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Test Description: Bacterial lipopolysaccharide (LPS) is an endotoxin, a potent inducer of the acute phase response and systemic inflammation. The mice will:
  • Be injected intraperitoneally (i.p.) with a sublethal dose of LPS in 200 µL sterile saline using a 26 gauge needle.
  • The dose will be based on the average weight of the mice tested at 1 g/g body weight 3 hours after injection, a 100ul blood sample will be taken and analyzed for the presence of TNFα, MCP-1, and IL-6 on the FACSCalibur.


Results





  Acute Phase Response data for Project: NIH-1289 - Results        Export Data to Spreadsheet
Mouse Label Genotype Age (days) TNF-a MCP-1 IL-6
M-72 hom 113 1152.5 38583.1 16015.1
M-80 hom 113 1473.0 47973.7 25706.4
M-83 hom 113 423.4 28274.5 8315.3
M-106 hom 112 842.8 31616.1 12874.7
M-74 wt 113 865.7 42348.2 20718.4
M-76 wt 113 308.9 11858.9 1150.5
M-79 wt 113 370.1 29072.0 7718.7
M-141 wt 112 2297.7 54870.7 25023.6
 


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Lexicon Phenotypic Analysis software version 05.05.00.05