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DEXA for Project: NIH-1304
Test Description: Mice were anesthetized by intraperitoneal injection of Avertin (1.25% 2,2,2,-tribromoethanol, 20 ml/kg body weight ), measured body length and weight, and then placed in a prone position on the platform of the PIXImusTM Densitometer (Lunar Inc.) for a DEXA scan. Using a Lunar PIXImus software, the Bone mineral density (BMD) and fat composition (% fat) and total tissue mass (TTM) were determined in the regions of interest (ROI, i.e., whole body, vertebrae, and both femurs).


Results

  BMD = Bone Mineral Density (g/cm2);
  BMC = Bone Mineral Content (g);
  LBM = Lean Body Mass (g);
  BMC / LBM = BMC / LBM (mg/g); 		  FAT(%) = % of Body FAT;
  FAT(g) = TTM X FAT(%)/100;
  TTM = Total Tissue Mass (g);
  vBMD = Volumetric BMD (mg/cm3)

MALE DATA




FEMALE DATA



DEXA Combined Gender Score
Parameter Score
Body BMD  97.0%
Body vBMD  94.5%
Body BMC/LBM  103.5%
Femur BMD  98.4%
Vertebral BMD  94.5%
Total Tissue Mass  92.1%
Body LBM  98.6%
Body % Fat  80.2%
Body Fat Content  73.3%
The Combined Gender Score provides the average ration of Hom to WT values combining
males and females, with a correction factor for the number of mice in each group. No score
is generated if there are fewer than 4 HOM mice or fewer than 3 WT mice


DEXA Analysis: Male
Mouse Label Genotype Whole Body Vertebrae Femurs
BMD (g/cm2) BMC (g) TTM % FAT LBM (g) BMC / LBM (mg/g) vBMD (mg/cm3) BMD (g/cm2) BMD (g/cm2)
M-63wt0.05590.598834.5722.4326.2222.8417.070.06820.08595000
M-89wt0.05860.651827.4416.1422.3629.1517.570.08290.09515000
M-69het0.05440.588726.1216.2821.2827.6716.540.07770.08410000
M-85het0.0510.48433.1124.9324.3719.8616.550.06590.07475000
M-106hom0.05250.57727.1113.2622.9425.1515.840.07310.08415000
M-110hom0.05070.555727.9413.1723.723.4415.310.07670.08485000
M-59hom0.05730.646333.4219.0826.424.4817.070.07680.09625000
M-82hom0.05330.573128.9421.4722.1525.8716.250.06120.08165000

DEXA Analysis: Female
Mouse Label Genotype Whole Body Vertebrae Femurs
BMD (g/cm2) BMC (g) TTM % FAT LBM (g) BMC / LBM (mg/g) vBMD (mg/cm3) BMD (g/cm2) BMD (g/cm2)
F-101wt0.05210.527321.5319.2816.8531.2916.390.0660.07435000
F-121wt0.05330.46828.9935.818.1425.7917.980.07040.08065000
F-79het0.05160.451725.7629.217.7925.417.440.0640.07515000
F-88het0.0510.489421.2920.2416.4929.6816.470.06570.07060000
F-102hom0.05150.495119.9519.9315.4831.9916.610.0640.07494999
F-117hom0.05490.547827.3627.7519.2228.517.370.07110.08510000
F-70hom0.05130.535323.819.7818.5628.8515.880.06570.07600001
F-77hom0.05440.619919.4413.6316.1738.3416.120.07850.07720000




  DEXA Analysis data        Export Data to Spreadsheet
Mouse
Label 		Genotype Age (days) Site BMD BMC Length Weight FAT TTM
M-69 het 97 T-Animal Total 0.0544 0.5887 9.4 27.85 16.28 26.12
M-69 het 97 R-FR 0.0812 0.0347 9.4 27.85 15.35 0.57
M-69 het 97 R-FL 0.087 0.0353 9.4 27.85 21.11 0.59
M-69 het 97 R-V 0.0777 0.0326 9.4 27.85 9.77 0.77
F-79 het 95 R-V 0.064 0.0257 9.3 27.35 15.14 0.71
F-79 het 95 T-Animal Total 0.0516 0.4517 9.3 27.35 29.2 25.76
F-79 het 95 R-FR 0.0705 0.0262 9.3 27.35 22.62 0.56
F-79 het 95 R-FL 0.0798 0.0267 9.3 27.35 29.7 0.56
M-85 het 95 T-Animal Total 0.051 0.484 10.0 34.38 24.93 33.11
M-85 het 95 R-V 0.0659 0.0267 10.0 34.38 13.83 0.84
M-85 het 95 R-FL 0.076 0.0295 10.0 34.38 27.15 0.76
M-85 het 95 R-FR 0.0735 0.0282 10.0 34.38 18.3 0.58
F-88 het 95 T-Animal Total 0.051 0.4894 8.8 23.02 20.24 21.29
F-88 het 95 R-V 0.0657 0.0269 8.8 23.02 9.53 0.72
F-88 het 95 R-FR 0.0673 0.0274 8.8 23.02 18.84 0.52
F-88 het 95 R-FL 0.0739 0.0282 8.8 23.02 22.75 0.52
M-59 hom 97 T-Animal Total 0.0573 0.6463 9.6 35.02 19.08 33.42
M-59 hom 97 R-V 0.0768 0.0321 9.6 35.02 7.71 0.82
M-59 hom 97 R-FL 0.1004 0.0434 9.6 35.02 20.91 0.72
M-59 hom 97 R-FR 0.0921 0.0409 9.6 35.02 15.03 0.73
F-70 hom 97 T-Animal Total 0.0513 0.5353 9.6 25.68 19.78 23.8
F-70 hom 97 R-V 0.0657 0.0279 9.6 25.68 7.43 0.64
F-70 hom 97 R-FL 0.0793 0.029 9.6 25.68 21.2 0.54
F-70 hom 97 R-FR 0.0727 0.0287 9.6 25.68 14.2 0.43
F-77 hom 95 T-Animal Total 0.0544 0.6199 9.2 21.59 13.63 19.44
F-77 hom 95 R-V 0.0785 0.0335 9.2 21.59 6.92 0.67
F-77 hom 95 R-FL 0.0797 0.0306 9.2 21.59 11.34 0.47
F-77 hom 95 R-FR 0.0747 0.0322 9.2 21.59 6.2 0.44
M-82 hom 95 T-Animal Total 0.0533 0.5731 9.8 30.92 21.47 28.94
M-82 hom 95 R-FR 0.0781 0.0327 9.8 30.92 17.14 0.66
M-82 hom 95 R-V 0.0612 0.0245 9.8 30.92 9.47 0.77
M-82 hom 95 R-FL 0.0852 0.0335 9.8 30.92 22.55 0.71
F-102 hom 95 T-Animal Total 0.0515 0.4951 9.0 21.44 19.93 19.95
F-102 hom 95 R-FR 0.0722 0.0274 9.0 21.44 16.81 0.43
F-102 hom 95 R-V 0.064 0.0272 9.0 21.44 7.48 0.77
F-102 hom 95 R-FL 0.0777 0.0287 9.0 21.44 26.25 0.54
M-106 hom 94 T-Animal Total 0.0525 0.577 9.5 29.17 13.26 27.11
M-106 hom 94 R-V 0.0731 0.0304 9.5 29.17 7.93 0.76
M-106 hom 94 R-FR 0.0796 0.0338 9.5 29.17 9.35 0.56
M-106 hom 94 R-FL 0.0887 0.0354 9.5 29.17 11.63 0.65
M-110 hom 94 T-Animal Total 0.0507 0.5557 9.8 29.95 13.17 27.94
M-110 hom 94 R-V 0.0767 0.0325 9.8 29.95 6.98 0.76
M-110 hom 94 R-FR 0.0805 0.0335 9.8 29.95 6.81 0.61
M-110 hom 94 R-FL 0.0892 0.0326 9.8 29.95 13.69 0.65
F-117 hom 94 T-Animal Total 0.0549 0.5478 9.7 29.26 27.75 27.36
F-117 hom 94 R-V 0.0711 0.0311 9.7 29.26 14.27 0.78
F-117 hom 94 R-FR 0.0822 0.0325 9.7 29.26 23.06 0.53
F-117 hom 94 R-FL 0.088 0.0342 9.7 29.26 26.09 0.61
M-63 wt 97 T-Animal Total 0.0559 0.5988 9.9 36.18 22.43 34.57
M-63 wt 97 R-V 0.0682 0.0281 9.9 36.18 15.19 0.89
M-63 wt 97 R-FR 0.0814 0.0337 9.9 36.18 16.97 0.7
M-63 wt 97 R-FL 0.0905 0.035 9.9 36.18 20.83 0.71
M-89 wt 95 T-Animal Total 0.0586 0.6518 9.4 29.17 16.14 27.44
M-89 wt 95 R-V 0.0829 0.0345 9.4 29.17 9.06 0.8
M-89 wt 95 R-FR 0.0913 0.0423 9.4 29.17 11.54 0.54
M-89 wt 95 R-FL 0.099 0.0432 9.4 29.17 15.34 0.69
F-101 wt 95 T-Animal Total 0.0521 0.5273 9.0 23.38 19.28 21.53
F-101 wt 95 R-V 0.066 0.0283 9.0 23.38 6.13 0.76
F-101 wt 95 R-FR 0.0715 0.0305 9.0 23.38 14.02 0.48
F-101 wt 95 R-FL 0.0772 0.0283 9.0 23.38 19.17 0.49
F-121 wt 94 T-Animal Total 0.0533 0.468 9.4 30.12 35.8 28.99
F-121 wt 94 R-V 0.0704 0.0242 9.4 30.12 22.85 0.75
F-121 wt 94 R-FL 0.0825 0.0286 9.4 30.12 35.73 0.58
F-121 wt 94 R-FR 0.0788 0.0297 9.4 30.12 31.44 0.58
 


Copyright 2005 by Lexicon Genetics Incorporated
Lexicon Phenotypic Analysis software version 05.05.00.05