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Test Description: Groups of naïve mice are trained in conditioning chambers (Med-Associates, St. Albans, Vermont) that have stainless steel rod floors through which foot shocks are delivered. For cued trace fear conditioning mice are placed in training context and left undisturbed for habituation purposes for 3 min. Then a conditioned stimulus (CS: 15 sec duration, 85 dB 3kHz) generated by tone is delivered, followed by a trace period of 10 sec and the unconditioned stimulus (US: foot shock, 2 sec, 0.35 mA). Mice are presented with 3 trials with inter-trial interval (ITI) 2 min and returned to the home cage 1 minute after the final shock.


Results








  Trace Aversive Conditioning data        Export Data to Spreadsheet
Mouse Label Genotype Age (days) Pre-CS Freezing Post-CS Freezing Difference CS Freezing
M-72 hom 85 0.0 8.89 8.89
M-80 hom 85 1.11 33.33 32.22
M-83 hom 85 0.0 2.22 2.22
F-95 hom 84 0.0 0.0 0.0
F-97 hom 84 0.0 6.67 6.67
F-102 hom 84 56.67 97.78 41.11
M-106 hom 84 1.11 4.44 3.33
F-120 hom 84 2.22 45.56 43.34
M-74 wt 85 1.11 0.0 -1.11
M-76 wt 85 0.0 3.33 3.33
M-79 wt 85 44.44 57.78 13.34
F-93 wt 84 3.33 13.33 10.0
F-103 wt 84 0.0 51.11 51.11
F-104 wt 84 0.0 3.33 3.33
F-121 wt 84 0.0 53.33 53.33
M-141 wt 84 0.0 2.22 2.22
 


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Lexicon Phenotypic Analysis software version 05.05.00.05