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DEXA for Project: NIH-1289
Test Description: Mice were anesthetized by intraperitoneal injection of Avertin (1.25% 2,2,2,-tribromoethanol, 20 ml/kg body weight ), measured body length and weight, and then placed in a prone position on the platform of the PIXImusTM Densitometer (Lunar Inc.) for a DEXA scan. Using a Lunar PIXImus software, the Bone mineral density (BMD) and fat composition (% fat) and total tissue mass (TTM) were determined in the regions of interest (ROI, i.e., whole body, vertebrae, and both femurs).


Results

  BMD = Bone Mineral Density (g/cm2);
  BMC = Bone Mineral Content (g);
  LBM = Lean Body Mass (g);
  BMC / LBM = BMC / LBM (mg/g); 		  FAT(%) = % of Body FAT;
  FAT(g) = TTM X FAT(%)/100;
  TTM = Total Tissue Mass (g);
  vBMD = Volumetric BMD (mg/cm3)

MALE DATA




FEMALE DATA



DEXA Combined Gender Score
Parameter Score
Body BMD  94.7%
Body vBMD  97.6%
Body BMC/LBM  97.7%
Femur BMD  96.2%
Vertebral BMD  97.6%
Total Tissue Mass  92.0%
Body LBM  91.4%
Body % Fat  106.1%
Body Fat Content  97.7%
The Combined Gender Score provides the average ration of Hom to WT values combining
males and females, with a correction factor for the number of mice in each group. No score
is generated if there are fewer than 4 HOM mice or fewer than 3 WT mice


DEXA Analysis: Male
Mouse Label Genotype Whole Body Vertebrae Femurs
BMD (g/cm2) BMC (g) TTM % FAT LBM (g) BMC / LBM (mg/g) vBMD (mg/cm3) BMD (g/cm2) BMD (g/cm2)
M-74wt0.06010.619832.4521.5324.8424.9518.720.07330.08715000
M-76wt0.06270.638141.8529.7728.7522.1919.650.08530.09435000
M-73het0.05520.530439.8624.4729.5817.9317.810.0590.08310001
M-81het0.0520.454529.4224.9721.6221.0217.60.05550.07665000
M-106hom0.05150.475730.2919.923.7920.016.940.05280.08075000
M-72hom0.05760.599333.2220.7625.7223.317.860.06670.08535000
M-80hom0.05910.56637.6129.925.821.9419.10.06610.08750000
M-83hom0.06130.605337.4327.7826.4322.919.510.07460.09370000

DEXA Analysis: Female
Mouse Label Genotype Whole Body Vertebrae Femurs
BMD (g/cm2) BMC (g) TTM % FAT LBM (g) BMC / LBM (mg/g) vBMD (mg/cm3) BMD (g/cm2) BMD (g/cm2)
F-103wt0.05210.504424.8517.5819.9825.2516.750.06540.07340001
F-93wt0.05020.482723.5113.5119.8524.3216.190.05550.07155000
F-137het0.05150.497420.8713.9317.4728.4816.570.06750.07535000
F-94het0.05120.42527.0328.0119.0322.3317.770.05850.07655000
F-102hom0.04930.450125.6223.0719.2623.3716.320.05840.06919999
F-120hom0.04920.406119.5816.8315.8825.5817.130.06140.07280000
F-95hom0.05010.496122.0714.0218.4826.8515.920.06270.07150000
F-97hom0.04780.413420.6118.416.425.216.260.06170.06715000




  DEXA Analysis data        Export Data to Spreadsheet
Mouse
Label 		Genotype Age (days) Site BMD BMC Length Weight FAT TTM
M-73 het 102 T-Animal Total 0.0552 0.5304 9.7 40.42 24.47 39.86
M-73 het 102 R-V 0.059 0.0313 9.7 40.42 13.43 1.63
M-73 het 102 R-FL 0.0881 0.038 9.7 40.42 29.28 0.92
M-73 het 102 R-FR 0.0781 0.0346 9.7 40.42 34.68 0.98
M-81 het 102 T-Animal Total 0.052 0.4545 9.0 29.98 24.97 29.42
M-81 het 102 R-V 0.0555 0.0224 9.0 29.98 15.47 1.27
M-81 het 102 R-FL 0.0797 0.0297 9.0 29.98 32.19 0.77
M-81 het 102 R-FR 0.0736 0.0281 9.0 29.98 20.97 0.68
F-94 het 101 T-Animal Total 0.0512 0.425 9.4 27.86 28.01 27.03
F-94 het 101 R-FL 0.0813 0.0294 9.4 27.86 26.95 0.61
F-94 het 101 R-FR 0.0718 0.0281 9.4 27.86 24.22 0.61
F-94 het 101 R-V 0.0585 0.0156 9.4 27.86 22.24 0.81
F-137 het 101 T-Animal Total 0.0515 0.4974 9.2 22.04 13.93 20.87
F-137 het 101 R-V 0.0675 0.0232 9.2 22.04 5.71 0.91
F-137 het 101 R-FR 0.075 0.0329 9.2 22.04 14.12 0.61
F-137 het 101 R-FL 0.0757 0.0292 9.2 22.04 16.58 0.59
M-72 hom 102 T-Animal Total 0.0576 0.5993 9.7 33.93 20.76 33.22
M-72 hom 102 R-V 0.0667 0.025 9.7 33.93 10.97 1.15
M-72 hom 102 R-FL 0.0866 0.0429 9.7 33.93 25.7 0.95
M-72 hom 102 R-FR 0.0841 0.0425 9.7 33.93 18.56 0.81
M-80 hom 102 T-Animal Total 0.0591 0.566 9.5 38.14 29.9 37.61
M-80 hom 102 R-V 0.0661 0.0235 9.5 38.14 19.84 1.25
M-80 hom 102 R-FL 0.0915 0.0383 9.5 38.14 36.02 0.8
M-80 hom 102 R-FR 0.0835 0.0415 9.5 38.14 32.63 0.98
M-83 hom 102 T-Animal Total 0.0613 0.6053 9.9 37.93 27.78 37.43
M-83 hom 102 R-V 0.0746 0.0281 9.9 37.93 14.81 1.21
M-83 hom 102 R-FL 0.0978 0.041 9.9 37.93 32.02 0.85
M-83 hom 102 R-FR 0.0896 0.0418 9.9 37.93 27.01 0.84
F-95 hom 101 T-Animal Total 0.0501 0.4961 9.1 23.55 14.02 22.07
F-95 hom 101 R-FR 0.0708 0.0299 9.1 23.55 13.96 0.53
F-95 hom 101 R-V 0.0627 0.02 9.1 23.55 4.88 0.93
F-95 hom 101 R-FL 0.0722 0.0293 9.1 23.55 17.69 0.65
F-97 hom 101 T-Animal Total 0.0478 0.4134 8.8 21.72 18.4 20.61
F-97 hom 101 R-FL 0.0696 0.028 8.8 21.72 23.28 0.66
F-97 hom 101 R-FR 0.0647 0.0261 8.8 21.72 19.43 0.6
F-97 hom 101 R-V 0.0617 0.02 8.8 21.72 8.41 0.78
F-102 hom 101 T-Animal Total 0.0493 0.4501 9.2 26.45 23.07 25.62
F-102 hom 101 R-V 0.0584 0.0197 9.2 26.45 11.33 1.01
F-102 hom 101 R-FR 0.0668 0.0282 9.2 26.45 23.47 0.67
F-102 hom 101 R-FL 0.0716 0.0268 9.2 26.45 29.04 0.66
M-106 hom 101 T-Animal Total 0.0515 0.4757 9.1 30.93 19.9 30.29
M-106 hom 101 R-V 0.0528 0.0159 9.1 30.93 10.42 1.05
M-106 hom 101 R-FL 0.0824 0.0329 9.1 30.93 23.47 0.74
M-106 hom 101 R-FR 0.0791 0.0357 9.1 30.93 14.96 0.8
F-120 hom 101 T-Animal Total 0.0492 0.4061 8.7 20.69 16.83 19.58
F-120 hom 101 R-V 0.0614 0.0205 8.7 20.69 8.14 0.81
F-120 hom 101 R-FR 0.0732 0.0283 8.7 20.69 16.82 0.52
F-120 hom 101 R-FL 0.0724 0.0285 8.7 20.69 21.09 0.63
M-74 wt 102 T-Animal Total 0.0601 0.6198 9.4 33.22 21.53 32.45
M-74 wt 102 R-FR 0.082 0.0353 9.4 33.22 20.25 0.77
M-74 wt 102 R-FL 0.0923 0.0344 9.4 33.22 28.08 0.71
M-74 wt 102 R-V 0.0733 0.029 9.4 33.22 12.1 1.2
M-76 wt 102 T-Animal Total 0.0627 0.6381 9.5 42.43 29.77 41.85
M-76 wt 102 R-V 0.0853 0.0257 9.5 42.43 21.68 1.17
M-76 wt 102 R-FR 0.089 0.046 9.5 42.43 27.21 0.99
M-76 wt 102 R-FL 0.0997 0.0468 9.5 42.43 34.22 1.1
F-93 wt 101 T-Animal Total 0.0502 0.4827 9.0 24.73 13.51 23.51
F-93 wt 101 R-V 0.0555 0.027 9.0 24.73 4.52 1.26
F-93 wt 101 R-FL 0.0731 0.0305 9.0 24.73 17.08 0.65
F-93 wt 101 R-FR 0.07 0.03 9.0 24.73 13.7 0.59
F-103 wt 101 T-Animal Total 0.0521 0.5044 9.2 26.0 17.58 24.85
F-103 wt 101 R-V 0.0654 0.0235 9.2 26.0 7.85 1.14
F-103 wt 101 R-FL 0.0754 0.0303 9.2 26.0 21.46 0.7
F-103 wt 101 R-FR 0.0714 0.0294 9.2 26.0 21.02 0.68
 


Copyright 2005 by Lexicon Genetics Incorporated
Lexicon Phenotypic Analysis software version 05.05.00.05