Inverted Screen for Project: NIH-0769 Test Description: A motor strength deficit is apparent when there is a 50% point difference between (-/-) or (+/-) mice and (+/+) mice for the fell down response. 0/8 or 1/8 (-/-) or (+/-) mice not climbing indicates impaired motor coordination. 7/8 or 8/8(-/-) or (+/-) mice climbing up indicates enhanced motor coordination.

Results Genotype Ratio Fell Down % Ratio Climbed Up % +/+ (n=8) 0/8 0 4/8 50 -/- (n=8) 0/8 0 5/8 63 WT Population Fell Down 3.62 Climbed Up 60.04 *Red color coding indicates a notable difference.

Inverted Screen data for Project: NIH-0769 - Results        Mouse Label Genotype Age (days) Test Result Weight at Testing Comments F-276 hom 79 Climbed Up 20.8 25 seconds M-279 hom 79 Did Not Climb 31.4 M-293 hom 79 Did Not Climb 31.1 M-304 hom 79 Climbed Up 33.2 56seconds M-310 hom 78 Climbed Up 32.0 23 seconds F-323 hom 78 Climbed Up 22.7 20 seconds F-348 hom 77 Did Not Climb 21.7 F-365 hom 77 Climbed Up 21.2 5 seconds F-264 wt 80 Climbed Up 27.5 9 seconds F-299 wt 79 Climbed Up 25.7 12 seconds M-320 wt 78 Did Not Climb 31.7 M-325 wt 77 Did Not Climb 33.2 F-340 wt 77 Climbed Up 23.8 7 seconds M-341 wt 77 Did Not Climb 28.2 F-353 wt 77 Climbed Up 28.3 8 seconds M-358 wt 77 Did Not Climb 31.1

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Lexicon Phenotypic Analysis software version 05.05.00.05