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DEXA for Project: NIH-0769
Test Description: Mice were anesthetized by intraperitoneal injection of Avertin (1.25% 2,2,2,-tribromoethanol, 20 ml/kg body weight ), measured body length and weight, and then placed in a prone position on the platform of the PIXImusTM Densitometer (Lunar Inc.) for a DEXA scan. Using a Lunar PIXImus software, the Bone mineral density (BMD) and fat composition (% fat) and total tissue mass (TTM) were determined in the regions of interest (ROI, i.e., whole body, vertebrae, and both femurs).


Results

  BMD = Bone Mineral Density (g/cm2);
  BMC = Bone Mineral Content (g);
  LBM = Lean Body Mass (g);
  BMC / LBM = BMC / LBM (mg/g); 		  FAT(%) = % of Body FAT;
  FAT(g) = TTM X FAT(%)/100;
  TTM = Total Tissue Mass (g);
  vBMD = Volumetric BMD (mg/cm3)

MALE DATA




FEMALE DATA



DEXA Combined Gender Score
Parameter Score
Body BMD  99.9%
Body vBMD  96.4%
Body BMC/LBM  104.1%
Femur BMD  98.4%
Vertebral BMD  96.4%
Total Tissue Mass  95.8%
Body LBM  103.9%
Body % Fat  74.3%
Body Fat Content  70.6%
The Combined Gender Score provides the average ration of Hom to WT values combining
males and females, with a correction factor for the number of mice in each group. No score
is generated if there are fewer than 4 HOM mice or fewer than 3 WT mice


DEXA Analysis: Male
Mouse Label Genotype Whole Body Vertebrae Femurs
BMD (g/cm2) BMC (g) TTM % FAT LBM (g) BMC / LBM (mg/g) vBMD (mg/cm3) BMD (g/cm2) BMD (g/cm2)
M-320wt0.0550.514231.3222.5923.7321.6717.980.05510.08445000
M-341wt0.05550.567928.5620.5622.1225.6717.360.06490.09170000
M-266het0.05070.506731.0319.9324.3420.8216.040.05910.07355000
M-271het0.04960.453334.4629.0923.9818.916.410.04920.07375000
M-279hom0.0570.647429.6614.1524.8226.0916.910.06970.09645000
M-293hom0.05890.645532.415.2326.8224.0717.790.06290.09570000
M-304hom0.05770.613334.0412.6829.1121.0717.710.06340.09485000
M-310hom0.05020.479431.4720.6724.4919.5816.240.04710.08045000

DEXA Analysis: Female
Mouse Label Genotype Whole Body Vertebrae Femurs
BMD (g/cm2) BMC (g) TTM % FAT LBM (g) BMC / LBM (mg/g) vBMD (mg/cm3) BMD (g/cm2) BMD (g/cm2)
F-264wt0.04980.418128.0431.1118.922.1217.190.05220.07380000
F-340wt0.04970.42223.9525.3917.4524.1917.050.06320.07555000
F-290het0.05130.495923.9823.6217.8227.8316.50.05610.07860000
F-333het0.05090.459922.1216.8117.9425.6316.930.05420.07305001
F-276hom0.04590.41921.7920.2416.9624.715.190.05080.06555000
F-323hom0.04880.421522.1520.4917.1924.5216.610.05410.07115000
F-348hom0.05240.504421.9820.3916.9929.6816.890.06590.07270000
F-365hom0.04890.414922.5324.7116.5525.0716.790.06080.06705000




  DEXA Analysis data        Export Data to Spreadsheet
Mouse
Label 		Genotype Age (days) Site BMD BMC Length Weight FAT TTM
M-266 het 107 T-Animal Total 0.0507 0.5067 10.1 32.17 19.93 31.03
M-266 het 107 R-V 0.0591 0.0243 10.1 32.17 11.71 1.33
M-266 het 107 R-FL 0.0739 0.0307 10.1 32.17 26.11 0.88
M-266 het 107 R-FR 0.0732 0.0304 10.1 32.17 17.7 0.79
M-271 het 107 T-Animal Total 0.0496 0.4533 10.1 34.98 29.09 34.46
M-271 het 107 R-V 0.0492 0.0178 10.1 34.98 20.14 1.37
M-271 het 107 R-FL 0.0726 0.0347 10.1 34.98 22.26 0.88
M-271 het 107 R-FR 0.0749 0.0308 10.1 34.98 28.86 0.84
F-290 het 107 T-Animal Total 0.0513 0.4959 9.5 25.04 23.62 23.98
F-290 het 107 R-FR 0.0763 0.0301 9.5 25.04 25.39 0.66
F-290 het 107 R-V 0.0561 0.0228 9.5 25.04 10.42 1.18
F-290 het 107 R-FL 0.0809 0.0323 9.5 25.04 28.15 0.73
F-333 het 105 T-Animal Total 0.0509 0.4599 9.5 23.46 16.81 22.12
F-333 het 105 R-FL 0.0746 0.0284 9.5 23.46 22.6 0.74
F-333 het 105 R-V 0.0542 0.0205 9.5 23.46 7.24 1.2
F-333 het 105 R-FR 0.0715 0.0285 9.5 23.46 17.51 0.64
F-276 hom 107 T-Animal Total 0.0459 0.419 9.3 22.65 20.24 21.79
F-276 hom 107 R-V 0.0508 0.0204 9.3 22.65 9.09 1.06
F-276 hom 107 R-FL 0.0664 0.0246 9.3 22.65 22.87 0.62
F-276 hom 107 R-FR 0.0647 0.0262 9.3 22.65 19.6 0.62
M-279 hom 107 T-Animal Total 0.057 0.6474 10.1 31.17 14.15 29.66
M-279 hom 107 R-V 0.0697 0.0259 10.1 31.17 11.97 1.23
M-279 hom 107 R-FL 0.0992 0.0441 10.1 31.17 17.49 0.8
M-279 hom 107 R-FR 0.0937 0.0462 10.1 31.17 8.08 0.83
M-293 hom 107 T-Animal Total 0.0589 0.6455 10.1 33.23 15.23 32.4
M-293 hom 107 R-V 0.0629 0.0265 10.1 33.23 8.27 1.42
M-293 hom 107 R-FL 0.0993 0.0471 10.1 33.23 18.9 0.89
M-293 hom 107 R-FR 0.0921 0.0453 10.1 33.23 11.86 0.85
M-304 hom 107 T-Animal Total 0.0577 0.6133 10.7 35.3 12.68 34.04
M-304 hom 107 R-V 0.0634 0.0283 10.7 35.3 6.57 1.47
M-304 hom 107 R-FL 0.0967 0.0453 10.7 35.3 16.41 0.93
M-304 hom 107 R-FR 0.093 0.0495 10.7 35.3 9.48 0.95
M-310 hom 106 T-Animal Total 0.0502 0.4794 10.3 32.55 20.67 31.47
M-310 hom 106 R-V 0.0471 0.0196 10.3 32.55 10.69 1.5
M-310 hom 106 R-FL 0.0824 0.0362 10.3 32.55 25.01 0.93
M-310 hom 106 R-FR 0.0785 0.0341 10.3 32.55 20.6 0.84
F-323 hom 106 T-Animal Total 0.0488 0.4215 9.4 23.31 20.49 22.15
F-323 hom 106 R-V 0.0541 0.0195 9.4 23.31 9.87 0.95
F-323 hom 106 R-FR 0.0686 0.0284 9.4 23.31 21.89 0.66
F-323 hom 106 R-FL 0.0737 0.0259 9.4 23.31 25.09 0.63
F-348 hom 105 R-FR 0.0717 0.0319 9.5 22.98 20.05 0.71
F-348 hom 105 T-Animal Total 0.0524 0.5044 9.5 22.98 20.39 21.98
F-348 hom 105 R-FL 0.0737 0.0289 9.5 22.98 26.04 0.67
F-348 hom 105 R-V 0.0659 0.0259 9.5 22.98 12.93 1.17
F-365 hom 105 T-Animal Total 0.0489 0.4149 9.4 23.32 24.71 22.53
F-365 hom 105 R-V 0.0608 0.0227 9.4 23.32 15.78 1.15
F-365 hom 105 R-FR 0.0646 0.0238 9.4 23.32 30.64 0.63
F-365 hom 105 R-FL 0.0695 0.0245 9.4 23.32 33.2 0.67
F-264 wt 108 T-Animal Total 0.0498 0.4181 9.9 28.82 31.11 28.04
F-264 wt 108 R-V 0.0522 0.0178 9.9 28.82 17.48 1.07
F-264 wt 108 R-FL 0.0744 0.0299 9.9 28.82 37.27 0.91
F-264 wt 108 R-FR 0.0732 0.0315 9.9 28.82 32.79 0.85
M-320 wt 106 T-Animal Total 0.055 0.5142 10.2 32.11 22.59 31.32
M-320 wt 106 R-V 0.0551 0.0198 10.2 32.11 12.59 1.2
M-320 wt 106 R-FR 0.0859 0.0392 10.2 32.11 22.25 0.87
M-320 wt 106 R-FL 0.083 0.0372 10.2 32.11 28.03 1.0
F-340 wt 105 T-Animal Total 0.0497 0.422 9.3 24.83 25.39 23.95
F-340 wt 105 R-V 0.0632 0.024 9.3 24.83 11.72 1.18
F-340 wt 105 R-FL 0.0797 0.0301 9.3 24.83 32.04 0.75
F-340 wt 105 R-FR 0.0714 0.028 9.3 24.83 26.69 0.68
M-341 wt 105 T-Animal Total 0.0555 0.5679 10.0 29.66 20.56 28.56
M-341 wt 105 R-V 0.0649 0.0249 10.0 29.66 12.35 1.34
M-341 wt 105 R-FR 0.0875 0.037 10.0 29.66 15.65 0.64
M-341 wt 105 R-FL 0.0959 0.0379 10.0 29.66 25.5 0.71
 


Copyright 2005 by Lexicon Genetics Incorporated
Lexicon Phenotypic Analysis software version 05.05.00.05