No No No No No No Yes No Yes No No No Yes No No No No No No No Yes No Yes Yes No Yes Yes No Yes Yes NT Yes No No No No No Yes NT 36.8 No
F-88 het 87 Yes No No Yes No No No No No No Yes No No No Yes No Yes No No No No No No No Yes No Yes Yes No Yes Yes No Yes Yes NT Yes Yes Yes No No Yes Yes NT 38.7 No
M-59 hom 89 Yes No No Yes No No No No No No Yes No Yes No No No Yes No No No No No No No Yes No Yes Yes No Yes Yes No Yes Yes NT Yes Yes Yes No No No Yes NT 38.2 No
F-70 hom 89 Yes No No Yes No No No No No No Yes No No No Yes No Yes No No No No No No No Yes No Yes Yes No Yes Yes No Yes Yes NT Yes No No No No No Yes NT 37.5 No
F-77 hom 87 Yes No No Yes No No No No No No Yes No No No Yes No No No No No No No No No Yes No Yes Yes No Yes Yes No Yes Yes NT Yes No No No No No Yes NT 38.3 No
M-82 hom 87 Yes No Yes Yes No No No No No No Yes No Yes No No No Yes No No No No No No No Yes No Yes Yes No Yes Yes No Yes Yes NT Yes Yes Yes No No No Yes NT 38.3 No
F-102 hom 87 Yes No No Yes No No No No No No Yes No No No Yes No Yes No No No No No No No Yes No Yes Yes No Yes Yes No Yes Yes NT Yes Yes Yes No No No Yes NT 37.8 No
M-106 hom 86 Yes No Yes Yes No No No No No No Yes No Yes No Yes Yes Yes No No No No No No No Yes No Yes Yes No Yes Yes No Yes Yes NT Yes No No No No No Yes NT 39.0 No
M-110 hom 86 No No No No No No No No No No Yes No Yes No Yes No Yes No No No No No No No Yes No Yes NT NT Yes Yes No Yes No NT Yes No No No No No Yes NT 38.4 No
F-117 hom 86 Yes No No No No No No No No No Yes No Yes No Yes No Yes No No No No No No No Yes No Yes Yes No Yes Yes No Yes Yes NT Yes Yes Yes No No No Yes NT 37.8 No
M-63 wt 89 Yes No No Yes No No No No No No Yes No Yes No Yes No Yes No No No No No No No Yes No Yes Yes No Yes Yes No Yes Yes NT Yes No No No No No Yes NT 38.1 No
M-89 wt 87 No No No No No No No No No No Yes No Yes No Yes No Yes No No No No No No No Yes No Yes NT NT Yes Yes No Yes Yes NT Yes Yes Yes No No No Yes NT 37.2 No
F-101 wt 87 Yes No No Yes No No No No No No Yes No Yes No Yes No Yes No No No No No No No Yes No Yes Yes No Yes Yes No Yes Yes NT Yes No No No Yes No No NT 37.3 No
F-121 wt 86 Yes No No No No No No No No No Yes No No No Yes No Yes No No No No No No No Yes No Yes Yes No Yes Yes No Yes Yes NT Yes Yes Yes No No No Yes NT 37.9 No
 


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